KEGG   PATHWAY: vlg04390
Entry
vlg04390                    Pathway                                
Name
Hippo signaling pathway - Vulpes lagopus (Arctic fox)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
vlg04390  Hippo signaling pathway
vlg04390

Other DBs
GO: 0035329
Organism
Vulpes lagopus (Arctic fox) [GN:vlg]
Gene
121473023  CRB2; protein crumbs homolog 2 [KO:K16681]
121496490  CRB1; protein crumbs homolog 1 isoform X1 [KO:K16681]
121496593  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
121481909  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
121478163  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
121500588  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
121499817  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
121477501  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
121499695  PATJ; inaD-like protein isoform X1 [KO:K06092]
121492767  PALS1; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
121482935  AMOT; angiomotin isoform X1 [KO:K16819]
121499555  YAP1; transcriptional coactivator YAP1 isoform X1 [KO:K16687]
121478977  WWTR1; WW domain-containing transcription regulator protein 1 [KO:K16820]
121500345  CDH1; cadherin-1 [KO:K05689]
121500539  cadherin-1-like [KO:K05689]
121485225  Wilms tumor protein 1-interacting protein [KO:K16682]
121493559  AJUBA; LIM domain-containing protein ajuba [KO:K16682]
121495299  LIMD1; LIM domain-containing protein 1 [KO:K16682]
121475470  NF2; merlin isoform X1 [KO:K16684]
121487508  WWC1; protein KIBRA isoform X1 [KO:K16685]
121484659  FRMD1; FERM domain-containing protein 1 [KO:K16821]
121493528  FRMD6; FERM domain-containing protein 6 isoform X1 [KO:K16822]
121492966  SAV1; protein salvador homolog 1 [KO:K16686]
121498796  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
121474094  RASSF6; ras association domain-containing protein 6 [KO:K09854]
121494626  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
121489947  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121495681  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121484445  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
121499587  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
121490126  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
121484411  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
121496949  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
121497471  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121484488  LATS1; serine/threonine-protein kinase LATS1 [KO:K08791] [EC:2.7.11.1]
121497072  LATS2; serine/threonine-protein kinase LATS2 [KO:K08791] [EC:2.7.11.1]
121472739  MOB1B; MOB kinase activator 1B isoform X1 [KO:K06685]
121491683  MOB1A; MOB kinase activator 1A isoform X1 [KO:K06685]
121475295  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
121472051  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121491037  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121485747  TP53BP2; apoptosis-stimulating of p53 protein 2 isoform X1 [KO:K16823]
121473797  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
121499619  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
121498672  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
121486853  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
121476318  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
121483376  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
121499760  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
121487209  DLG5; disks large homolog 5 isoform X1 [KO:K24050]
121472841  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
121491223  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
121488189  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
121484364  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
121500183  TP73; tumor protein p73 [KO:K10148]
121485860  BBC3; bcl-2-binding component 3 [KO:K10132]
121480373  TEAD4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448]
121476273  TEAD1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
121485149  TEAD2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
121486849  TEAD3; transcriptional enhancer factor TEF-5 [KO:K09448]
121485523  CCN2; CCN family member 2 [KO:K06827]
121482121  GLI2; zinc finger protein GLI2 [KO:K16798]
121473607  AREG; amphiregulin [KO:K09782]
121473483  alpha-fetoprotein [KO:K16144]
121473389  alpha-fetoprotein-like isoform X1 [KO:K16144]
121479390  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
121496849  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121485274  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
121471376  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
121493196  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
121495382  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121478523  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121493898  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
121484675  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
121482745  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121482063  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121487837  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
121478407  BMP2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
121493806  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
121492914  BMP5; bone morphogenetic protein 5 [KO:K04663]
121499610  BMP6; bone morphogenetic protein 6 [KO:K16620]
121477686  BMP7; bone morphogenetic protein 7 [KO:K16621]
121481396  BMP8A; bone morphogenetic protein 8A [KO:K16622]
121478183  GDF5; growth/differentiation factor 5 [KO:K04664]
