KEGG   PATHWAY: sasa00062
Entry
sasa00062                   Pathway                                
Name
Fatty acid elongation - Salmo salar (Atlantic salmon)
Class
Metabolism; Lipid metabolism
Pathway map
sasa00062  Fatty acid elongation
sasa00062

Module
sasa_M00085  Fatty acid elongation in mitochondria [PATH:sasa00062]
sasa_M00415  Fatty acid elongation in endoplasmic reticulum [PATH:sasa00062]
Other DBs
GO: 0030497
Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106580430  THIM; 3-ketoacyl-CoA thiolase, mitochondrial-like [KO:K07508] [EC:2.3.1.16]
106585052  THIM; 3-ketoacyl-CoA thiolase, mitochondrial-like [KO:K07508] [EC:2.3.1.16]
106608385  hadhb; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [KO:K07509] [EC:2.3.1.16]
106610339  hadh; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
106603767  trifunctional enzyme subunit alpha, mitochondrial-like [KO:K07515] [EC:4.2.1.17 1.1.1.211]
106611334  ECHA; trifunctional enzyme subunit alpha, mitochondrial-like [KO:K07515] [EC:4.2.1.17 1.1.1.211]
100194570  echs1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]
106581738  trans-2-enoyl-CoA reductase, mitochondrial-like [KO:K07512] [EC:1.3.1.- 1.3.1.38]
106605110  mecr; mitochondrial trans-2-enoyl-CoA reductase [KO:K07512] [EC:1.3.1.- 1.3.1.38]
106607757  trans-2-enoyl-CoA reductase, mitochondrial-like [KO:K07512] [EC:1.3.1.- 1.3.1.38]
106570032  PPT1; palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
106570067  lysosomal thioesterase PPT2-A-like [KO:K01074] [EC:3.1.2.22]
100196302  ppt2a; Lysosomal thioesterase PPT2-A [KO:K01074] [EC:3.1.2.22]
106588481  PPT1; palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
106588210  lysosomal thioesterase PPT2-A-like [KO:K01074] [EC:3.1.2.22]
106599266  elongation of very long chain fatty acids protein 1-like [KO:K10247] [EC:2.3.1.199]
106569200  elongation of very long chain fatty acids protein 1-like [KO:K10247] [EC:2.3.1.199]
100195361  elov7; Elongation of very long chain fatty acids protein 7 [KO:K10247] [EC:2.3.1.199]
100286454  elov1; Elongation of very long chain fatty acids protein 1 [KO:K10247] [EC:2.3.1.199]
100192341  elovl2; ELOVL fatty acid elongase 2 [KO:K10205] [EC:2.3.1.199]
106606161  elongation of very long chain fatty acids protein 4-like [KO:K10249] [EC:2.3.1.199]
106569295  elongation of very long chain fatty acids protein 4-like [KO:K10249] [EC:2.3.1.199]
106571493  elongation of very long chain fatty acids protein 4-like [KO:K10249] [EC:2.3.1.199]
106574012  elongation of very long chain fatty acids protein 4-like [KO:K10249] [EC:2.3.1.199]
106613536  elongation of very long chain fatty acids protein 4-like [KO:K10249] [EC:2.3.1.199]
106597646  elongation of very long chain fatty acids protein 4-like [KO:K10249] [EC:2.3.1.199]
106597446  elongation of very long chain fatty acids protein 4-like [KO:K10249] [EC:2.3.1.199]
100500788  elovl4; elongation of very long chain fatty acids-like 4 [KO:K10249] [EC:2.3.1.199]
100136433  elvol5a; polyunsaturated fatty acid elongase [KO:K10244] [EC:2.3.1.199]
100192340  elovl5b; polyunsaturated fatty acid elongase elovl5b [KO:K10244] [EC:2.3.1.199]
