KEGG   PATHWAY: rno00190
Entry
rno00190                    Pathway                                
Name
Oxidative phosphorylation - Rattus norvegicus (rat)
Class
Metabolism; Energy metabolism
Pathway map
rno00190  Oxidative phosphorylation
rno00190

Module
rno_M00142  NADH:ubiquinone oxidoreductase, mitochondria [PATH:rno00190]
rno_M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:rno00190]
rno_M00146  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:rno00190]
rno_M00148  Succinate dehydrogenase (ubiquinone) [PATH:rno00190]
rno_M00151  Cytochrome bc1 complex respiratory unit [PATH:rno00190]
rno_M00152  Cytochrome bc1 complex [PATH:rno00190]
rno_M00154  Cytochrome c oxidase [PATH:rno00190]
rno_M00158  F-type ATPase, eukaryotes [PATH:rno00190]
rno_M00160  V-type ATPase, eukaryotes [PATH:rno00190]
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
26193  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
26194  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26199  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26201  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26200  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26202  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26203  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
301458  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
289218  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
295923  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
499529  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
362588  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
679739  Ndufs6; NADH:ubiquinone oxidoreductase subunit S6-like 1 [KO:K03939]
362837  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
293652  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
293655  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
81728  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
64539  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2 [KO:K03944]
363441  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
291660  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
120099907  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
691001  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
681024  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100362331  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
25488  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
315167  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
299643  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
120101567  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
296658  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
362440  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
316632  Ndufa10l1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like [KO:K03954]
678759  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
293453  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
301123  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
299739  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100911483  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
362344  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
301427  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103690609  Ndufb3l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
103694107  Ndufb3l3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
103691697  Ndufb3l2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
120098318  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
288088  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
499131  Ndufb4l3; similar to NADH:ubiquinone oxidoreductase B15 subunit [KO:K03960]
100361934  Ndufb4l4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
103691107  Ndufb4l5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
120094308  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
501886  Ndufb4l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
294964  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
297990  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
361385  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
293991  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
299954  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
681418  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
299310  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
689938  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
293130  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
157074  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
298596  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
289217  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
363061  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
291103  Uqcrfs1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
26192  CYTB; cytochrome b [KO:K00412]
300047  Cyc1; cytochrome c-1 [KO:K00413]
301011  Uqcrc1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414]
293448  Uqcrc2; cytochrome b-c1 complex subunit 2, mitochondrial precursor [KO:K00415]
366448  Uqcrh; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
362897  Uqcrb; cytochrome b-c1 complex subunit 7 [KO:K00417]
103693740  Uqcrbl2; cytochrome b-c1 complex subunit 7-like [KO:K00417]
685596  Uqcrbl1; cytochrome b-c1 complex subunit 7-like [KO:K00417]
497902  Uqcrq; cytochrome b-c1 complex subunit 8 [KO:K00418]
685322  Uqcr10; ubiquinol-cytochrome c reductase complex 7.2kDa protein [KO:K00419]
690848  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
120097699  cytochrome b-c1 complex subunit 10-like [KO:K00420]
100362798  Uqcr11l1; cytochrome b-c1 complex subunit 10-like [KO:K00420]
691853  Cox10; cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 [KO:K02257] [EC:2.5.1.141]
26204  COX3; cytochrome c oxidase subunit III [KO:K02262]
26195  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26198  COX2; cytochrome c oxidase subunit II [KO:K02261]
84683  Cox4i2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor [KO:K02263]
29445  Cox4i1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
252934  Cox5a; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
100361008  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
94194  Cox5b; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
25278  Cox6a2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
25282  Cox6a1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
688869  Cox6b1; cytochrome c oxidase subunit 6B1 [KO:K02267]
