KEGG   PATHWAY: patr00260
Entry
patr00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pectobacterium atrosepticum JG10-08
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
patr00260  Glycine, serine and threonine metabolism
patr00260

Module
patr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:patr00260]
patr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:patr00260]
patr_M00555  Betaine biosynthesis, choline => betaine [PATH:patr00260]
patr_M00621  Glycine cleavage system [PATH:patr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pectobacterium atrosepticum JG10-08 [GN:patr]
Gene
EV46_19530  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EV46_19080  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EV46_21240  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EV46_20690  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EV46_19075  serine kinase [KO:K00872] [EC:2.7.1.39]
EV46_19070  threonine synthase [KO:K01733] [EC:4.2.3.1]
EV46_16115  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EV46_20130  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EV46_13295  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
EV46_00395  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EV46_17725  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EV46_06995  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
EV46_19110  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
EV46_19150  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EV46_12540  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
EV46_02415  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EV46_10810  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EV46_00870  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
EV46_00875  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
EV46_03245  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
EV46_03235  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
EV46_18565  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
EV46_03240  glycine cleavage system protein H [KO:K02437]
EV46_17430  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
EV46_08345  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EV46_08340  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EV46_20470  cysteine synthase [KO:K01697] [EC:4.2.1.22]
EV46_11460  serine dehydratase [KO:K01752] [EC:4.3.1.17]
EV46_15635  serine dehydratase [KO:K01752] [EC:4.3.1.17]
EV46_07935  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EV46_21075  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EV46_06505  aspartate racemase [KO:K25316] [EC:5.1.1.10]
EV46_11055  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EV46_11050  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EV46_10770  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
EV46_10775  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
patr00010  Glycolysis / Gluconeogenesis
patr00020  Citrate cycle (TCA cycle)
patr00230  Purine metabolism
patr00250  Alanine, aspartate and glutamate metabolism
patr00270  Cysteine and methionine metabolism
patr00290  Valine, leucine and isoleucine biosynthesis
patr00300  Lysine biosynthesis
patr00330  Arginine and proline metabolism
patr00460  Cyanoamino acid metabolism
patr00470  D-Amino acid metabolism
patr00564  Glycerophospholipid metabolism
patr00600  Sphingolipid metabolism
patr00620  Pyruvate metabolism
patr00630  Glyoxylate and dicarboxylate metabolism
patr00640  Propanoate metabolism
patr00680  Methane metabolism
patr00860  Porphyrin metabolism
patr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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