KEGG   PATHWAY: rn00997
Entry
rn00997                     Pathway                                
Name
Biosynthesis of various other secondary metabolites
  Including
Ditryptophenaline biosynthesis, Fumiquinazoline D biosynthesis, Paerucumarin biosynthesis, Staphyloferrin B biosynthesis, Cyclooctatin biosynthesis, Lovastatin biosynthesis, Grixazone biosynthesis, Staphyloferrin A biosynthesis, Ethynylserine biosynthesis, Aerobactin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
rn00997  Biosynthesis of various other secondary metabolites
rn00997

Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B [PATH:rn00997]
M00876  Staphyloferrin A biosynthesis, L-ornithine => staphyloferrin A [PATH:rn00997]
M00891  Ditryptophenaline biosynthesis, tryptophan + phenylalanine => ditryptophenaline [PATH:rn00997]
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid [PATH:rn00997]
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline [PATH:rn00997]
M00905  Grixazone biosynthesis, aspartate 4-semialdehyde => grixazone B [PATH:rn00997]
M00906  Ethynylserine biosynthesis, lysine => ethynylserine [PATH:rn00997]
M00918  Aerobactin biosynthesis, lysine => aerobactin [PATH:rn00997]
M00921  Cyclooctatin biosynthesis, dimethylallyl-PP + isopentenyl-PP => cyclooctatin [PATH:rn00997]
Reaction
R00448  L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)
R00672  ornithine racemase
R01658  dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase
R02003  geranyl-diphosphate:isopentenyl-diphosphate geranyltrans-transferase
R02061  trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
R03168  acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase
R07251  acyl-CoA:malonyl-CoA C-acyltransferase (dihydromonacolin L-[acp]-forming)
R10090  citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (AMP-forming)
R10091  N2-citryl-N6-acetyl-N6-hydroxy-L-lysine:N6-acetyl-N6-hydroxy-L-lysine ligase (AMP-forming)
R10469  2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate hydro-lyase (cyclizing, 3-amino-4-hydroxybenzoate-forming)
R10673  2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate L-aspartate-4-semialdehyde-lyase (glycerone-phosphate-forming)
R10720  3-amino-4-hydroxybenzoate:N-acetyl-L-cysteine:oxygen oxidoreductase
R10763  geranylgeranyl-diphosphate diphosphate-lyase (cyclooctat-9-en-7-ol-forming)
R10791  dihydromonacolin L acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
R10792  3alpha-hydroxy-3,5-dihydromonacolin L acid hydro-lyase
R10794  monacolin L acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating)
R11126  monacolin-J-acid:(S)-2-methylbutanoyl-[acp] (S)-2-methylbutanoyltransferase
R11187  dihydromonacolin L-[acyl-carrier protein] hydrolase
R11445  malonyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, methylating, 2-methylbutanoate-forming)
R11655  N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate:NAD+ dehydrogenase (L-2,3-diaminopropanoate-forming)
R11705  O-phospho-L-serine:L-glutamate N-(2S)-2-amino-2-carboxyethyltransferase
R12081  (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase
R12150  L-tyrosine:D-ribulose-5-phosphate lyase (isonitrile-forming)
R12177  cyclooctat-9-en-7-ol,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)
R12178  cyclooctat-9-ene-5,7-diol,hydrogen-donor:oxygen oxidoreductase (18-hydroxylating)
R12308  L-2,3-diaminopropanoate:citrate ligase (AMP, 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
R12309  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
R12311  2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate:L-2,3-diaminopropanoate ligase {2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate-forming}
R12312  2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate:2-oxoglutarate ligase (staphyloferrin B-forming)
R12344  ATP:L-serine 3-phosphotransferase
R12353  D-ornithine:citrate ligase (AMP-forming)
R12354  N5-[(S)-citryl]-D-ornithine:citrate ligase (AMP, staphyloferrin A-forming)
R12407  L-lysine,2-oxoglutarate:oxygen oxidoreductase (4-halogenating)
R12408  4-chloro-L-lysine,hydrogen-donor:oxygen oxidoreductase
R12409  
R12410  
R12411  gamma-L-glutamyl-L-propargylglycine,2-oxoglutarate:oxygen oxidoreductase
R12412  
R12413  
R12414  S-adenosyl-L-methionine:cyclo(L-Trp-L-Phe) N-methyltransferase
