KEGG   PATHWAY: tala03013
Entry
tala03013                   Pathway                                
Name
Nucleocytoplasmic transport - Tyto alba (Barn owl)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tala03013  Nucleocytoplasmic transport
tala03013

Other DBs
GO: 0050658
Organism
Tyto alba (Barn owl) [GN:tala]
Gene
116959525  AAAS; aladin isoform X1 [KO:K14320]
104367540  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
104355484  GLE1; nucleoporin GLE1 [KO:K18723]
104364434  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
116959024  mRNA export factor [KO:K14298]
104367851  mRNA export factor [KO:K14298]
104366852  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
104367624  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
104357643  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
104363684  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
104358513  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
104358089  UBE2I; SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
104357523  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
104358755  small ubiquitin-related modifier 3 [KO:K12160]
104362385  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
104358726  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
104366359  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
104356370  SEC13; protein SEC13 homolog [KO:K14004]
104363155  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
104355664  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
104355964  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
104368332  NUP43; nucleoporin Nup43 [KO:K14305]
104356119  NUP37; nucleoporin Nup37 [KO:K14302]
104356809  protein ELYS isoform X1 [KO:K25129]
116962407  nuclear pore glycoprotein p62 isoform X1 [KO:K14306]
122154832  nuclear pore glycoprotein p62-like [KO:K14306]
104355858  NUP58; nucleoporin p58/p45 isoform X3 [KO:K14307]
104363089  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
104358774  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
104369351  NUP188; nucleoporin NUP188 [KO:K14311]
104365814  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
104362490  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
104356074  NUP35; nucleoporin NUP35 [KO:K14313]
104364139  NDC1; nucleoporin NDC1 [KO:K14315]
104363370  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
116965146  nuclear envelope pore membrane protein POM 121C [KO:K14316]
104356015  TMEM33; transmembrane protein 33 [KO:K20724]
104368381  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
104362234  NUP50; nuclear pore complex protein Nup50 isoform X2 [KO:K14295]
104357174  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
104368310  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
104355662  KPNA1; importin subunit alpha-5 [KO:K23940]
104365569  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
104356163  KPNA7; importin subunit alpha-8 [KO:K15043]
104361547  KPNA4; importin subunit alpha-3 isoform X2 [KO:K23583]
104365678  KPNA3; importin subunit alpha-4 [KO:K23583]
104355907  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
104355655  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
104368677  KPNB1; importin subunit beta-1 isoform X1 [KO:K14293]
104358608  TNPO1; transportin-1 isoform X1 [KO:K18752]
104364629  IPO5; importin-5 [KO:K20222]
104367490  IPO7; importin-7 [KO:K20223]
104365713  IPO8; importin-8 isoform X3 [KO:K18755]
104362458  IPO9; importin-9 isoform X1 [KO:K20224]
104369173  IPO11; importin-11 [KO:K25201]
104368078  IPO13; importin-13 isoform X1 [KO:K25202]
104357827  SNUPN; snurportin-1 isoform X1 [KO:K13151]
104366604  XPO1; exportin-1 [KO:K14290]
104367140  CSE1L; exportin-2 [KO:K18423]
104368653  XPOT; exportin-T [KO:K14288]
104365007  XPO4; exportin-4 isoform X1 [KO:K25203]
104361422  XPO5; exportin-5 isoform X1 [KO:K14289]
104368600  XPO6; exportin-6 isoform X1 [KO:K25204]
104359789  XPO7; exportin-7 isoform X3 [KO:K18460]
104355488  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
104365690  RAN; GTP-binding nuclear protein Ran [KO:K07936]
104357074  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
104360986  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
104358504  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
104358223  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104359307  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
104356807  nuclear cap-binding protein subunit 2 [KO:K12883]
104362191  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
116962574  RBM8A; RNA-binding protein 8A [KO:K12876]
104361000  MAGOH; protein mago nashi homolog [KO:K12877]
104358860  CASC3; protein CASC3 isoform X1 [KO:K14323]
104355947  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104363936  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104360228  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
104361888  PNN; pinin [KO:K13114]
104362367  ALYREF; THO complex subunit 4 [KO:K12881]
104358164  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104357683  UPF2; regulator of nonsense transcripts 2 isoform X2 [KO:K14327]
104363074  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
104356020  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
104356460  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
104357957  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
116960340  PYM1; partner of Y14 and mago [KO:K14294]
104364718  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
104358885  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
104360785  THOC5; THO complex subunit 5 homolog [KO:K13174]
104356369  THOC7; THO complex subunit 7 homolog [KO:K13176]
104355694  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tala03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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