KEGG   PATHWAY: reu00260
Entry
reu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Cupriavidus pinatubonensis JMP134
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
reu00260  Glycine, serine and threonine metabolism
reu00260

Module
reu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:reu00260]
reu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:reu00260]
reu_M00555  Betaine biosynthesis, choline => betaine [PATH:reu00260]
reu_M00621  Glycine cleavage system [PATH:reu00260]
reu_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:reu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cupriavidus pinatubonensis JMP134 [GN:reu]
Gene
Reut_A1126  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Reut_A2310  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Reut_A1993  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Reut_A0870  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Reut_A1992  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
Reut_A0859  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Reut_A0790  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Reut_B4822  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Reut_B5140  Aminotransferase, class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Reut_A0152  6-phosphogluconate dehydrogenase, NAD-binding protein:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Reut_A0892  6-phosphogluconate dehydrogenase, NAD-binding protein:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Reut_A2281  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Reut_A3294  glycerate 2-kinase [KO:K11529] [EC:2.7.1.165]
Reut_A0463  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Reut_A0304  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Reut_A0479  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Reut_A3421  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Reut_B4615  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Reut_C5898  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Reut_B4747  Amino acid-binding protein ACT:6-phosphogluconate dehydrogenase, NAD-binding protein:D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Reut_A2576  phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]
Reut_A1357  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Reut_B4803  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Reut_C6401  Twin-arginine translocation pathway signal [KO:K00274] [EC:1.4.3.4]
Reut_A3331  glycine dehydrogenase (decarboxylating) alpha subunit / glycine dehydrogenase (decarboxylating) beta subunit [KO:K00281] [EC:1.4.4.2]
Reut_B4806  Glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Reut_A3329  Glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Reut_A2045  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Reut_A1306  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Reut_B4451  FAD-dependent pyridine nucleotide-disulfide oxidoreductase:Pyridine nucleotide-disulfide oxidoreductase dimerization region [KO:K00382] [EC:1.8.1.4]
Reut_A3330  Glycine cleavage H-protein [KO:K02437]
Reut_B4325  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Reut_A0951  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Reut_B5834  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Reut_B5835  aldehyde dehydrogenase (acceptor) [KO:K00130] [EC:1.2.1.8]
Reut_B4815  Rieske (2Fe-2S) region [KO:K00479] [EC:1.14.13.251]
Reut_B4814  Ferredoxin:Oxidoreductase FAD/NAD(P)-binding:Oxidoreductase FAD-binding region [KO:K21832] [EC:1.14.13.251]
Reut_B4819  NADH:flavin oxidoreductase/NADH oxidase:HI0933-like protein [KO:K21833] [EC:1.5.7.3]
Reut_B4818  4Fe-4S ferredoxin, iron-sulfur binding:Protein of unknown function DUF224, cysteine-rich region [KO:K21834]
Reut_B4817  Electron transfer flavoprotein beta-subunit:Electron transfer flavoprotein, alpha subunit [KO:K25960]
Reut_B4816  Electron transfer flavoprotein beta-subunit [KO:K25961]
Reut_B4828  Sarcosine oxidase, alpha subunit, heterotetrameric [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Reut_B4830  Sarcosine oxidase, beta subunit, heterotetrameric [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Reut_B4827  Sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Reut_B4829  Sarcosine oxidase, delta subunit, heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Reut_B3684  Pyridoxal-5'-phosphate-dependent enzyme, beta subunit [KO:K01697] [EC:4.2.1.22]
Reut_B4807  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Reut_A3333  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Reut_B4831  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Reut_A0413  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Reut_B4909  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Reut_C6117  Pyridoxal-5'-phosphate-dependent enzyme, beta subunit [KO:K17989] [EC:4.3.1.17 4.3.1.19]
Reut_B4022  dsd; probable D-serine deaminase (d-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
Reut_A2915  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
Reut_A2304  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
Reut_A2306  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
reu00010  Glycolysis / Gluconeogenesis
reu00020  Citrate cycle (TCA cycle)
reu00230  Purine metabolism
reu00250  Alanine, aspartate and glutamate metabolism
reu00270  Cysteine and methionine metabolism
reu00290  Valine, leucine and isoleucine biosynthesis
reu00300  Lysine biosynthesis
reu00330  Arginine and proline metabolism
reu00460  Cyanoamino acid metabolism
reu00470  D-Amino acid metabolism
reu00564  Glycerophospholipid metabolism
reu00620  Pyruvate metabolism
reu00630  Glyoxylate and dicarboxylate metabolism
reu00640  Propanoate metabolism
reu00680  Methane metabolism
reu00860  Porphyrin metabolism
reu00920  Sulfur metabolism
KO pathway
ko00260   
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