KEGG   PATHWAY: rhid00260
Entry
rhid00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium hidalgonense
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rhid00260  Glycine, serine and threonine metabolism
rhid00260

Module
rhid_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rhid00260]
rhid_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rhid00260]
rhid_M00555  Betaine biosynthesis, choline => betaine [PATH:rhid00260]
rhid_M00621  Glycine cleavage system [PATH:rhid00260]
rhid_M00919  Ectoine degradation, ectoine => aspartate [PATH:rhid00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium hidalgonense [GN:rhid]
Gene
FFM81_002125  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FFM81_000075  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FFM81_011640  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FFM81_025755  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FFM81_031335  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FFM81_016210  homoserine kinase [KO:K02204] [EC:2.7.1.39]
FFM81_025775  homoserine kinase [KO:K02204] [EC:2.7.1.39]
FFM81_016100  threonine synthase [KO:K01733] [EC:4.2.3.1]
FFM81_003155  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
FFM81_025695  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
FFM81_013550  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FFM81_022595  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FFM81_020190  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FFM81_025805  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FFM81_012075  glycerate kinase [KO:K11529] [EC:2.7.1.165]
FFM81_020240  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
FFM81_009550  phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
FFM81_003705  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FFM81_024400  dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FFM81_003700  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
FFM81_007190  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
FFM81_006350  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
FFM81_006355  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
FFM81_001585  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
FFM81_029835  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
FFM81_010135  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
FFM81_010145  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
FFM81_027460  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
FFM81_029880  DUF1989 domain-containing protein [KO:K00605] [EC:2.1.2.10]
FFM81_029940  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
FFM81_022650  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FFM81_001340  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FFM81_011325  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FFM81_010140  gcvH; glycine cleavage system protein GcvH [KO:K02437]
FFM81_014020  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
FFM81_015315  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
FFM81_015310  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
FFM81_024895  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
FFM81_025950  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
FFM81_027360  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
FFM81_024490  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
FFM81_016485  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
FFM81_024495  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
FFM81_002970  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
FFM81_002960  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
FFM81_002975  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
FFM81_002965  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
FFM81_010285  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
FFM81_003310  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
FFM81_012275  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
FFM81_023140  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
FFM81_025645  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
FFM81_025710  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
FFM81_000120  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
FFM81_022215  alanine racemase [KO:K01753] [EC:4.3.1.18]
FFM81_021020  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
FFM81_021025  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
FFM81_016385  ectoine synthase [KO:K06720] [EC:4.2.1.108]
FFM81_023130  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
FFM81_023125  doeB; N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
FFM81_023185  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
FFM81_025745  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
FFM81_023180  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rhid00010  Glycolysis / Gluconeogenesis
rhid00020  Citrate cycle (TCA cycle)
rhid00230  Purine metabolism
rhid00250  Alanine, aspartate and glutamate metabolism
rhid00270  Cysteine and methionine metabolism
rhid00290  Valine, leucine and isoleucine biosynthesis
rhid00300  Lysine biosynthesis
rhid00330  Arginine and proline metabolism
rhid00460  Cyanoamino acid metabolism
rhid00470  D-Amino acid metabolism
rhid00564  Glycerophospholipid metabolism
rhid00600  Sphingolipid metabolism
rhid00620  Pyruvate metabolism
rhid00630  Glyoxylate and dicarboxylate metabolism
rhid00640  Propanoate metabolism
rhid00680  Methane metabolism
rhid00860  Porphyrin metabolism
rhid00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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