KEGG   PATHWAY: yim00260
Entry
yim00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Yimella sp. cx-51
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
yim00260  Glycine, serine and threonine metabolism
yim00260

Module
yim_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:yim00260]
yim_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:yim00260]
yim_M00555  Betaine biosynthesis, choline => betaine [PATH:yim00260]
yim_M00621  Glycine cleavage system [PATH:yim00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Yimella sp. cx-51 [GN:yim]
Gene
J5M86_01580  aspartate kinase [KO:K00928] [EC:2.7.2.4]
J5M86_01585  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
J5M86_01590  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
J5M86_10575  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
J5M86_10565  homoserine kinase [KO:K00872] [EC:2.7.1.39]
J5M86_10570  threonine synthase [KO:K01733] [EC:4.2.3.1]
J5M86_12210  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
J5M86_00615  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
J5M86_10510  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
J5M86_13130  glycerate kinase [KO:K00865] [EC:2.7.1.165]
J5M86_08985  glycerate kinase [KO:K00865] [EC:2.7.1.165]
J5M86_12450  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
J5M86_09325  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
J5M86_02885  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
J5M86_07165  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
J5M86_10080  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
J5M86_10075  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
J5M86_07935  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
J5M86_09040  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
J5M86_06220  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J5M86_09055  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J5M86_07960  gcvH; glycine cleavage system protein GcvH [KO:K02437]
J5M86_00600  aminopeptidase P family protein [KO:K08688] [EC:3.5.3.3]
J5M86_00655  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
J5M86_00650  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
J5M86_05275  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
J5M86_00240  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
J5M86_00630  FAD-dependent oxidoreductase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
J5M86_00620  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
J5M86_00635  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
J5M86_00625  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
J5M86_03290  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
J5M86_05250  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
J5M86_00105  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
J5M86_06750  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
J5M86_06745  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
J5M86_08015  TrpB-like pyridoxal phosphate-dependent enzyme [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
yim00010  Glycolysis / Gluconeogenesis
yim00020  Citrate cycle (TCA cycle)
yim00230  Purine metabolism
yim00250  Alanine, aspartate and glutamate metabolism
yim00270  Cysteine and methionine metabolism
yim00290  Valine, leucine and isoleucine biosynthesis
yim00300  Lysine biosynthesis
yim00330  Arginine and proline metabolism
yim00460  Cyanoamino acid metabolism
yim00470  D-Amino acid metabolism
yim00564  Glycerophospholipid metabolism
yim00600  Sphingolipid metabolism
yim00620  Pyruvate metabolism
yim00630  Glyoxylate and dicarboxylate metabolism
yim00640  Propanoate metabolism
yim00680  Methane metabolism
yim00860  Porphyrin metabolism
yim00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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