KEGG   PATHWAY: sfp00260
Entry
sfp00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces flavofungini
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sfp00260  Glycine, serine and threonine metabolism
sfp00260

Module
sfp_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sfp00260]
sfp_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sfp00260]
sfp_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sfp00260]
sfp_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sfp00260]
sfp_M00621  Glycine cleavage system [PATH:sfp00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces flavofungini [GN:sfp]
Gene
QUY26_18035  aspartate kinase [KO:K00928] [EC:2.7.2.4]
QUY26_18030  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
QUY26_26070  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
QUY26_11970  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
QUY26_11960  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
QUY26_11965  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
QUY26_21840  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
QUY26_25775  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
QUY26_35960  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
QUY26_11155  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
QUY26_11920  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
QUY26_14635  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
QUY26_35745  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
QUY26_07005  glycerate kinase [KO:K00865] [EC:2.7.1.165]
QUY26_29390  glycerate kinase [KO:K00865] [EC:2.7.1.165]
QUY26_21570  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
QUY26_03300  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QUY26_10895  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QUY26_22280  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
QUY26_31425  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
QUY26_19805  HAD-IB family phosphatase [KO:K01079] [EC:3.1.3.3]
QUY26_05610  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
QUY26_05615  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
QUY26_39235  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
QUY26_08085  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
QUY26_34340  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
QUY26_11145  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
QUY26_29220  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QUY26_35390  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QUY26_11150  gcvH; glycine cleavage system protein GcvH [KO:K02437]
QUY26_05860  FAD-dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
QUY26_07000  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
QUY26_10140  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
QUY26_10205  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
QUY26_14810  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
QUY26_39420  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
QUY26_34160  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
QUY26_34155  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
QUY26_14660  class I SAM-dependent methyltransferase [KO:K18897] [EC:2.1.1.157]
QUY26_07530  methyltransferase domain-containing protein [KO:K24071] [EC:2.1.1.156 2.1.1.157]
QUY26_23730  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
QUY26_19825  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
QUY26_11160  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
QUY26_13945  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
QUY26_29970  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
QUY26_29965  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
QUY26_09450  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
QUY26_31035  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
QUY26_31040  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
QUY26_31030  ectoine synthase [KO:K06720] [EC:4.2.1.108]
QUY26_31025  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
QUY26_25430  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sfp00010  Glycolysis / Gluconeogenesis
sfp00020  Citrate cycle (TCA cycle)
sfp00230  Purine metabolism
sfp00250  Alanine, aspartate and glutamate metabolism
sfp00270  Cysteine and methionine metabolism
sfp00290  Valine, leucine and isoleucine biosynthesis
sfp00300  Lysine biosynthesis
sfp00330  Arginine and proline metabolism
sfp00460  Cyanoamino acid metabolism
sfp00470  D-Amino acid metabolism
sfp00564  Glycerophospholipid metabolism
sfp00600  Sphingolipid metabolism
sfp00620  Pyruvate metabolism
sfp00630  Glyoxylate and dicarboxylate metabolism
sfp00640  Propanoate metabolism
sfp00680  Methane metabolism
sfp00860  Porphyrin metabolism
sfp00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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