KEGG   PATHWAY: swi03410
Entry
swi03410                    Pathway                                
Name
Base excision repair - Rhizorhabdus wittichii RW1
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
swi03410  Base excision repair
swi03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Rhizorhabdus wittichii RW1 [GN:swi]
Gene
Swit_0203  endonuclease III / DNA-(apurinic or apyrimidinic site) lyase [KO:K10773] [EC:3.2.2.- 4.2.99.18]
Swit_3206  Uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
Swit_4690  A/G-specific DNA-adenine glycosylase [KO:K03575] [EC:3.2.2.31]
Swit_4885  Formamidopyrimidine-DNA glycosylase / DNA-(apurinic or apyrimidinic site) lyase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
Swit_2427  HhH-GPD family protein [KO:K01247] [EC:3.2.2.21]
Swit_0547  DNA-3-methyladenine glycosylase II [KO:K01247] [EC:3.2.2.21]
Swit_4680  DNA-3-methyladenine glycosylase I [KO:K01246] [EC:3.2.2.20]
Swit_3959  Uracil-DNA glycosylase superfamily [KO:K03649] [EC:3.2.2.28]
Swit_1220  Uracil-DNA glycosylase superfamily [KO:K21929] [EC:3.2.2.27]
Swit_4099  Uracil-DNA glycosylase superfamily [KO:K21929] [EC:3.2.2.27]
Swit_5283  exodeoxyribonuclease III Xth [KO:K01142] [EC:3.1.11.2]
Swit_3788  exodeoxyribonuclease III Xth [KO:K01142] [EC:3.1.11.2]
Swit_3911  Exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
Swit_0450  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Swit_4733  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Swit_4727  DNA ligase, NAD-dependent [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
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