KEGG   PATHWAY: pseh00260
Entry
pseh00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudonocardia sp. HH130629-09
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pseh00260  Glycine, serine and threonine metabolism
pseh00260

Module
pseh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pseh00260]
pseh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pseh00260]
pseh_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:pseh00260]
pseh_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pseh00260]
pseh_M00555  Betaine biosynthesis, choline => betaine [PATH:pseh00260]
pseh_M00621  Glycine cleavage system [PATH:pseh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudonocardia sp. HH130629-09 [GN:pseh]
Gene
XF36_23325  aspartate kinase [KO:K00928] [EC:2.7.2.4]
XF36_23320  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
XF36_19490  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
XF36_19480  serine kinase [KO:K00872] [EC:2.7.1.39]
XF36_16860  threonine synthase [KO:K01733] [EC:4.2.3.1]
XF36_08350  threonine synthase [KO:K01733] [EC:4.2.3.1]
XF36_19485  threonine synthase [KO:K01733] [EC:4.2.3.1]
XF36_22960  threonine aldolase [KO:K01620] [EC:4.1.2.48]
XF36_26650  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
XF36_19450  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
XF36_07780  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
XF36_13180  glycerate kinase [KO:K00865] [EC:2.7.1.165]
XF36_08840  hypothetical protein [KO:K00865] [EC:2.7.1.165]
XF36_00390  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
XF36_28290  hypothetical protein [KO:K01834] [EC:5.4.2.11]
XF36_15305  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
XF36_18830  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
XF36_10970  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
XF36_22160  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
XF36_03480  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
XF36_16920  amino acid oxidase [KO:K00274] [EC:1.4.3.4]
XF36_10725  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
XF36_08800  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
XF36_10375  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
XF36_08770  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
XF36_10695  hypothetical protein [KO:K02437]
XF36_00345  amino acid oxidase [KO:K00273] [EC:1.4.3.3]
XF36_27975  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
XF36_14805  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
XF36_16415  choline oxidase [KO:K17755] [EC:1.1.3.17]
XF36_16425  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
XF36_12285  hypothetical protein [KO:K00301] [EC:1.5.3.1]
XF36_20675  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
XF36_18705  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
XF36_02065  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
XF36_20660  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
XF36_04175  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
XF36_23820  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
XF36_23825  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
XF36_11210  tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
XF36_27780  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
XF36_27775  2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
XF36_27785  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pseh00010  Glycolysis / Gluconeogenesis
pseh00020  Citrate cycle (TCA cycle)
pseh00230  Purine metabolism
pseh00250  Alanine, aspartate and glutamate metabolism
pseh00270  Cysteine and methionine metabolism
pseh00290  Valine, leucine and isoleucine biosynthesis
pseh00300  Lysine biosynthesis
pseh00330  Arginine and proline metabolism
pseh00460  Cyanoamino acid metabolism
pseh00470  D-Amino acid metabolism
pseh00564  Glycerophospholipid metabolism
pseh00620  Pyruvate metabolism
pseh00630  Glyoxylate and dicarboxylate metabolism
pseh00640  Propanoate metabolism
pseh00680  Methane metabolism
pseh00860  Porphyrin metabolism
pseh00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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