KEGG   PATHWAY: pgig03013
Entry
pgig03013                   Pathway                                
Name
Nucleocytoplasmic transport - Pteropus giganteus (Indian flying fox)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pgig03013  Nucleocytoplasmic transport
pgig03013

Other DBs
GO: 0050658
Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120602179  AAAS; aladin isoform X1 [KO:K14320]
120602341  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
120601700  GLE1; nucleoporin GLE1 [KO:K18723]
120595341  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
120596596  ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
120603860  RAE1; mRNA export factor [KO:K14298]
120590285  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
120602715  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
120607891  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
120594537  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
120602965  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
120620211  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
120584399  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
120587542  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
120588982  LOW QUALITY PROTEIN: small ubiquitin-related modifier 2-like [KO:K12160]
120600271  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
120607547  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
120600264  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
120605041  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
120592644  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
120589376  NUP43; nucleoporin Nup43 [KO:K14305]
120614958  NUP37; nucleoporin Nup37 [KO:K14302]
120619103  AHCTF1; LOW QUALITY PROTEIN: protein ELYS [KO:K25129]
120615523  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
120615750  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
120610649  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
120588225  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
120601179  NUP205; LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
120601673  NUP188; nucleoporin NUP188 isoform X1 [KO:K14311]
120586180  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
120617308  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
120597200  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
120621425  NDC1; nucleoporin NDC1 [KO:K14315]
120592171  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
120621412  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
120591819  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
120582262  nuclear envelope pore membrane protein POM 121C-like isoform X1 [KO:K14316]
120606134  POM121L2; POM121-like protein 2 [KO:K14316]
120588010  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
120617550  TPR; nucleoprotein TPR [KO:K09291]
120602885  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
120605582  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
120592962  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
120586698  KPNA1; importin subunit alpha-5 [KO:K23940]
120616690  KPNA7; importin subunit alpha-8 [KO:K15043]
120599963  KPNA2; importin subunit alpha-1 [KO:K15043]
120589338  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
120583863  KPNA3; importin subunit alpha-4 [KO:K23583]
120598562  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
120581989  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
120608971  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
120611229  KPNB1; importin subunit beta-1 [KO:K14293]
120608270  TNPO1; transportin-1 isoform X1 [KO:K18752]
120618541  TNPO2; transportin-2 isoform X1 [KO:K18727]
120601201  TNPO3; transportin-3 isoform X1 [KO:K15436]
120608505  IPO4; importin-4 isoform X1 [KO:K20221]
120591611  IPO5; importin-5 [KO:K20222]
120603179  IPO7; importin-7 isoform X1 [KO:K20223]
120618306  IPO8; importin-8 [KO:K18755]
120619272  IPO9; importin-9 [KO:K20224]
120608222  IPO11; importin-11 isoform X1 [KO:K25201]
120619443  IPO13; importin-13 [KO:K25202]
120597923  SNUPN; snurportin-1 [KO:K13151]
120621607  XPO1; exportin-1 isoform X1 [KO:K14290]
120603773  CSE1L; exportin-2 [KO:K18423]
120605012  XPOT; exportin-T isoform X1 [KO:K14288]
120602883  XPO4; LOW QUALITY PROTEIN: exportin-4 [KO:K25203]
120596120  XPO5; exportin-5 [KO:K14289]
120620150  XPO6; exportin-6 isoform X1 [KO:K25204]
120606612  XPO7; exportin-7 isoform X1 [KO:K18460]
120614821  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
120615984  RAN; GTP-binding nuclear protein Ran [KO:K07936]
120603935  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
120595001  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
120598336  LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like [KO:K03231]
120590906  PHAX; phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
120597590  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
120592836  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
120616374  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
120598528  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
120594996  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
120621410  MAGOH; protein mago nashi homolog [KO:K12877]
120611176  CASC3; protein CASC3 [KO:K14323]
120600101  EIF4A3; eukaryotic initiation factor 4A-III isoform X1 [KO:K13025] [EC:5.6.2.7]
120593648  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
120602923  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
120620264  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
120597778  PNN; pinin [KO:K13114]
120600209  THO complex subunit 4 [KO:K12881]
120600210  THO complex subunit 4 [KO:K12881]
120606574  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
120614596  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
120615601  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
120586038  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
120586014  nuclear RNA export factor 2-like [KO:K14284]
120589522  nuclear RNA export factor 2-like [KO:K14284]
120600831  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
120598056  NXF3; nuclear RNA export factor 3 [KO:K14284]
120616364  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
120587000  NXT1; NTF2-related export protein 1 [KO:K14285]
120618945  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
120596240  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
120604890  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
120587805  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
120612222  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
120601982  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
120620298  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
120616985  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
120615340  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pgig03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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