KEGG   PATHWAY: tda03013
Entry
tda03013                    Pathway                                
Name
Nucleocytoplasmic transport - Teleopsis dalmanni (Malaysian stalk-eyed fly)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tda03013  Nucleocytoplasmic transport
tda03013

Other DBs
GO: 0050658
Organism
Teleopsis dalmanni (Malaysian stalk-eyed fly) [GN:tda]
Gene
119671399  aladin-like [KO:K14320]
119671403  aladin-like [KO:K14320]
119670676  nucleoporin NUP42-like [KO:K14321]
119671026  putative uncharacterized protein DDB_G0271606 [KO:K14321]
119680681  nucleoporin Gle1 [KO:K18723]
119685970  DEAD-box helicase Dbp80-like isoform X1 [KO:K18655] [EC:5.6.2.7]
119680305  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
119680710  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
119675528  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
119685421  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
119679838  mRNA export factor-like [KO:K14298]
119679840  mRNA export factor-like [KO:K14298]
119682336  mRNA export factor [KO:K14298]
119682459  mRNA export factor-like [KO:K14298]
119683929  mRNA export factor-like [KO:K14298]
119676430  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
119677607  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
119678079  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
119666468  nuclear pore complex protein Nup88-like [KO:K14318]
119689152  ran GTPase-activating protein-like [KO:K14319]
119661980  ran GTPase-activating protein-like [KO:K14319]
119679674  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
119679676  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
119688954  SUMO-conjugating enzyme UBC9-B [KO:K10577]
119671369  ubiquitin-like protein SMT3 [KO:K12160]
119671589  small ubiquitin-related modifier 2-like [KO:K12160]
119671617  small ubiquitin-related modifier 2-like [KO:K12160]
119674654  ubiquitin-like protein SMT3 [KO:K12160]
119670283  nuclear pore complex protein Nup160 homolog isoform X1 [KO:K14303]
119680682  nuclear pore complex protein Nup75-like [KO:K14304]
119674504  nuclear pore complex protein Nup75-like [KO:K14304]
119674505  nuclear pore complex protein Nup75-like [KO:K14304]
119683706  protein SEC13 homolog [KO:K14004]
119679416  nuclear pore complex protein Nup107 [KO:K14301]
119679341  nuclear pore complex protein Nup133-like [KO:K14300]
119679868  nucleoporin seh1 [KO:K14299]
119685074  nucleoporin seh1 [KO:K14299]
119680752  nucleoporin Nup43-like [KO:K14305]
119685227  nucleoporin Nup43-like [KO:K14305]
119674554  nucleoporin Nup37-like [KO:K14302]
119677718  nucleoporin Nup37-like [KO:K14302]
119679659  nuclear pore glycoprotein p62 [KO:K14306]
119678426  nuclear pore complex protein Nup58 [KO:K14307]
119685498  probable nucleoporin Nup54 [KO:K14308]
119685527  uncharacterized protein LOC119685527 [KO:K14310]
119683664  nucleoporin NUP188 [KO:K14311]
119687197  nuclear pore complex protein Nup154-like [KO:K14312]
119671990  nuclear pore complex protein Nup93-1-like [KO:K14309]
119670546  nucleoporin Nup35 [KO:K14313]
119683513  nucleoporin Ndc1 [KO:K14315]
119674783  nuclear pore membrane glycoprotein 210-like [KO:K14314]
119677023  nuclear pore membrane glycoprotein 210-like [KO:K14314]
119677815  nuclear pore membrane glycoprotein 210-like [KO:K14314]
119689431  Krueppel homolog 2 [KO:K20724]
119675156  nucleoprotein TPR-like [KO:K09291]
119684058  nucleoprotein TPR-like [KO:K09291]
119685283  nucleoprotein TPR-like [KO:K09291]
119682037  nuclear pore complex protein Nup50 [KO:K14295]
119669990  importin subunit alpha-like [KO:K15043]
119669999  importin subunit alpha-like [KO:K15043]
119670305  importin subunit alpha-like [KO:K15043]
119689255  importin subunit alpha [KO:K15043]
119666753  importin subunit alpha-like [KO:K15043]
119667594  importin subunit alpha-like [KO:K15043]
119678745  importin subunit alpha-3 isoform X1 [KO:K23583]
119678797  importin subunit alpha-3-like [KO:K23583]
119676557  importin subunit alpha-3-like [KO:K23583]
119676572  importin subunit alpha-3-like [KO:K23583]
119677618  importin subunit alpha-3-like [KO:K23583]
119663061  importin subunit alpha-3-like [KO:K23583]
119667897  importin subunit alpha-7 [KO:K15042]
119689368  importin subunit beta [KO:K14293]
119675464  importin subunit beta-like [KO:K14293]
119678505  transportin-1-like [KO:K18752]
119678346  transportin-1-like [KO:K18752]
119679438  transportin-3-like [KO:K15436]
119687952  transportin-3 isoform X1 [KO:K15436]
119672514  importin-4-like [KO:K20221]
119681016  importin-5-like [KO:K20222]
119681813  importin-5-like [KO:K20222]
119673840  importin-5 [KO:K20222]
119669094  importin-7 isoform X1 [KO:K20223]
119683076  importin-9 [KO:K20224]
119678747  importin-11 [KO:K25201]
