KEGG ORTHOLOGY: K12401

ORTHOLOGY: K12401

Entry

K12401                      KO

Symbol

AP4B1

Name

AP-4 complex subunit beta-1

Pathway

map04142

Lysosome biogenesis

Disease

H00266

Hereditary spastic paraplegia

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome biogenesis
    K12401  AP4B1; AP-4 complex subunit beta-1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12401  AP4B1; AP-4 complex subunit beta-1
Membrane trafficking [BR:ko04131]
Endosome - Golgi transport
  Others
   AP-4 complex
    K12401  AP4B1; AP-4 complex subunit beta-1

Other DBs

TC:	9.B.278.1.5

Genes

HSA:	10717(AP4B1)

PTR:	457138(AP4B1)

PPS:	100975695(AP4B1)

GGO:	101137631(AP4B1)

PON:	100447996(AP4B1)

PPYG:

129019903(AP4B1)

NLE:	100585947(AP4B1)

HMH:	116469579(AP4B1)

SSYN:

134734177(AP4B1)

MCC:	707634(AP4B1)

MCF:	101925391(AP4B1)

MTHB:

126930612

MNI:	105479162(AP4B1)

CSAB:

103224181(AP4B1)

CATY:

105596355(AP4B1)

PANU:

101017300(AP4B1)

TGE:	112610745(AP4B1)

MLEU:

105554344(AP4B1)

RRO:	104669090(AP4B1)

RBB:	108528111(AP4B1)

TFN:	117075759(AP4B1)

PTEH:

111549623(AP4B1)

CANG:

105505326(AP4B1)

CJC:	100410952(AP4B1)

SBQ:	101030970(AP4B1)

CIMI:

108301178(AP4B1)

ANAN:

105726994(AP4B1)

CSYR:

103260727(AP4B1)

MMUR:

105878723(AP4B1)

LCAT:

123635068(AP4B1)

ERUF:

138390884(AP4B1)

PCOQ:

105810604(AP4B1)

OGA:	100953160(AP4B1)

MMU:	67489(Ap4b1)

MCAL:

110291447(Ap4b1)

MPAH:

110319915(Ap4b1)

RNO:	310746(Ap4b1)

MCOC:

116093539(Ap4b1)

ANU:	117707074(Ap4b1)

ASYL:

127682877(Ap4b1)

MUN:	110546993(Ap4b1)

CGE:	100759820(Ap4b1)

MAUA:

101834291(Ap4b1)

PROB:

127232621(Ap4b1)

PLEU:

114684766(Ap4b1)

PMAV:

102906821(Ap4b1)

MORG:

121437924(Ap4b1)

MFOT:

126510786

AAMP:

119801285(Ap4b1)

CNL:	130890074(Ap4b1)

NGI:	103734928(Ap4b1)

HGL:	101714886(Ap4b1)

CPOC:

100718272(Ap4b1)

CCAN:

109688090(Ap4b1)

DORD:

105991882(Ap4b1)

DSP:	122118318(Ap4b1)

DMER:

138803084 138816557(Ap4b1)

PLOP:

125355441(Ap4b1)

NCAR:

124993852

MMMA:

107156169(Ap4b1)

ITI:	101969718(Ap4b1)

OCU:

100346470

OPI:	101532439(AP4B1)

OCZ:	121168853(AP4B1)

TUP:	102489753(AP4B1)

GVR:	103591911(AP4B1)

CFA:	483125(AP4B1)

CLUD:

112664180(AP4B1)

VVP:	112916757(AP4B1)

VLG:	121491409(AP4B1)

NPO:	129501315(AP4B1)

AML:	100479658(AP4B1)

UMR:	103669431(AP4B1)

UAH:	113244402(AP4B1)

UAR:	123795046(AP4B1)

ELK:

111142873

LLV:

125097099

MPUF:

101676166(AP4B1)

MNP:	132001325(AP4B1)

MLK:	131809026(AP4B1)

NVS:	122900350(AP4B1)

ORO:	101366783(AP4B1)

EJU:	114207855(AP4B1)

ZCA:	113929394(AP4B1)

MLX:	118000506(AP4B1)

MANO:

123859241(AP4B1)

NSU:	110580329(AP4B1)

LWW:	102749612(AP4B1)

FCA:	101100653(AP4B1)

