KEGG   PATHWAY: spis04142
Entry
spis04142                   Pathway                                
Name
Lysosome - Stylophora pistillata (Smooth Cauliflower Coral)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
spis04142  Lysosome
spis04142

Other DBs
GO: 0005764
Organism
Stylophora pistillata (Smooth Cauliflower Coral) [GN:spis]
Gene
111332353  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
111333729  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
111336259  V-type proton ATPase subunit d 1-like [KO:K02146]
111341430  V-type proton ATPase subunit H-like [KO:K02144]
111328001  V-type proton ATPase subunit S1-like [KO:K03662]
111324156  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
111323094  V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]
111345733  LOW QUALITY PROTEIN: dmX-like protein 2 [KO:K24155]
111340260  WD repeat-containing protein 7-like isoform X1 [KO:K24738]
111340232  cathepsin B-like cysteine proteinase 4 [KO:K01363] [EC:3.4.22.1]
111333695  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
111344749  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
111344752  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
111322973  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
111337055  cathepsin L-like [KO:K01373] [EC:3.4.22.41]
111336919  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111336926  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111322212  cathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
111344129  cathepsin L-like [KO:K01365] [EC:3.4.22.15]
111329960  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
111342829  legumain-like [KO:K01369] [EC:3.4.22.34]
111338468  tripeptidyl-peptidase 1-like [KO:K01279] [EC:3.4.14.9]
111336425  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
111336128  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
111325349  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
111325383  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
111321885  alpha-L-iduronidase-like [KO:K01217] [EC:3.2.1.76]
111321754  uncharacterized protein LOC111321754 [KO:K01204] [EC:3.2.1.49]
111340747  LOW QUALITY PROTEIN: alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
111340767  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
111339083  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
111339084  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
111345370  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
111345779  uncharacterized protein LOC111345779 [KO:K01206] [EC:3.2.1.51]
111324731  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
111323937  LOW QUALITY PROTEIN: alpha-L-fucosidase 1-like [KO:K01206] [EC:3.2.1.51]
111336383  uncharacterized protein LOC111336383 [KO:K12373] [EC:3.2.1.52]
111336384  uncharacterized protein LOC111336384 [KO:K12373] [EC:3.2.1.52]
111336390  uncharacterized protein LOC111336390 [KO:K12373] [EC:3.2.1.52]
111336392  uncharacterized protein LOC111336392 isoform X1 [KO:K12373] [EC:3.2.1.52]
111331719  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
111331721  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
111335655  beta-hexosaminidase 1-like [KO:K12373] [EC:3.2.1.52]
111343887  beta-mannosidase-like isoform X1 [KO:K01192] [EC:3.2.1.25]
111329016  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
111322339  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
111329380  uncharacterized protein LOC111329380 [KO:K01197] [EC:3.2.1.35]
111326369  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
111318943  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
111333997  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
111321416  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
111342241  arylsulfatase J-like [KO:K01135] [EC:3.1.6.12]
111320759  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
111338690  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
111331497  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
111322000  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
111342786  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
111322101  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
111333830  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
111325693  N-acetylgalactosamine-6-sulfatase-like [KO:K01132] [EC:3.1.6.4]
111338464  N-acetylglucosamine-6-sulfatase-like isoform X1 [KO:K01137] [EC:3.1.6.14]
111326384  iduronate 2-sulfatase-like isoform X1 [KO:K01136] [EC:3.1.6.13]
111338001  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
111327167  N-sulphoglucosamine sulphohydrolase-like isoform X1 [KO:K01565] [EC:3.10.1.1]
111321971  lipase member K-like [KO:K01052] [EC:3.1.1.13]
111340872  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
111323811  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
111323812  lipase member K-like [KO:K01052] [EC:3.1.1.13]
111340194  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
111327798  group XV phospholipase A2-like isoform X1 [KO:K06129] [EC:3.1.1.5]
111335819  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
111322022  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
111338614  testicular acid phosphatase homolog [KO:K14410] [EC:3.1.3.2]