654441  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
120103152  cytochrome c oxidase subunit 6B1-like [KO:K02267]
54322  Cox6c; cytochrome c oxidase subunit 6C-2 [KO:K02268]
120098258  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
29507  Cox7a2; cytochrome c oxidase subunit 7A2, mitochondrial precursor [KO:K02270]
298762  Cox7a2l; cytochrome c oxidase subunit 7A2 like isoform 1 [KO:K02270]
688386  Cox7a2l2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
687508  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
303393  Cox7b; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
100361960  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
100188937  Cox7c; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100360357  Cox7cl1; cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
120095266  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
25250  Cox8b; cytochrome c oxidase subunit 8B, mitochondrial precursor [KO:K02273]
360229  Cox8c; cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
171335  Cox8a; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
103693419  Cox11; cytochrome c oxidase copper chaperone COX11 [KO:K02258]
309391  Cox15; COX15 homolog [KO:K02259] [EC:1.17.99.9]
89786  Cox17; COX17 homolog, cytochrome c oxidase assembly protein [KO:K02260]
25309  Cycs; cytochrome c, somatic [KO:K08738]
25310  Cyct; cytochrome c, testis-specific [KO:K08738]
120099910  cytochrome c, somatic-like [KO:K08738]
690675  Cycsl2; cytochrome c, somatic-like [KO:K08738]
679794  Cycsl1; cytochrome c, somatic-like [KO:K08738]
290019  Cycsl3; cytochrome c, somatic-like [KO:K08738]
65262  Atp5f1a; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
171374  Atp5f1b; ATP synthase subunit beta, mitochondrial precursor [KO:K02133] [EC:7.1.2.2]
116550  Atp5f1c; ATP synthase subunit gamma, mitochondrial [KO:K02136]
245965  Atp5f1d; ATP synthase subunit delta, mitochondrial precursor [KO:K02134]
245958  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100361879  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
192241  Atp5po; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
26197  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
171375  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127]
171082  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128]
114630  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128]
29754  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128]
100361833  Atp5mc2l1; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
499512  Atp5mc2l2; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
689961  Atp5mc1l1; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
366614  Atp5mc1l2; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
120098314  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
641434  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
688022  Atp5pdl1; ATP synthase subunit d, mitochondrial-like [KO:K02138]
140608  Atp5me; ATP synthase subunit e, mitochondrial [KO:K02129]
120095138  LOW QUALITY PROTEIN: ATP synthase subunit e, mitochondrial-like [KO:K02129]
690441  Atp5mf; ATP synthase subunit f, mitochondrial [KO:K02130]
300677  Atp5mg; ATP synthase subunit g, mitochondrial [KO:K02140]
120097069  ATP synthase subunit g, mitochondrial-like [KO:K02140]
679690  Atp5mgl3; ATP synthase subunit g, mitochondrial-like [KO:K02140]
680026  Atp5mgl4; ATP synthase subunit g, mitochondrial-like [KO:K02140]
120094169  ATP synthase subunit g, mitochondrial-like [KO:K02140]
120095262  ATP synthase subunit g, mitochondrial-like [KO:K02140]
94271  Atp5pf; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131]
26196  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
685232  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117596  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
312488  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
299971  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
362802  Atp6v1c2; V-type proton ATPase subunit C 2 [KO:K02148]
299159  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
297566  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
366545  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
116664  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
289407  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
298103  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
368044  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
501686  Atp6v1g1l1; V-type proton ATPase subunit G 1-like [KO:K02152]
297797  Atp6v1h; V-type proton ATPase subunit H isoform 1 [KO:K02144]
29757  Atp6v0a1; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
296981  Atp6v0a4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
293650  Tcirg1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
116455  Atp6v0a2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
170667  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
298451  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
291969  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
297932  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
94170  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
436582  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
83615  Atp6ap1; V-type proton ATPase subunit S1 precursor [KO:K03662]
24216  Atp4a; potassium-transporting ATPase alpha chain 1 [KO:K01542] [EC:7.2.2.19]
24217  Atp4b; potassium-transporting ATPase subunit beta [KO:K01543] [EC:7.2.2.19]
171028  Atp12a; potassium-transporting ATPase alpha chain 2 isoform b [KO:K01544] [EC:7.2.2.19]
294504  Ppa1; inorganic pyrophosphatase [KO:K01507] [EC:3.6.1.1]
310856  Ppa2; inorganic pyrophosphatase 2, mitochondrial [KO:K01507] [EC:3.6.1.1]
361663  Lhpp; phospholysine phosphohistidine inorganic pyrophosphate phosphatase [KO:K11725] [EC:3.6.1.1 3.1.3.-]
Compound
C00001  H2O
C00002  ATP
C00003  NAD+
C00004  NADH
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00042  Succinate
C00080  H+
C00122  Fumarate
C00536  Triphosphate
Reference
PMID:16469879
  Authors
Sazanov LA, Hinchliffe P.
  Title
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
  Journal
Science 311:1430-6 (2006)
DOI:10.1126/science.1123809
Reference
PMID:16584177
  Authors
Hinchliffe P, Carroll J, Sazanov LA.
  Title
Identification of a novel subunit of respiratory complex I from Thermus thermophilus.
  Journal
Biochemistry 45:4413-20 (2006)
DOI:10.1021/bi0600998
KO pathway
ko00190   
LinkDB

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