PYU:	121027720(AP4B1)

PCOO:

112871805(AP4B1)

PBG:	122480964(AP4B1)

PVIV:

125173588(AP4B1)

LRUF:

124515017

LGF:	123598482(AP4B1)

AJU:

106969607

PTG:	102956814(AP4B1)

PPAD:

109272084(AP4B1)

PUC:

125912227

PLEZ:

122228441(AP4B1)

HHV:	120243074(AP4B1)

CCRU:

144233830(AP4B1)

BTA:	512078(AP4B1)

BOM:	102266605(AP4B1)

BIU:	109555903(AP4B1)

BJV:	133243895(AP4B1)

BBUB:

102404676(AP4B1)

BKE:	129654918(AP4B1)

BBIS:

104981591(AP4B1)

CHX:	102168679(AP4B1)

OAS:	101120710(AP4B1)

OCAN:

138446310(AP4B1)

BTAX:

128044419(AP4B1)

CSUM:

138073045(AP4B1)

ODA:	120856052(AP4B1)

CCAD:

122436082(AP4B1)

MREE:

136147327(AP4B1)

OVR:	110146924(AP4B1)

MBEZ:

129541006(AP4B1)

SSC:	100516855(AP4B1)

CFR:	102506787(AP4B1)

CBAI:

105079649(AP4B1)

CDK:	105085860(AP4B1)

VPC:	102530564(AP4B1)

BACU:

103007608(AP4B1)

BMUS:

118901366(AP4B1)

LVE:	103088041(AP4B1)

OOR:	101271397(AP4B1)

LALB:

132514496(AP4B1)

GMF:	115859769(AP4B1)

DDP:	132435384(AP4B1)

DLE:	111180006(AP4B1)

PCAD:

102988695(AP4B1)

PSIU:

116762064(AP4B1)

PPHC:

136126517(AP4B1)

NASI:

112413043(AP4B1)

ECB:	100059318(AP4B1)

EPZ:	103565932(AP4B1)

EAI:	106828573(AP4B1)

MYB:	102250781(AP4B1)

MYD:	102758260(AP4B1)

MMYO:

118672695(AP4B1)

MLF:	102434826(AP4B1)

MDT:	132220890(AP4B1)

MYUM:

138996067(AP4B1)

PKL:	118727245(AP4B1)

EFUS:

103291204(AP4B1)

MNA:	107545356(AP4B1)

DRO:	112313788(AP4B1)

SHON:

118981886(AP4B1)

AJM:	119054519(AP4B1)

PDIC:

114489049(AP4B1)

PHAS:

123804491(AP4B1)

MMF:	118637035(AP4B1)

PPAM:

129063698(AP4B1)

HAI:	109391561(AP4B1)

RFQ:	117014548(AP4B1)

PALE:

102883757(AP4B1)

PGIG:

120585052(AP4B1)

PVP:	105297980(AP4B1)

RAY:	107499837(AP4B1)

MJV:	108390135(AP4B1)

TOD:	119236047(AP4B1)

SARA:

101538748(AP4B1)

SFUM:

130046164(AP4B1)

SETR:

125997252(AP4B1)

LAV:	100657433(AP4B1)

TMU:

101346665

ETF:	101649047(AP4B1)

DNM:	101414683(AP4B1) 105746411

MDO:	100030690(AP4B1)

GAS:	123247188(AP4B1)

SHR:	100921355(AP4B1)

AFZ:

127559295

PCW:	110219043(AP4B1)

TVP:	118858576(AP4B1)

PBRV:

138162838(AP4B1)

MLAO:

141488421(AP4B1)

OAA:	100074937(AP4B1)

TACU:

119930581(AP4B1)

GGA:	419879(AP4B1)

PCOC:

116236951(AP4B1)

MGP:	100539997(AP4B1)

CJO:	107324829(AP4B1)

TPAI:

128088042(AP4B1)

LMUT:

125684202(AP4B1)

NMEL:

110388117(AP4B1)

APLA:

101796667(AP4B1)

AACU:

137843938(AP4B1)

OJA:	118178407(AP4B1)

ACYG:

106041328(AP4B1)

CATA:

118255254(AP4B1)

AFUL:

116498887(AP4B1)

TGU:	100218221(AP4B1)

LSR:	110473471(AP4B1)

