KEGG   PATHWAY: sita00053
Entry
sita00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Setaria italica (foxtail millet)
Class
Metabolism; Carbohydrate metabolism
Pathway map
sita00053  Ascorbate and aldarate metabolism
sita00053

Module
sita_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:sita00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Setaria italica (foxtail millet) [GN:sita]
Gene
101773575  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
101780186  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
101784716  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
101774039  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
101765389  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
101760295  UDP-sugar pyrophosphorylase isoform X1 [KO:K12447] [EC:2.7.7.64]
101768879  LOW QUALITY PROTEIN: UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
101779430  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
101783587  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
101786191  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
101773538  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
101773952  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
101784005  aldose reductase [KO:K00002] [EC:1.1.1.2]
101762138  aldo-keto reductase family 4 member C10 isoform X1 [KO:K00002] [EC:1.1.1.2]
101762547  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
101773129  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
101760514  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
101776642  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
101758891  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
101777017  L-gulonolactone oxidase 2 [KO:K00103] [EC:1.1.3.8]
101760109  L-gulonolactone oxidase 2 [KO:K00103] [EC:1.1.3.8]
101767367  L-gulonolactone oxidase 2 [KO:K00103] [EC:1.1.3.8]
101756668  L-gulonolactone oxidase 2 [KO:K00103] [EC:1.1.3.8]
101778042  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
101772247  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
101752979  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
101785895  GDP-L-galactose phosphorylase 1 isoform X2 [KO:K14190] [EC:2.7.7.69]
101780560  GDP-L-galactose phosphorylase 1 isoform X1 [KO:K14190] [EC:2.7.7.69]
101757506  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
101785092  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
101782298  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
101762145  LOW QUALITY PROTEIN: L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
101756029  L-galactono-1,4-lactone dehydrogenase 2, mitochondrial [KO:K00225] [EC:1.3.2.3]
101769296  L-galactono-1,4-lactone dehydrogenase 2, mitochondrial [KO:K00225] [EC:1.3.2.3]
101779479  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
101770201  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
101784504  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
101764402  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
106804126  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
101756689  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
101758567  LOW QUALITY PROTEIN: monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
101773570  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
101785289  uncharacterized protein LOC101785289 [KO:K08232] [EC:1.6.5.4]
101780973  probable L-ascorbate peroxidase 8, chloroplastic [KO:K00434] [EC:1.11.1.11]
101761338  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
101754668  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
101760004  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
101786781  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
101769679  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
101753441  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
101776821  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
101759688  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
101769608  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
101773513  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
101762191  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
101773103  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
101761454  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
101755454  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
101761749  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
101762488  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
101777230  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
101782764  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
101762799  LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
101759802  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
sita00020  Citrate cycle (TCA cycle)
sita00040  Pentose and glucuronate interconversions
sita00051  Fructose and mannose metabolism
sita00520  Amino sugar and nucleotide sugar metabolism
sita00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

DBGET integrated database retrieval system