KEGG   PATHWAY: slc00230
Entry
slc00230                    Pathway                                
Name
Purine metabolism - Streptomyces lydicus 103
Class
Metabolism; Nucleotide metabolism
Pathway map
slc00230  Purine metabolism
slc00230

Module
slc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:slc00230]
slc_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:slc00230]
slc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:slc00230]
slc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:slc00230]
slc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:slc00230]
slc_M00546  Purine degradation, xanthine => urea [PATH:slc00230]
slc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:slc00230]
slc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:slc00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces lydicus 103 [GN:slc]
Gene
SL103_03670  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
SL103_01255  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
SL103_01175  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
SL103_31650  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
SL103_01245  phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
SL103_01235  phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
SL103_01240  phosphoribosylformylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
SL103_01260  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
SL103_04065  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
SL103_04070  5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
SL103_01190  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
SL103_20910  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
SL103_31645  bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
SL103_11965  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
SL103_11675  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
SL103_32630  bifunctional metallophosphatase/5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
SL103_05100  HAD family hydrolase [KO:K02566] [EC:3.1.3.5]
SL103_31115  purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
SL103_08870  laccase [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
SL103_21850  rihB; ribonucleoside hydrolase [KO:K25589] [EC:3.2.2.2 3.2.2.3]
SL103_33405  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
SL103_02530  IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
SL103_02535  inosine 5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
SL103_06040  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
SL103_04810  non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [KO:K01519] [EC:3.6.1.66]
SL103_22185  oxidoreductase [KO:K11177] [EC:1.17.1.4]
SL103_25600  xanthine dehydrogenase [KO:K11177] [EC:1.17.1.4]
SL103_22190  molybdopterin dehydrogenase [KO:K11178] [EC:1.17.1.4]
SL103_25605  molybdopterin dehydrogenase [KO:K11178] [EC:1.17.1.4]
SL103_22195  (2Fe-2S)-binding protein [KO:K13483]
SL103_25610  (2Fe-2S)-binding protein [KO:K13483]
SL103_31815  glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
SL103_12235  inosine 5-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
SL103_13040  tRNA-specific adenosine deaminase [KO:K01487] [EC:3.5.4.3]
SL103_12140  guanylate kinase [KO:K00942] [EC:2.7.4.8]
SL103_27110  ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [KO:K00525] [EC:1.17.4.1]
SL103_29680  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
SL103_29685  ribonucleoside-diphosphate reductase [KO:K00526] [EC:1.17.4.1]
SL103_06760  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
SL103_28640  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
SL103_27165  kinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
SL103_11970  GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
SL103_03815  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SL103_33145  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SL103_31025  adenylate cyclase [KO:K01768] [EC:4.6.1.1]
SL103_02985  hypothetical protein [KO:K05873] [EC:4.6.1.1]
SL103_01135  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
SL103_08500  ribokinase [KO:K00856] [EC:2.7.1.20]
SL103_02120  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
SL103_31195  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
SL103_06750  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
SL103_09255  bifunctional metallophosphatase/5'-nucleotidase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
SL103_02315  adenylate kinase [KO:K00939] [EC:2.7.4.3]
SL103_11875  HIT family hydrolase [KO:K19710] [EC:2.7.7.53]
SL103_25780  adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
SL103_25790  sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
SL103_25785  sulfate adenylyltransferase small subunit [KO:K00957] [EC:2.7.7.4]
SL103_25185  urate oxidase [KO:K00365] [EC:1.7.3.3]
SL103_25190  hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
SL103_25195  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
SL103_31360  OHCU decarboxylase [KO:K16840] [EC:4.1.1.97]
SL103_25120  Asp/Glu/hydantoin racemase [KO:K16841] [EC:5.1.99.3]
SL103_25110  allantoinase [KO:K01466] [EC:3.5.2.5]
SL103_05880  allantoicase [KO:K01477] [EC:3.5.3.4]
SL103_25105  allantoicase [KO:K01477] [EC:3.5.3.4]
SL103_20715  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
SL103_28230  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
SL103_20720  urease subunit beta [KO:K01429] [EC:3.5.1.5]
SL103_20725  urease subunit gamma [KO:K01430] [EC:3.5.1.5]
SL103_28235  urease subunit gamma [KO:K14048] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
slc00030  Pentose phosphate pathway
slc00220  Arginine biosynthesis
slc00250  Alanine, aspartate and glutamate metabolism
slc00260  Glycine, serine and threonine metabolism
slc00340  Histidine metabolism
slc00630  Glyoxylate and dicarboxylate metabolism
slc00730  Thiamine metabolism
slc00740  Riboflavin metabolism
slc00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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