KEGG   PATHWAY: tdc00053
Entry
tdc00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Triticum dicoccoides (wild emmer wheat)
Class
Metabolism; Carbohydrate metabolism
Pathway map
tdc00053  Ascorbate and aldarate metabolism
tdc00053

Module
tdc_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:tdc00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Triticum dicoccoides (wild emmer wheat) [GN:tdc]
Gene
119293368  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
119311874  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
119294844  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
119295449  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
119286325  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
119303200  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
119286871  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
119289103  UDP-glucose 6-dehydrogenase 2-like [KO:K00012] [EC:1.1.1.22]
119329157  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
119337370  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
119314558  probable glucuronokinase 2 [KO:K16190] [EC:2.7.1.43]
119323422  probable glucuronokinase 2 [KO:K16190] [EC:2.7.1.43]
119329804  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
119337574  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
119344880  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119347036  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119347052  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119347090  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119347102  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119347114  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119277590  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119277592  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119349998  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119350550  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119316253  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119281991  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
119282010  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119282022  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119282034  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119282046  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119282058  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119282085  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119299592  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119299636  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119334295  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119269580  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119269581  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
119358736  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119308177  aldose reductase [KO:K00002] [EC:1.1.1.2]
119274515  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
119326322  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
119343115  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
119344251  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119292133  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119292134  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119328328  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119311350  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119311351  probable L-gulonolactone oxidase 1 [KO:K00103] [EC:1.1.3.8]
119294227  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119294330  probable L-gulonolactone oxidase 1 [KO:K00103] [EC:1.1.3.8]
119294351  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119294357  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
119314791  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119331420  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119352850  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119316267  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
119331856  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119331883  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119298602  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119282497  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119300514  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
119300517  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
119335486  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119301285  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119336168  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119336282  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119302670  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119321288  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
119357442  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119304219  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
119311151  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
119292229  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
119349586  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
119302474  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
119277841  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
119295341  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
119299042  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
119300690  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
119286345  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
119269835  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
119307370  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
119308074  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
119295985  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
119285949  inositol monophosphatase 3-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
119275762  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
119267870  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
119299280  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
119307458  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
119308312  L-galactono-1,4-lactone dehydrogenase 2, mitochondrial [KO:K00225] [EC:1.3.2.3]
119310972  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
119331212  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
119332211  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
119318268  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
119285124  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
119302170  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
119323275  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
119340988  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
119341212  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
119290988  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
119326798  monodehydroascorbate reductase 1, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
119326800  monodehydroascorbate reductase 2, peroxisomal [KO:K08232] [EC:1.6.5.4]
119294520  monodehydroascorbate reductase 3, cytosolic-like [KO:K08232] [EC:1.6.5.4]
119329526  monodehydroascorbate reductase 4, cytosolic [KO:K08232] [EC:1.6.5.4]
119317587  monodehydroascorbate reductase 1, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
119317589  monodehydroascorbate reductase 2, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
119334670  monodehydroascorbate reductase 5, chlorplastic-like [KO:K08232] [EC:1.6.5.4]
119335448  monodehydroascorbate reductase 5, chlorplastic [KO:K08232] [EC:1.6.5.4]
119287164  monodehydroascorbate reductase 3, cytosolic [KO:K08232] [EC:1.6.5.4]
119338888  monodehydroascorbate reductase 4, cytosolic-like isoform X1 [KO:K08232] [EC:1.6.5.4]
119364322  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
119328631  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
119348043  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
119353103  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
119300763  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
119355195  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
119318682  probable L-ascorbate peroxidase 8, chloroplastic [KO:K00434] [EC:1.11.1.11]
119336473  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
119285357  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
119358815  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
119362135  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
119362185  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
119290733  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
119308144  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
119325534  probable L-ascorbate peroxidase 8, chloroplastic [KO:K00434] [EC:1.11.1.11]
119330127  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
119318465  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
119337564  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
119360867  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
119277380  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
119312162  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
119329395  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
119329827  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
119337311  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
119269387  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
119339323  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
119308384  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
119365057  aldehyde dehydrogenase family 3 member F1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
119294514  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
119329488  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
119295284  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
119317282  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
119300762  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
119355916  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
119319575  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
119286492  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
119337792  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
119323793  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
119324217  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
119308143  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
119309456  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
119301583  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
tdc00020  Citrate cycle (TCA cycle)
tdc00040  Pentose and glucuronate interconversions
tdc00051  Fructose and mannose metabolism
tdc00520  Amino sugar and nucleotide sugar metabolism
tdc00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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