VMC:	128818572(AP4B1)

VCHA:

128799440(AP4B1)

AIB:	137462580(AP4B1)

SCAN:

103823336(AP4B1)

PMOA:

120495890(AP4B1)

OTC:	121348003(AP4B1)

PRUF:

121353656(AP4B1)

ATRC:

139601370(AP4B1)

MATE:

118696401(AP4B1)

MAEN:

136566135(AP4B1)

GFR:	102044993(AP4B1)

FAB:	101819197(AP4B1)

OMA:	130263703(AP4B1)

PHI:	102108416(AP4B1)

PMAJ:

107214981(AP4B1)

CCAE:

111939601(AP4B1)

CCW:	104692404(AP4B1)

CBRC:

103625284(AP4B1)

ACOE:

138098767(AP4B1)

ETL:	114064395(AP4B1)

ZAB:	102068166(AP4B1)

ZLE:	135458044(AP4B1)

ACHL:

103810077(AP4B1)

SVG:	106851055(AP4B1)

MMEA:

130584313(AP4B1)

HRT:	120762718(AP4B1)

SATI:

136371624(AP4B1)

CFAI:

136301261(AP4B1)

CCIC:

134054218(AP4B1)

NNT:	104413466(AP4B1)

SHAB:

115602448(AP4B1)

POCC:

134167701(AP4B1)

FPG:	101922637(AP4B1)

FCH:	102056403(AP4B1)

FRS:	119158457(AP4B1)

CCRI:

104168153(AP4B1)

ACUN:

113488887(AP4B1)

ANOC:

141969476(AP4B1)

SURA:

141954480(AP4B1)

TALA:

104357476(AP4B1)

ACHC:

115335092(AP4B1)

HALD:

104322127(AP4B1)

HLE:	104838752(AP4B1)

AGEN:

126052073

HHAR:

128154384(AP4B1)

BBUT:

142043498(AP4B1)

GCL:

127026143

CSTI:

104557368(AP4B1)

LDI:	104347877(AP4B1)

MNB:	103778995(AP4B1)

DPUB:

104296311(AP4B1)

PPUS:

135191575(AP4B1)

IIN:	128978202(AP4B1)

AVIT:

104269447(AP4B1)

BRHI:

104499439(AP4B1)

EGZ:	104126783(AP4B1)

NNI:	104010327(AP4B1)

PCRI:

104038537(AP4B1)

PCAO:

104048538(AP4B1)

PARX:

142067134(AP4B1)

PADL:

103923549(AP4B1)

AFOR:

103893557(AP4B1)

CBOR:

142093258(AP4B1)

GSTE:

104261133(AP4B1)

CBOY:

140662710(AP4B1)

MAME:

142419230(AP4B1)

CLV:	102084117(AP4B1)

CNIC:

135997216(AP4B1)

MUI:	104541212(AP4B1)

PGUU:

104460280(AP4B1)

PLET:

104619354(AP4B1)

EHS:	104507036(AP4B1)

CMAC:

104475119(AP4B1)

CUCA:

104067095(AP4B1)

PCUR:

138730553(AP4B1)

TEO:	104384512(AP4B1)

BREG:

104638912(AP4B1)

GAME:

129196385(AP4B1)

OHA:	104333537(AP4B1)

ACAR:

104524090(AP4B1)

CPEA:

104392509(AP4B1)

CVF:	104289494(AP4B1)

RTD:	128900172(AP4B1)

CRID:

134525639(AP4B1)

LMIC:

141733539(AP4B1)

NARQ:

141475058(AP4B1)

AAM:	106485276(AP4B1)

AROW:

112971652(AP4B1)

NPD:	112951495(AP4B1)

TGT:	104569817(AP4B1)

DNE:	112990217(AP4B1)

SCAM:

104142371(AP4B1)

ASN:	102382993(AP4B1)

AMJ:	102574254(AP4B1)

CPOO:

109317856(AP4B1)

GGN:	109295101(AP4B1)

PSS:	102444599(AP4B1)

CIZ:	142001951(AP4B1)

CMY:	102931455(AP4B1)

CCAY:

125624944(AP4B1)

LKP:	140901217(AP4B1)

NDS:	141975462(AP4B1)

DCC:	119846416(AP4B1)

CPIC:

101945467(AP4B1)

