KEGG   PATHWAY: sdw00230
Entry
sdw00230                    Pathway                                
Name
Purine metabolism - Streptomyces decoyicus
Class
Metabolism; Nucleotide metabolism
Pathway map
sdw00230  Purine metabolism
sdw00230

Module
sdw_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:sdw00230]
sdw_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:sdw00230]
sdw_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:sdw00230]
sdw_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:sdw00230]
sdw_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sdw00230]
sdw_M00546  Purine degradation, xanthine => urea [PATH:sdw00230]
sdw_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:sdw00230]
sdw_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:sdw00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces decoyicus [GN:sdw]
Gene
K7C20_05020  prs; ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
K7C20_15245  ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
K7C20_17630  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
K7C20_17725  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
K7C20_22720  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
K7C20_17650  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
K7C20_17660  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
K7C20_17655  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
K7C20_17625  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
K7C20_14605  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
K7C20_14600  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
K7C20_17705  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
K7C20_33985  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
K7C20_22725  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
K7C20_05030  hypothetical protein [KO:K00759] [EC:2.4.2.7]
K7C20_06320  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
K7C20_21570  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
K7C20_06630  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
K7C20_13595  HAD-IIA family hydrolase [KO:K02566] [EC:3.1.3.5]
K7C20_23360  purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
K7C20_09870  pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
K7C20_32985  nucleoside hydrolase [KO:K25589] [EC:3.2.2.2 3.2.2.3]
K7C20_20890  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
K7C20_16315  GuaB3 family IMP dehydrogenase-related protein [KO:K00088] [EC:1.1.1.205]
K7C20_16320  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
K7C20_12665  ndk; nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
K7C20_13770  rdgB; RdgB/HAM1 family non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
K7C20_28995  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
K7C20_32360  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
K7C20_33185  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
K7C20_35200  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
K7C20_28990  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
K7C20_32355  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
K7C20_33190  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
K7C20_35195  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
K7C20_28985  2Fe-2S iron-sulfur cluster binding domain-containing protein [KO:K13483]
K7C20_33195  2Fe-2S iron-sulfur cluster binding domain-containing protein [KO:K13483]
K7C20_35190  (2Fe-2S)-binding protein [KO:K13483]
K7C20_22525  guaA; glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
K7C20_06085  GuaB1 family IMP dehydrogenase-related protein [KO:K26110] [EC:1.7.1.7]
K7C20_05265  nucleoside deaminase [KO:K01487] [EC:3.5.4.3]
K7C20_06145  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
K7C20_24715  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
K7C20_27410  vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
K7C20_24710  ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
K7C20_25765  dgt; dNTP triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
K7C20_11885  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
K7C20_27355  HD domain-containing protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
K7C20_06315  RelA/SpoT family protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
K7C20_21145  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
K7C20_15090  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
K7C20_23450  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
K7C20_17775  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
K7C20_04355  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
K7C20_32520  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
K7C20_10240  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
K7C20_16730  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
K7C20_23270  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
K7C20_00980  hypothetical protein [KO:K01488] [EC:3.5.4.4]
K7C20_11895  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
K7C20_09450  5'-nucleotidase C-terminal domain-containing protein [KO:K01119] [EC:3.1.4.16 3.1.3.6]
K7C20_16535  adenylate kinase [KO:K00939] [EC:2.7.4.3]
K7C20_06410  HIT domain-containing protein [KO:K19710] [EC:2.7.7.53]
K7C20_28820  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
K7C20_28810  50S ribosome-binding GTPase [KO:K00956] [EC:2.7.7.4]
K7C20_28815  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
K7C20_29340  pucL; urate oxidase [KO:K00365] [EC:1.7.3.3]
K7C20_29335  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
K7C20_23115  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
K7C20_29330  uraD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
K7C20_29415  aspartate/glutamate racemase family protein [KO:K16841] [EC:5.1.99.3]
K7C20_29425  allB; allantoinase AllB [KO:K01466] [EC:3.5.2.5]
K7C20_29430  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
K7C20_12830  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
K7C20_26150  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
K7C20_34190  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
K7C20_01825  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
K7C20_34185  urease subunit beta [KO:K01429] [EC:3.5.1.5]
K7C20_34180  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
K7C20_26145  ureA; urease subunit gamma [KO:K14048] [EC:3.5.1.5]
K7C20_01820  urease subunit gamma [KO:K14048] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
sdw00030  Pentose phosphate pathway
sdw00220  Arginine biosynthesis
sdw00250  Alanine, aspartate and glutamate metabolism
sdw00260  Glycine, serine and threonine metabolism
sdw00340  Histidine metabolism
sdw00630  Glyoxylate and dicarboxylate metabolism
sdw00730  Thiamine metabolism
sdw00740  Riboflavin metabolism
sdw00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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