KEGG   PATHWAY: syan00270
Entry
syan00270                   Pathway                                
Name
Cysteine and methionine metabolism - Streptomyces yangpuensis
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
syan00270  Cysteine and methionine metabolism
syan00270

Module
syan_M00035  Methionine degradation [PATH:syan00270]
syan_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:syan00270]
Other DBs
GO: 0006534 0006555
Organism
Streptomyces yangpuensis [GN:syan]
Gene
NRK68_25840  pyridoxal-phosphate dependent enzyme [KO:K01738] [EC:2.5.1.47]
NRK68_04015  PLP-dependent cysteine synthase family protein [KO:K01738] [EC:2.5.1.47]
NRK68_16855  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
NRK68_13610  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
NRK68_26315  mmuM; homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]
NRK68_07365  metH; methionine synthase [KO:K00548] [EC:2.1.1.13]
NRK68_06485  metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]
NRK68_18005  polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]
NRK68_14100  S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
NRK68_09435  pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
NRK68_00500  amidohydrolase family protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]
NRK68_12740  DNA cytosine methyltransferase [KO:K00558] [EC:2.1.1.37]
NRK68_13365  ahcY; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
NRK68_22870  pyridoxal-phosphate dependent enzyme [KO:K01505] [EC:3.5.99.7]
NRK68_18175  aspartate kinase [KO:K00928] [EC:2.7.2.4]
NRK68_18480  aspartate kinase [KO:K00928] [EC:2.7.2.4]
NRK68_11935  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NRK68_18180  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NRK68_23415  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NRK68_21255  cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
NRK68_24265  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
NRK68_06850  aminodeoxychorismate lyase [KO:K00826] [EC:2.6.1.42]
NRK68_30050  egtA; ergothioneine biosynthesis glutamate--cysteine ligase EgtA [KO:K01919] [EC:6.3.2.2]
NRK68_20035  pyridoxal phosphate-dependent aminotransferase [KO:K00812] [EC:2.6.1.1]
NRK68_27995  aromatic amino acid transaminase [KO:K00813] [EC:2.6.1.1]
NRK68_25880  sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
NRK68_15700  sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
NRK68_23135  sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
NRK68_20745  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
NRK68_23955  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
NRK68_24205  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NRK68_14970  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
NRK68_29180  PLP-dependent cysteine synthase family protein [KO:K22847] [EC:2.8.5.1]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
syan00010  Glycolysis / Gluconeogenesis
syan00250  Alanine, aspartate and glutamate metabolism
syan00260  Glycine, serine and threonine metabolism
syan00290  Valine, leucine and isoleucine biosynthesis
syan00430  Taurine and hypotaurine metabolism
syan00480  Glutathione metabolism
syan00620  Pyruvate metabolism
syan00640  Propanoate metabolism
syan00770  Pantothenate and CoA biosynthesis
syan00900  Terpenoid backbone biosynthesis
syan00920  Sulfur metabolism
KO pathway
ko00270   
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