TST:	117877481(AP4B1)

EOB:	135877539(AP4B1)

CABI:

116816942(AP4B1)

MRV:	120404201(AP4B1)

EMQ:	137160276(AP4B1)

ACS:	100556513(ap4b1)

ASAO:

132773350(AP4B1)

PVT:	110072329(AP4B1)

SUND:

121928348(AP4B1)

PBI:	103065649(AP4B1)

PMUR:

107299884(AP4B1)

CTIG:

120298217 120316649(AP4B1)

TSR:	106539293(AP4B1) 106540535

PGUT:

117663798(AP4B1)

PCAE:

139314271(AP4B1)

APRI:

131195434(AP4B1)

PTEX:

113444279(AP4B1)

NSS:	113416985(AP4B1)

VKO:	123031985(AP4B1)

PMUA:

114599386(AP4B1)

PRAF:

128416197(AP4B1)

ZVI:	118089015(AP4B1)

HCG:	128323762(AP4B1)

GJA:	107110639(AP4B1)

STOW:

125433753(AP4B1)

EMC:	129330734(AP4B1)

XLA:	108708166(ap4b1.L)

XTR:	100495149(ap4b1)

NPR:	108798090(AP4B1)

RTEM:

120927036(AP4B1)

ACAT:

141128421(AP4B1)

PADS:

140340666(AP4B1)

BBUF:

120994984(AP4B1)

BGAR:

122930249(AP4B1)

DTC:	141099048(AP4B1)

PWL:	138299970(AP4B1)

MUO:	115481800(AP4B1)

GSH:	117347238(AP4B1)

DRE:	393309(ap4b1)

DAES:

130217535(ap4b1)

SRX:

107746335

SANH:

107672998 107697033

SGH:	107554218(ap4b1) 107566065

CCAR:

109099347

CAUA:

113041005 113094048

CGIB:

127945172 128011533

PTET:

122328601(ap4b1)

LROH:

127154728(ap4b1)

GRF:	141291504(ap4b1)

OMC:	131532653(ap4b1)

PPRM:

120473930 120473935(ap4b1)

RKG:	130084372(ap4b1)

MAMB:

125259960(ap4b1)

CIDE:

127504711

CERY:

137009564(ap4b1)

MASI:

127418895

TROS:

130571761(ap4b1)

TDW:	130409294(ap4b1)

MANU:

129430432(ap4b1)

PDAB:

135775861(ap4b1)

IPU:

108275768

IFU:	128618926(ap4b1)

PHYP:

113545519(ap4b1)

SMEO:

124399239(ap4b1)

TFD:	113650711(ap4b1)

TVC:	132862090(ap4b1)

CGAR:

128510890(ap4b1)

NGRA:

132897176(ap4b1)

TRN:	134333330(ap4b1)

AMEX:

103037901(ap4b1)

CMAO:

118822155(ap4b1)

EEE:	113587800(ap4b1)

CHAR:

105906440(ap4b1)

SPIL:

134087799(ap4b1)

ASAD:

121712750(ap4b1)

TRU:	101069023(ap4b1)

TFS:	130529438(ap4b1)

TNG:	GSTEN00012386G001

TBEN:

117491154(ap4b1)

CGOB:

115010594(ap4b1)

PGEO:

117449490(ap4b1)

GACU:

117541490(ap4b1)

EMAC:

134871403(ap4b1)

ELY:	117257930(ap4b1)

EFO:	125891330(ap4b1)

PLEP:

121946528(ap4b1)

SLUC:

116057988(ap4b1)

ECRA:

117948230(ap4b1)

ESP:	116692985(ap4b1)

PFLV:

114559244(ap4b1)

GAT:	120829199(ap4b1)

PPUG:

119223195(ap4b1)

AFB:	129099806(ap4b1)

CLUM:

117733545(ap4b1)

PSWI:

130199133(ap4b1)

CANA:

137800444(ap4b1)

CVE:	137889463(ap4b1)

MSAM:

119905769 119919382

SCHU:

122883044(ap4b1)

EARM:

139288891(ap4b1)

CUD:	121517886(ap4b1)

SPUL:

138589463(ap4b1)

LMIX:

132990389(ap4b1)

HTC:	141799786(ap4b1)

ALAT:

119022129(ap4b1)

ASTR:

