Entry Name Hedgehog signaling pathway - Phascolarctos cinereus (koala)
Description The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Phascolarctos cinereus (koala) [GN:
pcw ]
Gene 110193532 CUNH16orf52; uncharacterized protein C16orf52 homolog isoform X1 [KO:K23663 ]
110194552 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
110205541 DISP1; LOW QUALITY PROTEIN: protein dispatched homolog 1 [KO:K24680 ]
110209268 PTCH2; LOW QUALITY PROTEIN: protein patched homolog 2 [KO:K11101 ]
110211543 LRP2; low-density lipoprotein receptor-related protein 2 isoform X1 [KO:K06233 ]
110211697 KIF3A; LOW QUALITY PROTEIN: kinesin-like protein KIF3A [KO:K10394 ]
110212306 FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362 ]
110212894 EFCAB7; EF-hand calcium-binding domain-containing protein 7 [KO:K23852 ]
110217013 HHATL; protein-cysteine N-palmitoyltransferase HHAT-like protein [KO:K24679 ]
110218049 CDON; cell adhesion molecule-related/down-regulated by oncogenes [KO:K20033 ]
110218964 SCUBE2; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [KO:K24706 ]
110219728 MEGF8; LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8 [KO:K23664 ]
110222721 HHAT; protein-cysteine N-palmitoyltransferase HHAT isoform X1 [KO:K24678 ]
Compound Reference Authors Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
Title Hedgehog receptor function during craniofacial development.
Journal Reference Authors Briscoe J, Therond PP
Title The mechanisms of Hedgehog signalling and its roles in development and disease.
Journal Reference Authors Alman BA
Title The role of hedgehog signalling in skeletal health and disease.
Journal Reference Authors Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
Title Hedgehog and Resident Vascular Stem Cell Fate.
Journal Reference Authors Sasai N, Briscoe J
Title Primary cilia and graded Sonic Hedgehog signaling.
Journal Reference Authors Heretsch P, Tzagkaroulaki L, Giannis A
Title Modulators of the hedgehog signaling pathway.
Journal Reference Authors Anderson E, Peluso S, Lettice LA, Hill RE
Title Human limb abnormalities caused by disruption of hedgehog signaling.
Journal Reference Authors Rohatgi R, Scott MP
Title Cell biology. Arrestin' movement in cilia.
Journal Reference Authors Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
Title Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
Journal Reference Authors Ok CY, Singh RR, Vega F
Title Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
Journal Reference Authors Hsia EY, Gui Y, Zheng X
Title Regulation of Hedgehog signaling by ubiquitination.
Journal Reference Authors Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
Title CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Journal Reference Authors Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R
Title EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
Journal Reference Authors Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW
Title Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.
Journal Related KO pathway