111339961  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
111321260  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
111341376  tartrate-resistant acid phosphatase type 5-like isoform X1 [KO:K14379] [EC:3.1.3.2]
111324559  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
111334444  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
111334445  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
111326091  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]
111339694  uncharacterized protein LOC111339694 isoform X1 [KO:K01444] [EC:3.5.1.26]
111342381  prosaposin-like isoform X1 [KO:K12382]
111337315  ganglioside GM2 activator-like [KO:K12383]
111325151  lysosomal thioesterase PPT2-A-like [KO:K01074] [EC:3.1.2.22]
111327696  palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
111331091  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
111331102  lysosome-associated membrane glycoprotein 1-like isoform X1 [KO:K06528]
111334404  CD63 antigen-like [KO:K06497]
111321825  lysosome membrane protein 2-like [KO:K12384]
111337343  lysosome membrane protein 2-like [KO:K12384]
111337350  lysosome membrane protein 2-like [KO:K12384]
111346112  lysosome membrane protein 2-like [KO:K12384]
111342143  Niemann-Pick C1 protein-like [KO:K12385]
111341522  patched domain-containing protein 3-like [KO:K12385]
111323087  Niemann-Pick C1-like protein 1 [KO:K12385]
111327323  ecdysteroid-regulated 16 kDa protein-like [KO:K13443]
111329767  epididymal secretory protein E1-like [KO:K13443]
111337547  cystinosin homolog [KO:K12386]
111337838  cystinosin-like [KO:K12386]
111324817  sialin-like [KO:K12301]
111334390  sialin-like [KO:K12301]
111326100  lysosomal-associated transmembrane protein 4A-like [KO:K12387]
111327852  ATP-binding cassette sub-family A member 2-like [KO:K05642]
111321135  ATP-binding cassette sub-family B member 9-like [KO:K05656]
111323866  sialomucin core protein 24-like [KO:K06546]
111319244  ectonucleoside triphosphate diphosphohydrolase 4-like [KO:K12305] [EC:3.6.1.6]
111327728  ectonucleoside triphosphate diphosphohydrolase 4-like [KO:K12305] [EC:3.6.1.6]
111324592  sortilin-like [KO:K12388]
111321741  protein btn-1-like [KO:K12389]
111342293  protein BTN1-like [KO:K12389]
111335813  protein btn1-like [KO:K12389]
111344190  battenin-like [KO:K12389]
111342302  protein BTN1-like [KO:K12389]
111346963  protein BTN1-like [KO:K12389]
111345000  battenin-like [KO:K12389]
111322922  protein BTN1-like [KO:K12389]
111322924  protein BTN1-like [KO:K12389]
111335635  battenin-like [KO:K12389]
111321963  protein BTN1-like [KO:K12389]
111331488  protein BTN1-like [KO:K12389]
111333564  protein BTN1-like [KO:K12389]
111322920  protein BTN1-like [KO:K12389]
111322937  protein BTN1-like [KO:K12389]
111339323  uncharacterized protein LOC111339323 [KO:K12307]
111324491  uncharacterized protein LOC111324491 [KO:K12307]
111332767  heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]
111332777  heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]
111337648  sulfatase-modifying factor 1-like isoform X1 [KO:K13444] [EC:1.8.3.7]
111319225  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like [KO:K08239] [EC:2.7.8.17]
111337779  N-acetylglucosamine-1-phosphotransferase subunit gamma-like isoform X1 [KO:K10087]
111321003  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]
111329920  cation-independent mannose-6-phosphate receptor-like [KO:K06564]
111329930  cation-independent mannose-6-phosphate receptor-like [KO:K06564]
111345505  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
111342637  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
111332967  uncharacterized protein LOC111332967 [KO:K10089]
111330049  clathrin light chain B-like [KO:K04644]
111338753  clathrin heavy chain 1-like [KO:K04646]
111341730  AP-1 complex subunit gamma-1-like isoform X1 [KO:K12391]
111322097  AP-1 complex subunit beta-1-like [KO:K12392]
111335418  AP-1 complex subunit mu-1-like [KO:K12393]
111330486  AP-1 complex subunit sigma-2-like isoform X1 [KO:K12394]
111336685  AP-3 complex subunit delta-1-like [KO:K12396]
111324908  AP-3 complex subunit beta-2-like [KO:K12397]
111323623  AP-3 complex subunit mu-1-like [KO:K12398]
111324663  AP-3 complex subunit sigma-1-like [KO:K12399]
111333680  AP-4 complex subunit epsilon-like [KO:K12400]
111335820  AP-4 complex subunit beta-1-like [KO:K12401]
111344125  AP-4 complex subunit mu-like [KO:K12402]
111339039  AP-4 complex subunit sigma-1-like [KO:K12403]
111343184  ADP-ribosylation factor-binding protein GGA2-like [KO:K12404]
111330218  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
111323454  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
111325786  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
111333493  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
111322139  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
111336780  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
spis00511  Other glycan degradation
spis00531  Glycosaminoglycan degradation
spis04130  SNARE interactions in vesicular transport
spis04140  Autophagy - animal
spis04144  Endocytosis
KO pathway
ko04142   
LinkDB

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