119679604  importin-13 [KO:K25202]
119669467  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X1 [KO:K13151]
119677599  snurportin-1 [KO:K13151]
119687210  exportin-1 [KO:K14290]
119662712  exportin-2 [KO:K18423]
119665141  exportin-5-like [KO:K14289]
119665662  exportin-5 [KO:K14289]
119666488  exportin-5-like [KO:K14289]
119667766  exportin-5-like [KO:K14289]
119663484  exportin-5-like [KO:K14289]
119670276  exportin-6 [KO:K25204]
119671050  ran-binding protein 16 [KO:K18460]
119666988  ran-binding protein 16-like [KO:K18460]
119667823  GTP-binding nuclear protein Ran [KO:K07936]
119679160  elongation factor 1-alpha 2 [KO:K03231]
119679491  elongation factor 1-alpha 1 [KO:K03231]
119680605  elongation factor 1-alpha 1 [KO:K03231]
119689771  phosphorylated adapter RNA export protein-like [KO:K14291]
119689953  phosphorylated adapter RNA export protein-like [KO:K14291]
119678271  phosphorylated adapter RNA export protein [KO:K14291]
119665933  nuclear cap-binding protein subunit 1 [KO:K12882]
119679168  nuclear cap-binding protein subunit 2 [KO:K12883]
119689334  nuclear cap-binding protein subunit 2-like [KO:K12883]
119689353  nuclear cap-binding protein subunit 2-like [KO:K12883]
119689388  nuclear cap-binding protein subunit 2-like [KO:K12883]
119689631  nuclear cap-binding protein subunit 2-like [KO:K12883]
119690032  nuclear cap-binding protein subunit 2-like [KO:K12883]
119673310  nuclear cap-binding protein subunit 2-like [KO:K12883]
119678408  nuclear cap-binding protein subunit 2 [KO:K12883]
119670114  60S ribosomal export protein NMD3 [KO:K07562]
119678768  RNA-binding protein 8A [KO:K12876]
119681490  RNA-binding protein 8A [KO:K12876]
119664299  RNA-binding protein 8A-like [KO:K12876]
119680803  protein mago nashi [KO:K12877]
119679445  protein CASC3-like [KO:K14323]
119680271  protein CASC3-like [KO:K14323]
119679192  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119677702  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119687400  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
119681007  histone deacetylase complex subunit SAP18 [KO:K14324]
119678596  RNA-binding protein with serine-rich domain 1-B [KO:K14325]
119682847  pinin [KO:K13114]
119687083  THO complex subunit 4B-like [KO:K12881]
119687086  THO complex subunit 4B-like [KO:K12881]
119679628  THO complex subunit 4A-like [KO:K12881]
119679629  aly/REF export factor 2-like [KO:K12881]
119674361  uncharacterized protein LOC119674361 [KO:K12881]
119683829  uncharacterized protein LOC119683829 [KO:K12881]
119683930  uncharacterized protein LOC119683930 isoform X1 [KO:K12881]
119684364  uncharacterized protein LOC119684364 [KO:K12881]
119677987  THO complex subunit 4 [KO:K12881]
119667526  THO complex subunit 4-A-like [KO:K12881]
119667527  THO complex subunit 4-A-like [KO:K12881]
119667528  THO complex subunit 4-A-like [KO:K12881]
119667530  THO complex subunit 4-A-like [KO:K12881]
119667531  THO complex subunit 4-A-like [KO:K12881]
119661803  aly/REF export factor 2-like [KO:K12881]
119661806  aly/REF export factor 2-like [KO:K12881]
119671322  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119672009  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119672705  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119669176  regulator of nonsense transcripts 2-like isoform X1 [KO:K14327]
119670686  regulator of nonsense transcripts 2-like isoform X1 [KO:K14327]
119682306  regulator of nonsense transcripts 3B-like [KO:K14328]
119669713  nuclear RNA export factor 1 [KO:K14284]
119686994  NTF2-related export protein-like [KO:K14285]
119689793  NTF2-related export protein-like [KO:K14285]
119683415  NTF2-related export protein-like [KO:K14285]
119683721  NTF2-related export protein-like [KO:K14285]
119684537  NTF2-related export protein [KO:K14285]
119661885  uncharacterized protein LOC119661885 [KO:K14285]
119662157  uncharacterized protein LOC119662157 [KO:K14285]
119662474  NTF2-related export protein-like [KO:K14285]
119687312  ATP-dependent RNA helicase WM6-like [KO:K12812] [EC:5.6.2.7]
119687313  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
119672916  partner of Y14 and mago-like [KO:K14294]
119668885  partner of Y14 and mago-like [KO:K14294]
119674633  THO complex subunit 1 [KO:K12878]
119676137  THO complex subunit 1-like [KO:K12878]
119662577  THO complex subunit 2 isoform X1 [KO:K12879]
119679391  THO complex subunit 5-like isoform X1 [KO:K13174]
119681443  THO complex subunit 6 [KO:K13175]
119679866  THO complex protein 7 [KO:K13176]
119680337  THO complex subunit 3-like [KO:K12880]
119680997  THO complex subunit 3-like [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tda03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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