KEGG   PATHWAY: pcoo03013
Entry
pcoo03013                   Pathway                                
Name
Nucleocytoplasmic transport - Puma concolor (puma)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pcoo03013  Nucleocytoplasmic transport
pcoo03013

Other DBs
GO: 0050658
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112867243  AAAS; aladin [KO:K14320]
112866907  NUPL2; nucleoporin-like protein 2 [KO:K14321]
112863617  GLE1; nucleoporin GLE1 [KO:K18723]
112857400  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
112857411  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
112868961  RAE1; mRNA export factor [KO:K14298]
112865263  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
112849811  NUP214; nuclear pore complex protein Nup214 [KO:K14317]
112856965  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
112863436  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
112853253  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
112855039  small ubiquitin-related modifier 2-like [KO:K12160]
112849868  small ubiquitin-related modifier 2-like [KO:K12160]
112869470  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
112858011  small ubiquitin-related modifier 2-like isoform X1 [KO:K12160]
112864572  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
112870976  small ubiquitin-related modifier 2-like [KO:K12160]
112865182  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
112864557  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
112858369  SEC13; LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
112863603  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
112851539  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
112868248  SEH1L; nucleoporin SEH1 [KO:K14299]
112862486  NUP43; nucleoporin Nup43 [KO:K14305]
112863638  NUP37; nucleoporin Nup37 [KO:K14302]
112863147  AHCTF1; protein ELYS [KO:K25129]
112850819  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
112870684  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
112861164  NUP58; nucleoporin p58/p45 [KO:K14307]
112858351  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
112866674  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
112850011  NUP188; nucleoporin NUP188 homolog [KO:K14311]
112860978  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
112857495  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
112870334  NUP35; nucleoporin NUP35 [KO:K14313]
112872012  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
112851724  NUP210L; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210-like [KO:K14314]
112858025  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
112859901  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
112858374  TMEM33; transmembrane protein 33 [KO:K20724]
112857817  TPR; nucleoprotein TPR [KO:K09291]
112863522  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
112853627  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
112849915  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
112850303  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
112864717  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
112860114  KPNA7; importin subunit alpha-8 [KO:K15043]
112849516  KPNA4; importin subunit alpha-3 [KO:K23583]
112860825  KPNA3; importin subunit alpha-4 [KO:K23583]
112862302  KPNA5; importin subunit alpha-6 [KO:K15042]
112871164  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
112854077  KPNB1; importin subunit beta-1 [KO:K14293]
112861545  TNPO1; transportin-1 [KO:K18752]
112852296  TNPO2; LOW QUALITY PROTEIN: transportin-2 [KO:K18727]
112866647  TNPO3; transportin-3 isoform X1 [KO:K15436]
112855422  IPO4; importin-4 [KO:K20221]
112860752  IPO5; importin-5 [KO:K20222]
112865035  IPO7; importin-7 [KO:K20223]
112867305  IPO8; importin-8 [KO:K18755]
112857662  IPO9; importin-9 [KO:K20224]
112860907  IPO11; importin-11 [KO:K25201]
112871890  IPO13; importin-13 [KO:K25202]
112856058  SNUPN; snurportin-1 [KO:K13151]
112868878  XPO1; exportin-1 [KO:K14290]
112868787  CSE1L; exportin-2 isoform X1 [KO:K18423]
112863532  XPOT; exportin-T [KO:K14288]
112860291  XPO4; exportin-4 [KO:K25203]
112862796  XPO5; exportin-5 [KO:K14289]
112856500  XPO6; exportin-6 [KO:K25204]
112870011  XPO7; exportin-7 isoform X1 [KO:K18460]
112860387  RANBP17; ran-binding protein 17 [KO:K24115]
112854970  RAN; GTP-binding nuclear protein Ran [KO:K07936]
112862036  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
112869034  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
112865315  elongation factor 1-alpha, oocyte form-like [KO:K03231]
112871749  elongation factor 1-alpha, somatic form-like [KO:K03231]
112860689  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
112866831  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
112850315  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
112870680  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
112849726  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
112871924  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
112871833  MAGOH; protein mago nashi homolog isoform X1 [KO:K12877]
112867874  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
112854023  CASC3; LOW QUALITY PROTEIN: protein CASC3 [KO:K14323]
112864546  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
112855142  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
112860981  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
112855738  PNN; pinin [KO:K13114]
112852690  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
112867355  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
112870995  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
112860723  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
112868776  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
112870711  nuclear RNA export factor 3-like [KO:K14284]
112870713  nuclear RNA export factor 2-like [KO:K14284]
112870715  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112851890  NXF1; nuclear RNA export factor 1 [KO:K14284]
112869227  NXT1; NTF2-related export protein 1 [KO:K14285]
112871231  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
112853421  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
112871685  SRRM1; LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1 [KO:K13171]
112863896  PYM1; partner of Y14 and mago [KO:K14294]
112868288  THOC1; LOW QUALITY PROTEIN: THO complex subunit 1 [KO:K12878]
112870647  THOC2; THO complex subunit 2 [KO:K12879]
112870201  THOC5; THO complex subunit 5 homolog [KO:K13174]
112853184  THOC6; THO complex subunit 6 homolog [KO:K13175]
112852493  THOC7; THO complex subunit 7 homolog [KO:K13176]
112861250  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pcoo03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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