106606039  elongation of very long chain fatty acids protein 6-like [KO:K10203] [EC:2.3.1.199]
106604515  elongation of very long chain fatty acids protein 6 [KO:K10203] [EC:2.3.1.199]
106611586  elovl6; ELOVL fatty acid elongase 6 [KO:K10203] [EC:2.3.1.199]
106579283  elongation of very long chain fatty acids protein 6-like [KO:K10203] [EC:2.3.1.199]
106589262  elongation of very long chain fatty acids protein 6-like [KO:K10203] [EC:2.3.1.199]
106571348  elongation of very long chain fatty acids protein 7-like [KO:K10250] [EC:2.3.1.199]
106580590  elongation of very long chain fatty acids protein 7-like [KO:K10250] [EC:2.3.1.199]
106585161  elongation of very long chain fatty acids protein 7-like [KO:K10250] [EC:2.3.1.199]
106603577  very-long-chain 3-oxoacyl-CoA reductase-like [KO:K10251] [EC:1.1.1.62 1.1.1.330]
106603598  very-long-chain 3-oxoacyl-CoA reductase-B-like [KO:K10251] [EC:1.1.1.62 1.1.1.330]
106562710  very-long-chain 3-oxoacyl-CoA reductase-B-like [KO:K10251] [EC:1.1.1.62 1.1.1.330]
106561091  hsd17b12; hydroxysteroid 17-beta dehydrogenase 12 [KO:K10251] [EC:1.1.1.62 1.1.1.330]
100196617  dh12b; Estradiol 17-beta-dehydrogenase 12-B [KO:K10251] [EC:1.1.1.62 1.1.1.330]
106562668  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase-like [KO:K10703] [EC:4.2.1.134]
106578705  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1-like [KO:K10703] [EC:4.2.1.134]
106577593  hacd4; 3-hydroxyacyl-CoA dehydratase 4 [KO:K10703] [EC:4.2.1.134]
106590135  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1-like [KO:K10703] [EC:4.2.1.134]
100286513  hacd3; 3-hydroxyacyl-CoA dehydratase 3 [KO:K10703] [EC:4.2.1.134]
106587973  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase-like [KO:K10703] [EC:4.2.1.134]
106582347  hacd2; 3-hydroxyacyl-CoA dehydratase 2 [KO:K10703] [EC:4.2.1.134]
100196500  phs1; PHS1 protein [KO:K10703] [EC:4.2.1.134]
106569794  very-long-chain enoyl-CoA reductase-like [KO:K10258] [EC:1.3.1.93]
106590656  very-long-chain enoyl-CoA reductase-like [KO:K10258] [EC:1.3.1.93]
106564267  tecr; trans-2,3-enoyl-CoA reductase [KO:K10258] [EC:1.3.1.93]
106601160  uncharacterized LOC106601160 [KO:K01068] [EC:3.1.2.2]
106608160  acyl-coenzyme A thioesterase 1-like [KO:K01068] [EC:3.1.2.2]
106607018  putative acyl-coenzyme A thioesterase 6 [KO:K01068] [EC:3.1.2.2]
106571092  acyl-coenzyme A thioesterase 1-like [KO:K01068] [EC:3.1.2.2]
106565402  acyl-coenzyme A thioesterase 1-like [KO:K01068] [EC:3.1.2.2]
106576041  acyl-coenzyme A thioesterase 5-like [KO:K01068] [EC:3.1.2.2]
106576042  acyl-coenzyme A thioesterase 5-like [KO:K01068] [EC:3.1.2.2]
106571059  acyl-coenzyme A thioesterase 1-like [KO:K01068] [EC:3.1.2.2]
100194827  acot5; Acyl-coenzyme A thioesterase 5 [KO:K01068] [EC:3.1.2.2]
106584566  acyl-coenzyme A thioesterase 1-like [KO:K01068] [EC:3.1.2.2]
106584569  acyl-coenzyme A thioesterase 4-like [KO:K01068] [EC:3.1.2.2]
106572204  acot7; acyl-CoA thioesterase 7 [KO:K17360] [EC:3.1.2.2]
106575342  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
