KEGG   PATHWAY: rros00260
Entry
rros00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium rosettiformans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rros00260  Glycine, serine and threonine metabolism
rros00260

Module
rros_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rros00260]
rros_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rros00260]
rros_M00555  Betaine biosynthesis, choline => betaine [PATH:rros00260]
rros_M00621  Glycine cleavage system [PATH:rros00260]
rros_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:rros00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium rosettiformans [GN:rros]
Gene
D4A92_04085  aspartate kinase [KO:K00928] [EC:2.7.2.4]
D4A92_05860  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
D4A92_16675  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
D4A92_12355  homoserine kinase [KO:K02204] [EC:2.7.1.39]
D4A92_12400  threonine synthase [KO:K01733] [EC:4.2.3.1]
D4A92_01065  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
D4A92_14815  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
D4A92_01900  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
D4A92_07385  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
D4A92_03980  glycerate kinase [KO:K11529] [EC:2.7.1.165]
D4A92_07325  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
D4A92_17705  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
D4A92_00600  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
D4A92_00605  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
D4A92_18990  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
D4A92_07985  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
D4A92_07980  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
D4A92_02685  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
D4A92_04555  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
D4A92_16460  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
D4A92_16470  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
D4A92_03170  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
D4A92_04735  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
D4A92_17175  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
D4A92_16465  gcvH; glycine cleavage system protein GcvH [KO:K02437]
D4A92_14265  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
D4A92_12850  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
D4A92_12865  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
D4A92_11945  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
D4A92_11950  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
D4A92_00005  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
D4A92_01240  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
D4A92_01250  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
D4A92_01235  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
D4A92_01245  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
D4A92_17830  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
D4A92_16050  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
D4A92_05515  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
D4A92_06090  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
D4A92_06085  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rros00010  Glycolysis / Gluconeogenesis
rros00020  Citrate cycle (TCA cycle)
rros00230  Purine metabolism
rros00250  Alanine, aspartate and glutamate metabolism
rros00270  Cysteine and methionine metabolism
rros00290  Valine, leucine and isoleucine biosynthesis
rros00300  Lysine biosynthesis
rros00330  Arginine and proline metabolism
rros00460  Cyanoamino acid metabolism
rros00470  D-Amino acid metabolism
rros00564  Glycerophospholipid metabolism
rros00600  Sphingolipid metabolism
rros00620  Pyruvate metabolism
rros00630  Glyoxylate and dicarboxylate metabolism
rros00640  Propanoate metabolism
rros00680  Methane metabolism
rros00860  Porphyrin metabolism
rros00920  Sulfur metabolism
KO pathway
ko00260   
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