R12415  
R12417  
R12418  
R12419  
R12420  
R12421  
R12884  
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00065  L-Serine
C00077  L-Ornithine
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00108  Anthranilate
C00129  Isopentenyl diphosphate
C00197  3-Phospho-D-glycerate
C00251  Chorismate
C00279  D-Erythrose 4-phosphate
C00353  Geranylgeranyl diphosphate
C00441  L-Aspartate 4-semialdehyde
C00515  D-Ornithine
C01005  O-Phospho-L-serine
C01028  N6-Hydroxy-L-lysine
C03401  L-2,3-Diaminopropanoate
C03955  N6-Acetyl-N6-hydroxy-L-lysine
C04075  2-Amino-4-chloro-4-pentenoic acid
C05554  Aerobactin
C12115  3-Amino-4-hydroxybenzoate
C20333  N2-Citryl-N6-acetyl-N6-hydroxy-L-lysine
C20644  2-Amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate
C20799  Grixazone B
C20834  Cyclooctat-9-en-7-ol
C20851  Dihydromonacolin L acid
C20852  3alpha-Hydroxy-3,5-dihydromonacolin L acid
C20853  Monacolin L acid
C20854  Monacolin J acid
C21108  Dihydromonacolin L-[acyl-carrier protein]
C21129  (S)-2-Methylbutanoyl-[acp]
C21130  Lovastatin acid
C21559  N-[(2S)-2-Amino-2-carboxyethyl]-L-glutamate
C21889  (2S)-3-(4-Hydroxyphenyl)-2-isocyanopropanoate
C21891  (2E)-3-(4-Hydroxyphenyl)-2-isocyanoprop-2-enoate
C21978  Cyclooctat-9-ene-5,7-diol
C21979  Cyclooctatin
C22072  2-[(L-Alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate
C22073  2-[(2-Aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate
C22074  2-[(L-Alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate
C22075  Staphyloferrin B
C22101  N5-Citryl-D-ornithine
C22102  Staphyloferrin A
C22137  4-Chloro-L-lysine
C22138  L-Propargylglycine
C22139  gamma-L-Glutamyl-L-propargylglycine
C22140  L-gamma-Glutamyl-(3R)-L-beta-ethynylserine
C22141  L-beta-Ethynylserine
C22142  Cyclo(L-Trp-L-Phe)
C22143  N-Methyl-cyclo(L-Trp-L-Phe)
C22144  (-)-Ditryptophenaline
C22145  Fumiquinazoline F
C22146  Fumiquinazoline F-indoline-2',3'-diol
C22147  Fumiquinazoline A
C22148  Fumiquinazoline C
C22149  Fumiquinazoline D
C22449  Paerucumarin
Reference
PMID:24677498
  Authors
Saruwatari T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K
  Title
Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis.
  Journal
Chembiochem 15:656-9 (2014)
DOI:10.1002/cbic.201300751
Reference
PMID:24612080
  Authors
Lim FY, Ames B, Walsh CT, Keller NP
  Title
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
  Journal
Cell Microbiol 16:1267-83 (2014)
DOI:10.1111/cmi.12284
Reference
PMID:18689486
  Authors
Clarke-Pearson MF, Brady SF
  Title
Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas  aeruginosa.
  Journal
J Bacteriol 190:6927-30 (2008)
DOI:10.1128/JB.00801-08
Reference
PMID:19775248
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x
Reference
PMID:19635410
  Authors
Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
  Title
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
  Journal
Chem Biol 16:736-43 (2009)
DOI:10.1016/j.chembiol.2009.06.007
Reference
PMID:23653178
  Authors
Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y
  Title
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
  Journal
Angew Chem Int Ed Engl 52:6472-5 (2013)
DOI:10.1002/anie.201302406
Reference
PMID:17003031
  Authors
Suzuki H, Ohnishi Y, Furusho Y, Sakuda S, Horinouchi S
  Title
Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes.
  Journal
J Biol Chem 281:36944-51 (2006)
DOI:10.1074/jbc.M608103200
Reference
PMID:19138128
  Authors
Cotton JL, Tao J, Balibar CJ
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
Reference
PMID:30867596
  Authors
Marchand JA, Neugebauer ME, Ing MC, Lin CI, Pelton JG, Chang MCY
  Title
Discovery of a pathway for terminal-alkyne amino acid biosynthesis.
  Journal
Nature 567:420-424 (2019)
DOI:10.1038/s41586-019-1020-y
Reference
PMID:1393837
  Authors
Neilands JB
  Title
Mechanism and regulation of synthesis of aerobactin in Escherichia coli K12 (pColV-K30).
  Journal
Can J Microbiol 38:728-33 (1992)
DOI:10.1139/m92-119
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00250  Alanine, aspartate and glutamate metabolism
rn00260  Glycine, serine and threonine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00900  Terpenoid backbone biosynthesis
KO pathway
ko00997   

DBGET integrated database retrieval system