KEGG   PATHWAY: phei00260
Entry
phei00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Providencia heimbachae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
phei00260  Glycine, serine and threonine metabolism
phei00260

Module
phei_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:phei00260]
phei_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:phei00260]
phei_M00555  Betaine biosynthesis, choline => betaine [PATH:phei00260]
phei_M00621  Glycine cleavage system [PATH:phei00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Providencia heimbachae [GN:phei]
Gene
NCTC12003_00438  lysC; Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
NCTC12003_00664  thrA; Aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
NCTC12003_03838  metL; Aspartokinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
NCTC12003_00007  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NCTC12003_00665  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
NCTC12003_00666  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
NCTC12003_02043  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NCTC12003_01435  glyA; Pyridoxal-phosphate-dependent serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCTC12003_03525  hprA; Glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
NCTC12003_02196  ghrA; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NCTC12003_03476  ghrB; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
NCTC12003_03326  glxK_1; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
NCTC12003_03520  glxK_2; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
NCTC12003_02910  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
NCTC12003_00658  cobC; Alpha-ribazole phosphatase [KO:K15634] [EC:5.4.2.11]
NCTC12003_01285  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCTC12003_02756  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
NCTC12003_00649  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
NCTC12003_01968  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NCTC12003_03902  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
NCTC12003_03901  tdh_3; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
NCTC12003_01295  gcvP; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
NCTC12003_01293  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
NCTC12003_01269  lpdA; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCTC12003_01294  gcvH; Glycine cleavage system H protein [KO:K02437]
NCTC12003_03016  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
NCTC12003_02529  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
NCTC12003_02530  betB_2; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NCTC12003_01846  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
NCTC12003_02817  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
NCTC12003_03747  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
NCTC12003_03480  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
NCTC12003_02254  ygeA; putative racemase [KO:K25316] [EC:5.1.1.10]
NCTC12003_01837  alr_2; Alanine racemase [KO:K25317] [EC:5.1.1.10]
NCTC12003_01915  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
NCTC12003_01916  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
phei00010  Glycolysis / Gluconeogenesis
phei00020  Citrate cycle (TCA cycle)
phei00230  Purine metabolism
phei00250  Alanine, aspartate and glutamate metabolism
phei00270  Cysteine and methionine metabolism
phei00290  Valine, leucine and isoleucine biosynthesis
phei00300  Lysine biosynthesis
phei00330  Arginine and proline metabolism
phei00460  Cyanoamino acid metabolism
phei00470  D-Amino acid metabolism
phei00564  Glycerophospholipid metabolism
phei00620  Pyruvate metabolism
phei00630  Glyoxylate and dicarboxylate metabolism
phei00640  Propanoate metabolism
phei00680  Methane metabolism
phei00860  Porphyrin metabolism
phei00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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