KEGG   PATHWAY: plop04721
Entry
plop04721                   Pathway                                
Name
Synaptic vesicle cycle - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
plop04721  Synaptic vesicle cycle
plop04721

Other DBs
GO: 0016079 0048488
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125338588  Ap2a1; AP-2 complex subunit alpha-1 [KO:K11824]
125338617  Slc17a7; vesicular glutamate transporter 1 isoform X1 [KO:K12302]
125338766  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
125339504  Slc18a1; chromaffin granule amine transporter [KO:K08155]
125339695  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
125340007  Slc6a7; LOW QUALITY PROTEIN: sodium-dependent proline transporter [KO:K05040]
125340321  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
125340336  Stx1b; syntaxin-1B isoform X1 [KO:K08486]
125340860  Unc13c; protein unc-13 homolog C [KO:K15293]
125341484  Clta; clathrin light chain A [KO:K04644]
125342146  Cplx2; complexin-2 [KO:K15294]
125342183  Cltb; clathrin light chain B [KO:K04645]
125342226  Atp6v0e1; V-type proton ATPase subunit e 1 isoform X1 [KO:K02153]
125342719  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
125342890  Slc6a13; LOW QUALITY PROTEIN: sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
125343520  [KO:K02146]
125345044  Slc18a3; vesicular acetylcholine transporter [KO:K14636]
125346013  Slc18a2; synaptic vesicular amine transporter [KO:K08155]
125347058  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
125347115  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
125347191  Atp6v0a4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
125347303  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
125347960  Unc13a; protein unc-13 homolog A isoform X1 [KO:K15293]
125348724  Dnm2; dynamin-2 isoform X1 [KO:K23484]
125348843  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
125348865  Slc1a6; excitatory amino acid transporter 4 isoform X1 [KO:K05617]
125348918  Rab3a; ras-related protein Rab-3A [KO:K07882]
125349200  Atp6v0a2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
125349227  Stx2; syntaxin-2 isoform X1 [KO:K08486]
125349296  Stxbp1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
125349549  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
125351701  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
125352032  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
125352055  Ap2m1; AP-2 complex subunit mu [KO:K11826]
125352370  Slc32a1; vesicular inhibitory amino acid transporter [KO:K15015]
125352821  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
125353263  Snap25; synaptosomal-associated protein 25 [KO:K18211]
125354301  Slc1a7; excitatory amino acid transporter 5 [KO:K05618]
125355046  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
125355048  Slc6a9; sodium- and chloride-dependent glycine transporter 1 [KO:K05038]
125356310  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
125356732  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
125356904  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
125357176  Rims1; LOW QUALITY PROTEIN: regulating synaptic membrane exocytosis protein 1 [KO:K15291]
125358135  Slc6a11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
125358136  Slc6a1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
125358293  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
125358440  Slc6a2; sodium-dependent noradrenaline transporter [KO:K05035]
125358744  Slc1a1; excitatory amino acid transporter 3 [KO:K05612]
125359245  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
125359659  Slc17a8; vesicular glutamate transporter 3 isoform X1 [KO:K12302]
125359760  [KO:K11826]
125360255  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
125360434  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
125360442  Atp6v0d2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
125360506  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
125360931  Syt1; synaptotagmin-1 isoform X1 [KO:K15290]
125361230  Stx3; syntaxin-3 isoform X1 [KO:K08486]
125361311  Tcirg1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
125361368  Slc1a2; excitatory amino acid transporter 2 [KO:K05613]
125361405  Slc17a6; vesicular glutamate transporter 2 isoform X1 [KO:K12302]
125361465  Slc6a5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
125362746  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
125363222  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
125364168  Cplx4; complexin-4 [KO:K15295]
125364478  Cplx1; complexin-1 [KO:K15294]
125364758  [KO:K02152]
125365860  Vamp2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504]
125365908  Slc6a4; sodium-dependent serotonin transporter [KO:K05037]
125366135  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
125366451  Ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
125366516  Nsf; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
125366546  Atp6v0a1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
125367605  Slc1a3; excitatory amino acid transporter 1 isoform X1 [KO:K05614]
125367624  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
125367895  Napa; alpha-soluble NSF attachment protein [KO:K15296]
125368288  Stx1a; syntaxin-1A isoform X1 [KO:K04560]
125368500  Cplx3; complexin-3 [KO:K15295]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
plop04144  Endocytosis
plop04724  Glutamatergic synapse
plop04725  Cholinergic synapse
plop04726  Serotonergic synapse
plop04727  GABAergic synapse
plop04728  Dopaminergic synapse
KO pathway
ko04721   

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