KEGG   PATHWAY: spis00480
Entry
spis00480                   Pathway                                
Name
Glutathione metabolism - Stylophora pistillata (Smooth Cauliflower Coral)
Class
Metabolism; Metabolism of other amino acids
Pathway map
spis00480  Glutathione metabolism
spis00480

Module
spis_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:spis00480]
Other DBs
GO: 0006749
Organism
Stylophora pistillata (Smooth Cauliflower Coral) [GN:spis]
Gene
111326037  uncharacterized protein LOC111326037 isoform X1 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
111334198  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111332378  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111332385  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111332387  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111332391  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111336881  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111324296  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111346304  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111338839  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
111333813  uncharacterized protein LOC111333813 [KO:K00682] [EC:4.3.2.9]
111320963  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
111326023  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
111336996  5-oxoprolinase-like isoform X1 [KO:K01469] [EC:3.5.2.9]
111337026  5-oxoprolinase-like isoform X1 [KO:K01469] [EC:3.5.2.9]
111330314  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
111330338  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
111333879  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
111327092  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
111342558  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
111326884  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
111329531  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
111326321  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
111324386  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
111336787  endoplasmic reticulum aminopeptidase 1-like [KO:K11140] [EC:3.4.11.2]
111334297  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
111326593  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111326594  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111324781  glutathione S-transferase U20-like [KO:K00799] [EC:2.5.1.18]
111324782  glutathione S-transferase U20-like [KO:K00799] [EC:2.5.1.18]
111322205  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
111335414  uncharacterized protein LOC111335414 [KO:K00799] [EC:2.5.1.18]
111325099  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111325129  glutathione S-transferase Y1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111323991  glutathione S-transferase-like [KO:K23790] [EC:2.5.1.18]
111344845  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
111342431  uncharacterized protein LOC111342431 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111342434  probable glutathione S-transferase 5 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111342436  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111342437  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111342438  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111342441  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111342430  uncharacterized protein LOC111342430 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111337850  N-acetyltransferase 8-like [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111346407  N-acetyltransferase 8-like [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111333733  probable N-acetyltransferase CML2 isoform X1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111333875  probable N-acetyltransferase CML1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111333876  probable N-acetyltransferase CML1 isoform X1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111333883  probable N-acetyltransferase CML1 isoform X1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111333889  probable N-acetyltransferase CML1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111333899  probable N-acetyltransferase CML1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
111339105  LOW QUALITY PROTEIN: glutathione reductase, mitochondrial-like [KO:K00383] [EC:1.8.1.7]
111338535  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
111324807  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
111329391  6-phosphogluconate dehydrogenase, decarboxylating-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111340210  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111343278  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
111325528  glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
111325994  epididymal secretory glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
111331605  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
111343967  epididymal secretory glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
111344236  glutathione peroxidase 1-like isoform X1 [KO:K00432] [EC:1.11.1.9]
111333917  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
111333928  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
111334658  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
111325771  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
111334447  spermine synthase-like isoform X1 [KO:K00802] [EC:2.5.1.22]
111334508  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
111322739  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
111341578  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
111336795  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
111326489  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
spis00220  Arginine biosynthesis
spis00250  Alanine, aspartate and glutamate metabolism
spis00270  Cysteine and methionine metabolism
spis00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
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