KEGG   PATHWAY: sech00260
Entry
sech00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas aeruginosa B18
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sech00260  Glycine, serine and threonine metabolism
sech00260

Module
sech_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sech00260]
sech_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sech00260]
sech_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sech00260]
sech_M00555  Betaine biosynthesis, choline => betaine [PATH:sech00260]
sech_M00621  Glycine cleavage system [PATH:sech00260]
sech_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:sech00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas aeruginosa B18 [GN:sech]
Gene
B18_16170  aspartate kinase [KO:K00928] [EC:2.7.2.4]
B18_28575  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
B18_01665  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
B18_08285  homoserine kinase type II [KO:K02204] [EC:2.7.1.39]
B18_20610  phosphoserine / homoserine phosphotransferase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
B18_01660  threonine synthase [KO:K01733] [EC:4.2.3.1]
B18_16160  threonine aldolase [KO:K01620] [EC:4.1.2.48]
B18_08700  threonine aldolase [KO:K01620] [EC:4.1.2.48]
B18_13005  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B18_24305  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B18_08690  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B18_12880  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
B18_02520  glyoxylate/hydroxypyruvate/2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
B18_16905  glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
B18_19270  glycerate 2-kinase [KO:K11529] [EC:2.7.1.165]
B18_10190  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
B18_06305  D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B18_28805  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
B18_11045  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
B18_05760  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
B18_24310  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
B18_09740  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
B18_24295  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
B18_09730  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
B18_11720  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
B18_19720  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
B18_23325  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
B18_24315  glycine cleavage system H protein [KO:K02437]
B18_09735  glycine cleavage system H protein [KO:K02437]
B18_11965  glycine cleavage system protein H [KO:K02437]
B18_12495  CDP-diacylglycerol---serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
B18_08910  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
B18_08905  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B18_08715  glycine betaine catabolism A [KO:K00479] [EC:1.14.13.251]
B18_08710  glycine betaine catabolism B [KO:K21832] [EC:1.14.13.251]
B18_08780  dimethylglycine catabolism A [KO:K21833] [EC:1.5.7.3]
B18_08775  dimethylglycine catabolism B [KO:K21834]
B18_08770  electron transfer flavoprotein alpha subunit [KO:K25960]
B18_08765  electron transfer flavoprotein beta subunit [KO:K25961]
B18_08675  sarcosine oxidase, subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
B18_08685  sarcosine oxidase, subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
B18_08670  sarcosine oxidase, subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
B18_08680  sarcosine oxidase, subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
B18_05870  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
B18_05865  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
B18_24300  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
B18_08875  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
B18_15900  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B18_18370  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B18_06225  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B18_29790  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
B18_07730  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
B18_07725  tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
B18_23070  diaminobutyrate-2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
B18_24145  diaminobutyrate-2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sech00010  Glycolysis / Gluconeogenesis
sech00020  Citrate cycle (TCA cycle)
sech00230  Purine metabolism
sech00250  Alanine, aspartate and glutamate metabolism
sech00270  Cysteine and methionine metabolism
sech00290  Valine, leucine and isoleucine biosynthesis
sech00300  Lysine biosynthesis
sech00330  Arginine and proline metabolism
sech00460  Cyanoamino acid metabolism
sech00470  D-Amino acid metabolism
sech00564  Glycerophospholipid metabolism
sech00600  Sphingolipid metabolism
sech00620  Pyruvate metabolism
sech00630  Glyoxylate and dicarboxylate metabolism
sech00640  Propanoate metabolism
sech00680  Methane metabolism
sech00860  Porphyrin metabolism
sech00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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