KEGG   PATHWAY: tpro00260
Entry
tpro00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Salipiger profundus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
tpro00260  Glycine, serine and threonine metabolism
tpro00260

Module
tpro_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:tpro00260]
tpro_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:tpro00260]
tpro_M00555  Betaine biosynthesis, choline => betaine [PATH:tpro00260]
tpro_M00621  Glycine cleavage system [PATH:tpro00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salipiger profundus [GN:tpro]
Gene
Ga0080559_TMP3219  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Ga0080559_TMP4871  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Ga0080559_TMP2061  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Ga0080559_TMP3061  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Ga0080559_TMP1060  threonine synthase [KO:K01733] [EC:4.2.3.1]
Ga0080559_TMP2586  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Ga0080559_TMP3175  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Ga0080559_TMP3051  alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Ga0080559_TMP3240  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Ga0080559_TMP1100  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Ga0080559_TMP2617  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Ga0080559_TMP3335  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Ga0080559_TMP5166  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Ga0080559_TMP3838  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Ga0080559_TMP2802  putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Ga0080559_TMP1698  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
Ga0080559_TMP4101  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Ga0080559_TMP3746  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Ga0080559_TMP2252  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Ga0080559_TMP2251  phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]
Ga0080559_TMP1292  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Ga0080559_TMP3416  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
Ga0080559_TMP1803  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Ga0080559_TMP4887  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Ga0080559_TMP1805  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Ga0080559_TMP1691  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Ga0080559_TMP4733  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Ga0080559_TMP1150  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Ga0080559_TMP1804  glycine cleavage system H protein [KO:K02437]
Ga0080559_TMP2015  creatinase [KO:K08688] [EC:3.5.3.3]
Ga0080559_TMP2491  CDP-diacylglycerol---serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Ga0080559_TMP4890  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Ga0080559_TMP2121  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Ga0080559_TMP2120  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Ga0080559_TMP5095  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Ga0080559_TMP3154  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Ga0080559_TMP3150  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Ga0080559_TMP3155  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Ga0080559_TMP3153  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Ga0080559_TMP602  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Ga0080559_TMP2683  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Ga0080559_TMP1919  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Ga0080559_TMP2172  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
Ga0080559_TMP4351  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
Ga0080559_TMP3463  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Ga0080559_TMP4869  diaminobutyrate aminotransferase apoenzyme [KO:K00836] [EC:2.6.1.76]
Ga0080559_TMP4868  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
Ga0080559_TMP4870  ectoine synthase [KO:K06720] [EC:4.2.1.108]
Ga0080559_TMP4044  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Ga0080559_TMP3721  ectoine hydrolase [KO:K15783] [EC:3.5.4.44]
Ga0080559_TMP1087  ectoine hydrolase [KO:K15783] [EC:3.5.4.44]
Ga0080559_TMP4597  L-2,4-diaminobutyrate transaminase [KO:K15785] [EC:2.6.1.76]
Ga0080559_TMP4596  succinate semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
tpro00010  Glycolysis / Gluconeogenesis
tpro00020  Citrate cycle (TCA cycle)
tpro00230  Purine metabolism
tpro00250  Alanine, aspartate and glutamate metabolism
tpro00270  Cysteine and methionine metabolism
tpro00290  Valine, leucine and isoleucine biosynthesis
tpro00300  Lysine biosynthesis
tpro00330  Arginine and proline metabolism
tpro00460  Cyanoamino acid metabolism
tpro00470  D-Amino acid metabolism
tpro00564  Glycerophospholipid metabolism
tpro00620  Pyruvate metabolism
tpro00630  Glyoxylate and dicarboxylate metabolism
tpro00640  Propanoate metabolism
tpro00680  Methane metabolism
tpro00860  Porphyrin metabolism
tpro00920  Sulfur metabolism
KO pathway
ko00260   
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