KEGG   PATHWAY: ssck00260
Entry
ssck00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Sporothrix schenckii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ssck00260  Glycine, serine and threonine metabolism
ssck00260

Module
ssck_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ssck00260]
ssck_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ssck00260]
ssck_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ssck00260]
ssck_M00621  Glycine cleavage system [PATH:ssck00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sporothrix schenckii [GN:ssck]
Gene
SPSK_05071  aspartate kinase [KO:K00928] [EC:2.7.2.4]
SPSK_01158  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SPSK_03400  hypothetical protein [KO:K00003] [EC:1.1.1.3]
SPSK_09398  hypothetical protein [KO:K00872] [EC:2.7.1.39]
SPSK_02376  threonineeeee synthase [KO:K01733] [EC:4.2.3.1]
SPSK_03403  threonineeeee aldolase [KO:K01620] [EC:4.1.2.48]
SPSK_00503  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SPSK_08885  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SPSK_01601  alanine-glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SPSK_00457  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SPSK_01867  Uridine/cytidine kinase [KO:K15918] [EC:2.7.1.31]
SPSK_08843  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SPSK_05156  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SPSK_02512  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SPSK_03275  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SPSK_01771  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SPSK_06521  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SPSK_02321  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
SPSK_07297  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
SPSK_00724  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
SPSK_07167  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
SPSK_03130  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
SPSK_00016  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
SPSK_02189  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SPSK_00803  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SPSK_00489  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SPSK_08007  glycine cleavage system H protein [KO:K02437]
SPSK_09289  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
SPSK_09463  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
SPSK_09377  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
SPSK_00810  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
SPSK_00574  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SPSK_04247  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SPSK_04256  fructosyl amino acid oxidasesarcosine [KO:K00306] [EC:1.5.3.1 1.5.3.7]
SPSK_06205  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SPSK_00793  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
SPSK_06124  threonineeeee dehydratase [KO:K01754] [EC:4.3.1.19]
SPSK_07624  threonineeeee dehydratase [KO:K01754] [EC:4.3.1.19]
SPSK_05364  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
SPSK_09085  hypothetical protein [KO:K20498] [EC:4.3.1.18]
SPSK_03122  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ssck00010  Glycolysis / Gluconeogenesis
ssck00020  Citrate cycle (TCA cycle)
ssck00230  Purine metabolism
ssck00250  Alanine, aspartate and glutamate metabolism
ssck00270  Cysteine and methionine metabolism
ssck00290  Valine, leucine and isoleucine biosynthesis
ssck00300  Lysine biosynthesis
ssck00330  Arginine and proline metabolism
ssck00460  Cyanoamino acid metabolism
ssck00470  D-Amino acid metabolism
ssck00564  Glycerophospholipid metabolism
ssck00600  Sphingolipid metabolism
ssck00620  Pyruvate metabolism
ssck00630  Glyoxylate and dicarboxylate metabolism
ssck00640  Propanoate metabolism
ssck00680  Methane metabolism
ssck00860  Porphyrin metabolism
ssck00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system