KEGG   PATHWAY: sgu00260
Entry
sgu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces glaucescens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sgu00260  Glycine, serine and threonine metabolism
sgu00260

Module
sgu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sgu00260]
sgu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sgu00260]
sgu_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sgu00260]
sgu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sgu00260]
sgu_M00621  Glycine cleavage system [PATH:sgu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces glaucescens [GN:sgu]
Gene
SGLAU_18310  ask; Aspartokinase [KO:K00928] [EC:2.7.2.4]
SGLAU_07125  putative aspartate kinase [KO:K00928] [EC:2.7.2.4]
SGLAU_18315  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SGLAU_07130  asd1; putative Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SGLAU_12085  asd2; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SGLAU_22955  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SGLAU_22965  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
SGLAU_22960  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
SGLAU_15425  threonine synthase [KO:K01733] [EC:4.2.3.1]
SGLAU_03960  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SGLAU_23010  glyA2; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SGLAU_23475  glyA3; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SGLAU_20810  glyA1; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SGLAU_27220  transferase [KO:K00865] [EC:2.7.1.165]
SGLAU_15700  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SGLAU_23690  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SGLAU_15160  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SGLAU_08005  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SGLAU_28440  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SGLAU_28435  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SGLAU_30855  flavin-binding oxidoreductase [KO:K00274] [EC:1.4.3.4]
SGLAU_26165  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
SGLAU_05485  gcvP; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
SGLAU_23485  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SGLAU_27175  lpdC; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SGLAU_09950  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SGLAU_23480  gcvH; Glycine cleavage system H protein [KO:K02437]
SGLAU_28175  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
SGLAU_01210  strB2; Putative inosamine-phosphate amidinotransferase 2 [KO:K00613] [EC:2.1.4.1]
SGLAU_27745  Glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
SGLAU_27225  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SGLAU_24335  prr1; gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SGLAU_24385  prr2; gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SGLAU_20750  gbsA; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SGLAU_14015  cbs; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SGLAU_16825  cysA; Putative cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
SGLAU_23470  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SGLAU_21350  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SGLAU_02675  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SGLAU_09230  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
SGLAU_09235  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
SGLAU_08330  ectB; putative Diaminobutyrate-2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
SGLAU_08325  ectA; putative L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
SGLAU_08335  ectC; putative L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
SGLAU_08340  ectD; putative Ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
SGLAU_12690  putative L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
SGLAU_09130  amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sgu00010  Glycolysis / Gluconeogenesis
sgu00020  Citrate cycle (TCA cycle)
sgu00230  Purine metabolism
sgu00250  Alanine, aspartate and glutamate metabolism
sgu00270  Cysteine and methionine metabolism
sgu00290  Valine, leucine and isoleucine biosynthesis
sgu00300  Lysine biosynthesis
sgu00330  Arginine and proline metabolism
sgu00460  Cyanoamino acid metabolism
sgu00470  D-Amino acid metabolism
sgu00564  Glycerophospholipid metabolism
sgu00600  Sphingolipid metabolism
sgu00620  Pyruvate metabolism
sgu00630  Glyoxylate and dicarboxylate metabolism
sgu00640  Propanoate metabolism
sgu00680  Methane metabolism
sgu00860  Porphyrin metabolism
sgu00920  Sulfur metabolism
KO pathway
ko00260   
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