106592246  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
Compound
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00083  Malonyl-CoA
C00136  Butanoyl-CoA
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00249  Hexadecanoic acid
C00264  3-Oxoacyl-CoA
C00605  2,3-Dehydroacyl-CoA
C00638  Long-chain fatty acid
C00640  (3S)-3-Hydroxyacyl-CoA
C00658  trans-2,3-Dehydroacyl-CoA
C01832  Lauroyl-CoA
C01944  Octanoyl-CoA
C02593  Tetradecanoyl-CoA
C02843  Long-chain acyl-CoA
C03221  2-trans-Dodecenoyl-CoA
C05258  (S)-3-Hydroxyhexadecanoyl-CoA
C05259  3-Oxopalmitoyl-CoA
C05260  (S)-3-Hydroxytetradecanoyl-CoA
C05261  3-Oxotetradecanoyl-CoA
C05262  (S)-3-Hydroxydodecanoyl-CoA
C05263  3-Oxododecanoyl-CoA
C05264  (S)-Hydroxydecanoyl-CoA
C05265  3-Oxodecanoyl-CoA
C05266  (S)-3-Hydroxyoctanoyl-CoA
C05267  3-Oxooctanoyl-CoA
C05268  (S)-Hydroxyhexanoyl-CoA
C05269  3-Oxohexanoyl-CoA
C05270  Hexanoyl-CoA
C05271  trans-Hex-2-enoyl-CoA
C05272  trans-Hexadec-2-enoyl-CoA
C05273  trans-Tetradec-2-enoyl-CoA
C05274  Decanoyl-CoA
C05275  trans-Dec-2-enoyl-CoA
C05276  trans-Oct-2-enoyl-CoA
C20876  Very-long-chain acyl-CoA
C20877  Very-long-chain 3-oxoacyl-CoA
C20878  Very-long-chain (3R)-3-hydroxyacyl-CoA
C20879  Very-long-chain trans-2,3-dehydroacyl-CoA
Reference
PMID:4387390
  Authors
Seubert W, Lamberts I, Kramer R, Ohly B
  Title
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.
  Journal
Biochim Biophys Acta 164:498-517 (1968)
DOI:10.1016/0005-2760(68)90180-X
Reference
PMID:7150615
  Authors
El-Fakhri M, Middleton B
  Title
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
  Journal
Biochim Biophys Acta 713:270-9 (1982)
DOI:10.1016/0005-2760(82)90244-2
Reference
PMID:8190743
  Authors
Cassagne C, Lessire R, Bessoule JJ, Moreau P, Creach A, Schneider F, Sturbois B
  Title
Biosynthesis of very long chain fatty acids in higher plants.
  Journal
Prog Lipid Res 33:55-69 (1994)
DOI:10.1016/0163-7827(94)90009-4
Reference
PMID:16564093
  Authors
Jakobsson A, Westerberg R, Jacobsson A.
  Title
Fatty acid elongases in mammals: their regulation and roles in metabolism.
  Journal
Prog Lipid Res 45:237-49 (2006)
DOI:10.1016/j.plipres.2006.01.004
Reference
PMID:16765910
  Authors
Blacklock BJ, Jaworski JG
  Title
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases.
  Journal
Biochem Biophys Res Commun 346:583-90 (2006)
DOI:10.1016/j.bbrc.2006.05.162
Reference
PMID:16866954
  Authors
Shepherd T, Wynne Griffiths D
  Title
The effects of stress on plant cuticular waxes.
  Journal
New Phytol 171:469-99 (2006)
DOI:10.1111/j.1469-8137.2006.01826.x
Reference
PMID:17719534
  Authors
Riezman H
  Title
The long and short of fatty acid synthesis.
  Journal
Cell 130:587-8 (2007)
DOI:10.1016/j.cell.2007.08.008
Reference
PMID:19649180
  Authors
Raffaele S, Leger A, Roby D
  Title
Very long chain fatty acid and lipid signaling in the response of plants to pathogens.
  Journal
Plant Signal Behav 4:94-9 (2009)
DOI:10.4161/psb.4.2.7580
Related
pathway
sasa00071  Fatty acid degradation
KO pathway
ko00062   
LinkDB

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