121498524  GDF6; growth/differentiation factor 6 [KO:K20012]
121490433  GDF7; growth/differentiation factor 7 [KO:K20013]
121495625  AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
121486306  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
121493624  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
121480503  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
121481168  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
121478079  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
121490391  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
121490883  LOW QUALITY PROTEIN: DNA-binding protein inhibitor ID-2-like [KO:K17693]
121480178  WNT1; proto-oncogene Wnt-1 isoform X1 [KO:K03209]
121474438  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
121490731  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
121474007  WNT3; proto-oncogene Wnt-3 [KO:K00312]
121474467  WNT3A; protein Wnt-3a [KO:K00312]
121498205  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
121479913  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
121495641  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
121480717  WNT6; protein Wnt-6 [KO:K00445]
121490476  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
121495152  WNT7A; protein Wnt-7a [KO:K00572]
121476849  WNT8B; protein Wnt-8b [KO:K00714]
121495235  WNT8A; protein Wnt-8a [KO:K00714]
121474006  WNT9B; protein Wnt-9b [KO:K01064]
121475053  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
121480841  WNT10A; protein Wnt-10a [KO:K01357]
121480042  WNT10B; protein Wnt-10b [KO:K01357]
121475935  WNT11; protein Wnt-11 [KO:K01384]
121474824  WNT16; protein Wnt-16 [KO:K01558]
121480659  FZD7; frizzled-7 isoform X1 [KO:K02432]
121474752  FZD1; frizzled-1 [KO:K02432]
121472594  FZD2; frizzled-2 [KO:K02235]
121498183  FZD3; frizzled-3 isoform X1 [KO:K02329]
121476036  FZD4; frizzled-4 isoform X1 [KO:K02354]
121480532  FZD5; frizzled-5 [KO:K02375]
121498057  FZD8; frizzled-8 [KO:K02375]
121498902  FZD6; frizzled-6 isoform X1 [KO:K02376]
121475662  FZD10; frizzled-10 [KO:K02842]
121486703  FZD9; frizzled-9 [KO:K02842]
121477470  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
121499761  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
121499953  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121485026  14-3-3 protein zeta/delta-like [KO:K16197]
121477394  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
121478041  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
121495972  14-3-3 protein zeta/delta-like [KO:K16197]
121498818  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
121491667  YWHAQ; 14-3-3 protein theta [KO:K16197]
121473268  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
121475719  YWHAH; 14-3-3 protein eta [KO:K16198]
121487191  YWHAG; 14-3-3 protein gamma [KO:K16198]
121489623  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121478755  CTNNB1; catenin beta-1 [KO:K02105]
121489860  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121495587  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
121486746  AXIN1; axin-1 isoform X1 [KO:K02157]
121473774  AXIN2; axin-2 isoform X1 [KO:K04385]
121477249  NKD2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
121498070  NKD1; protein naked cuticle homolog 1 [KO:K03213]
121495797  TCF7; transcription factor 7 isoform X1 [KO:K02620]
121490511  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
121485032  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
121493895  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
121499098  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
121501724  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
121479990  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
121499073  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121477240  SOX2; transcription factor SOX-2 [KO:K16796]
121498442  SNAI2; zinc finger protein SNAI2 [KO:K05706]
121500037  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
121500437  baculoviral IAP repeat-containing protein 3 [KO:K16060]
121473578  ACTG1; actin, cytoplasmic 2 [KO:K05692]
121483270  actin, cytoplasmic 1 [KO:K05692]
121477556  actin, cytoplasmic 2-like [KO:K05692]
121487542  ACTB; actin, cytoplasmic 1 [KO:K05692]
121486782  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
121491957  CTNNA2; catenin alpha-2 isoform X1 [KO:K05691]
121494415  CTNNA1; catenin alpha-1 [KO:K05691]
Reference
PMID:22750148
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21874053
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
PMID:21084559
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:23034192
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:22658639
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:21324984
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
PMID:18955139
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
PMID:20945341
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
PMID:18328423
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
PMID:19846288
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
PMID:17975546
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
PMID:22683405
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:22895435
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
PMID:22153608
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
PMID:21376238
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
vlg04120  Ubiquitin mediated proteolysis
vlg04310  Wnt signaling pathway
vlg04350  TGF-beta signaling pathway
vlg04520  Adherens junction
vlg04530  Tight junction
KO pathway
ko04390   
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