KEGG   PATHWAY: ska00230
Entry
ska00230                    Pathway                                
Name
Purine metabolism - Streptomyces kanamyceticus
Class
Metabolism; Nucleotide metabolism
Pathway map
ska00230  Purine metabolism
ska00230

Module
ska_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ska00230]
ska_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ska00230]
ska_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ska00230]
ska_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ska00230]
ska_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ska00230]
ska_M00546  Purine degradation, xanthine => urea [PATH:ska00230]
ska_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ska00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces kanamyceticus [GN:ska]
Gene
CP970_25735  ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
CP970_22595  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
CP970_22490  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
CP970_16745  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
CP970_22560  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269] [EC:6.3.5.3]
CP970_22550  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
CP970_22555  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265] [EC:6.3.5.3 3.5.1.2]
CP970_22600  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
CP970_26265  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
CP970_26270  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
CP970_22505  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
CP970_40875  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
CP970_16740  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
CP970_36280  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
CP970_23250  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
CP970_27550  HAD family hydrolase [KO:K02566] [EC:3.1.3.5]
CP970_16035  purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
CP970_32275  pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
CP970_19180  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
CP970_17015  GuaB3 family IMP dehydrogenase-related protein [KO:K00088] [EC:1.1.1.205]
CP970_17020  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
CP970_28955  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
CP970_27330  rdgB; RdgB/HAM1 family non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
CP970_43500  xanthine dehydrogenase small subunit [KO:K13481] [EC:1.17.1.4]
CP970_43495  xdhB; xanthine dehydrogenase molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
CP970_40450  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
CP970_41815  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
CP970_40445  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
CP970_41820  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
CP970_40440  (2Fe-2S)-binding protein [KO:K13483]
CP970_41825  oxidoreductase [KO:K13483]
CP970_16935  glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
CP970_36570  GuaB1 family IMP dehydrogenase-related protein [KO:K26110] [EC:1.7.1.7]
CP970_36470  guanylate kinase [KO:K00942] [EC:2.7.4.8]
CP970_11310  vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
CP970_14405  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
CP970_14410  ribonucleoside-diphosphate reductase [KO:K00526] [EC:1.17.4.1]
CP970_29850  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
CP970_11370  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
CP970_36290  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
CP970_18895  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
CP970_25915  Ppx/GppA family phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
CP970_15970  adenylate/guanylate cyclase domain-containing protein [KO:K01768] [EC:4.6.1.1]
CP970_20300  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
CP970_31865  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
CP970_16135  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
CP970_17485  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
CP970_29275  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
CP970_32705  twin-arginine translocation signal domain-containing protein [KO:K01119] [EC:3.1.4.16 3.1.3.6]
CP970_17250  adenylate kinase [KO:K00939] [EC:2.7.4.3]
CP970_31535  phosphodiesterase [KO:K03651] [EC:3.1.4.53]
CP970_36190  HIT domain-containing protein [KO:K19710] [EC:2.7.7.53]
CP970_09290  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
CP970_09300  sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
CP970_09295  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
CP970_08370  pucL; urate oxidase [KO:K00365] [EC:1.7.3.3]
CP970_08375  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
CP970_08380  uraD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
CP970_16440  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
CP970_07910  allB; allantoinase AllB [KO:K01466] [EC:3.5.2.5]
CP970_07905  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
CP970_41040  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
CP970_06445  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
CP970_12605  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
CP970_41035  urease subunit beta [KO:K01429] [EC:3.5.1.5]
CP970_41030  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
CP970_06450  ureA; urease subunit gamma [KO:K14048] [EC:3.5.1.5]
CP970_12610  ureA; urease subunit gamma [KO:K14048] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ska00030  Pentose phosphate pathway
ska00220  Arginine biosynthesis
ska00250  Alanine, aspartate and glutamate metabolism
ska00260  Glycine, serine and threonine metabolism
ska00340  Histidine metabolism
ska00630  Glyoxylate and dicarboxylate metabolism
ska00730  Thiamine metabolism
ska00740  Riboflavin metabolism
ska00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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