KEGG   PATHWAY: scac00983
Entry
scac00983                   Pathway                                
Name
Drug metabolism - other enzymes - Stomoxys calcitrans (stable fly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
scac00983  Drug metabolism - other enzymes
scac00983

Organism
Stomoxys calcitrans (stable fly) [GN:scac]
Gene
106092802  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
106082311  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
106082379  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106082452  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106082772  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106082773  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106082775  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106087981  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106088014  indole-3-acetaldehyde oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106089636  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
106093551  esterase-5B-like [KO:K01044] [EC:3.1.1.1]
106093552  esterase-5B-like [KO:K01044] [EC:3.1.1.1]
106093555  esterase-5A-like isoform X1 [KO:K01044] [EC:3.1.1.1]
106089514  neuroligin 4-like [KO:K01044] [EC:3.1.1.1]
106082295  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
106082298  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
106082446  UDP-glucuronosyltransferase 2B13-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106082447  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
106094060  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
106094062  UDP-glucuronosyltransferase 2B13-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106094063  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
106085137  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106085138  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106094226  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
106095314  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106087798  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
106088341  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
106088342  UDP-glucuronosyltransferase 2B13 [KO:K00699] [EC:2.4.1.17]
106080829  UDP-glucuronosyltransferase 1-1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106080965  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
106081282  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
106090639  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
106090641  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
106094363  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
106087485  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
106081367  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
106081466  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
106092277  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
106081829  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
106081852  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
106092257  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
106081621  probable uridine-cytidine kinase [KO:K00876] [EC:2.7.1.48]
106096345  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
106089955  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
106091606  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106085380  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106093034  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
106096075  uncharacterized protein LOC106096075 isoform X1 [KO:K00940] [EC:2.7.4.6]
106088974  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
106081305  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106085852  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
106087103  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
106083097  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
106083098  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
106083100  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
106083101  glutathione S-transferase D7 isoform X1 [KO:K00799] [EC:2.5.1.18]
106083103  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
106083104  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
106083105  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
106083134  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
106083135  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
106083136  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106083137  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106083138  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
106083139  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
106083142  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
106083143  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
106083144  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
106083848  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106083849  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106083852  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106083863  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106084465  pyrimidodiazepine synthase [KO:K00799] [EC:2.5.1.18]
106085264  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
106094513  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106094514  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106094517  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106094848  microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
106085607  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106085656  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
106087960  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106087961  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106087962  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106080677  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
106080775  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
106089180  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106089181  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106089182  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106081428  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
106081631  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106081632  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106081635  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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