137610548(ap4b1)

PKLU:

139210364(ap4b1)

LCO:	104933749(ap4b1)

ONL:	100704202(ap4b1)

OAU:	116325154(ap4b1)

OLA:	101162210(ap4b1)

OML:	112158680(ap4b1)

CSAI:

133456875(ap4b1)

XMA:	102218456(ap4b1)

XCO:	114148151(ap4b1)

XHE:	116724191(ap4b1)

PRET:

103467066(ap4b1)

PFOR:

103150231(ap4b1)

PLAI:

106955717(ap4b1)

PMEI:

106932583

GAF:	122836735(ap4b1)

PPRL:

129371689(ap4b1)

CVG:	107093791(ap4b1)

CTUL:

119775466(ap4b1)

GMU:	124875191(ap4b1)

NFU:	107391542(ap4b1)

KMR:	108249174(ap4b1)

ALIM:

106523020(ap4b1)

NWH:	119417344(ap4b1)

LTU:	140272116(ap4b1)

MCEP:

124997347(ap4b1)

AOCE:

111582016(ap4b1)

EJA:	138210220(ap4b1)

BFRE:

138626657(ap4b1)

LCF:

108899619

CSEM:

103384715(ap4b1)

POV:	109630488(ap4b1)

SSEN:

122776932(ap4b1)

SSOE:

131468467(ap4b1)

HHIP:

117765387(ap4b1)

HSP:	118110942(ap4b1)

PPLT:

128442950(ap4b1)

SMAU:

118316600(ap4b1)

SDU:	111236977(ap4b1)

SLAL:

111659930(ap4b1)

XGL:	120803651(ap4b1)

HCQ:	109528588(ap4b1)

SSCV:

125987856(ap4b1)

SBIA:

133512313(ap4b1)

PEE:	133408707(ap4b1)

PTAO:

133487091(ap4b1)

BPEC:

110162117(ap4b1)

ENY:	140363574(ap4b1)

MALB:

109969968(ap4b1)

BSPL:

114858889(ap4b1)

SJO:	128357193(ap4b1)

SSCO:

133987581(ap4b1)

TTY:	137183992(ap4b1)

GMH:	115548264(ap4b1)

SASA:

106572995(ap4b1)

STRU:

115166442(ap4b1)

OTW:	112236629(ap4b1)

OMY:	110512846(ap4b1)

OGO:	124018239(ap4b1)

OKI:	109881209(ap4b1)

OKE:	118377996 127927930

OMM:	135503827(ap4b1)

OCLA:

139403194 139417449

SFON:

129829427(ap4b1)

CCLU:

121587363(ap4b1)

ELS:	105030751(ap4b1)

OEP:	134019454(ap4b1)

SFM:	108928189(ap4b1)

PKI:	111855214(ap4b1)

AANG:

118207629(ap4b1)

AROT:

135234977(ap4b1)

CCOG:

133139022(ap4b1)

LOC:	102684786(ap4b1)

PSPA:

121299439 121299721

ARUT:

117426958 117965957

PSEX:

120526269(ap4b1)

LCM:	102345448(AP4B1)

CMK:	103179049(ap4b1)

RTP:	109915658(ap4b1)

CPLA:

122563287(ap4b1)

CPUN:

140467187(ap4b1)

HOC:	132828228(ap4b1)

SCAU:

119978417(ap4b1)

LERI:

129708604(ap4b1)

HAKA:

140731998(ap4b1)

PMRN:

116942483(AP4B1)

LRJ:	133349353(AP4B1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

FOC:

TPAL:

ZNE:

CSEC:

PAME:

IEL:

HAMR:

EAF:

LSM:

TCF:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

SPRM:

ESN:

MNZ:

MRJ:

PORN:

OOT:

HAZT:

DSV:

DALB:

RMP:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_194538

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

HMG:

RES:

TAD:	TRIADDRAFT_22316

AQU:

100637445

TOT:	TOT_010000784

» show all

Reference

PMID:10066790

Authors

Dell'Angelica EC, Mullins C, Bonifacino JS

Title

AP-4, a novel protein complex related to clathrin adaptors.

Journal

J Biol Chem 274:7278-85 (1999)
DOI:10.1074/jbc.274.11.7278

Sequence

[hsa:10717] [mmu:67489]

LinkDB

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