KEGG   PATHWAY: pmam00260
Entry
pmam00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas maumuensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pmam00260  Glycine, serine and threonine metabolism
pmam00260

Module
pmam_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pmam00260]
pmam_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pmam00260]
pmam_M00555  Betaine biosynthesis, choline => betaine [PATH:pmam00260]
pmam_M00621  Glycine cleavage system [PATH:pmam00260]
pmam_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pmam00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas maumuensis [GN:pmam]
Gene
KSS90_07655  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KSS90_18340  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KSS90_05890  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KSS90_00365  homoserine kinase [KO:K02204] [EC:2.7.1.39]
KSS90_05895  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KSS90_01745  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KSS90_01750  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KSS90_04050  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KSS90_04570  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
KSS90_04705  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KSS90_14880  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KSS90_08290  glycerate kinase [KO:K11529] [EC:2.7.1.165]
KSS90_23650  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
KSS90_01315  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KSS90_19160  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
KSS90_22910  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
KSS90_12755  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KSS90_15590  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KSS90_15635  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KSS90_23265  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KSS90_01090  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KSS90_05455  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KSS90_01080  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KSS90_05445  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KSS90_07890  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS90_08790  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS90_25300  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS90_01085  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KSS90_05460  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KSS90_22105  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KSS90_23705  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KSS90_04260  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
KSS90_23700  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KSS90_01705  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
KSS90_01710  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
KSS90_01665  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
KSS90_01670  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
KSS90_01675  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
KSS90_01680  electron transfer flavoprotein subunit beta [KO:K25961]
KSS90_15415  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
KSS90_01765  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
KSS90_01755  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
KSS90_01770  sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
KSS90_01760  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
KSS90_06685  PLP-dependent aspartate aminotransferase family protein [KO:K01758] [EC:4.4.1.1]
KSS90_13865  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KSS90_01600  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KSS90_05450  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KSS90_13990  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
KSS90_01345  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
KSS90_07205  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KSS90_11085  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KSS90_00170  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KSS90_00175  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KSS90_14230  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
KSS90_08660  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pmam00010  Glycolysis / Gluconeogenesis
pmam00020  Citrate cycle (TCA cycle)
pmam00230  Purine metabolism
pmam00250  Alanine, aspartate and glutamate metabolism
pmam00270  Cysteine and methionine metabolism
pmam00290  Valine, leucine and isoleucine biosynthesis
pmam00300  Lysine biosynthesis
pmam00330  Arginine and proline metabolism
pmam00460  Cyanoamino acid metabolism
pmam00470  D-Amino acid metabolism
pmam00564  Glycerophospholipid metabolism
pmam00620  Pyruvate metabolism
pmam00630  Glyoxylate and dicarboxylate metabolism
pmam00640  Propanoate metabolism
pmam00680  Methane metabolism
pmam00860  Porphyrin metabolism
pmam00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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