KEGG   PATHWAY: psom00730
Entry
psom00730                   Pathway                                
Name
Thiamine metabolism - Papaver somniferum (opium poppy)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
psom00730  Thiamine metabolism
psom00730

Module
psom_M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:psom00730]
psom_M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:psom00730]
Other DBs
GO: 0006772
Organism
Papaver somniferum (opium poppy) [GN:psom]
Gene
113321130  phosphomethylpyrimidine synthase, chloroplastic-like [KO:K03147] [EC:4.1.99.17]
113310014  phosphomethylpyrimidine synthase, chloroplastic-like [KO:K03147] [EC:4.1.99.17]
113283385  thiamine biosynthetic bifunctional enzyme TH1, chloroplastic-like isoform X1 [KO:K14153] [EC:2.7.1.49 2.7.4.7 2.5.1.3]
113356580  thiamine biosynthetic bifunctional enzyme TH1, chloroplastic-like [KO:K14153] [EC:2.7.1.49 2.7.4.7 2.5.1.3]
113297840  cysteine desulfurase, mitochondrial-like [KO:K04487] [EC:2.8.1.7]
113301251  cysteine desulfurase, mitochondrial-like [KO:K04487] [EC:2.8.1.7]
113346767  cysteine desulfurase, mitochondrial-like [KO:K04487] [EC:2.8.1.7]
113356966  cysteine desulfurase, mitochondrial-like [KO:K04487] [EC:2.8.1.7]
113289417  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
113341010  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
113317928  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
113297152  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
113350185  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
113355671  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
113279575  thiamine thiazole synthase 2, chloroplastic-like [KO:K03146] [EC:2.4.2.60]
113288375  thiamine thiazole synthase 2, chloroplastic-like [KO:K03146] [EC:2.4.2.60]
113284440  thiamine thiazole synthase 2, chloroplastic-like [KO:K03146] [EC:2.4.2.60]
113287867  thiamine thiazole synthase 2, chloroplastic-like [KO:K03146] [EC:2.4.2.60]
113283061  hydroxyethylthiazole kinase-like [KO:K00878] [EC:2.7.1.50]
113296816  hydroxyethylthiazole kinase-like [KO:K00878] [EC:2.7.1.50]
113298798  cancer-related nucleoside-triphosphatase homolog isoform X1 [KO:K06928] [EC:3.6.1.15]
113289613  cancer-related nucleoside-triphosphatase homolog [KO:K06928] [EC:3.6.1.15]
113302861  small ribosomal subunit biogenesis GTPase RsgA 1, mitochondrial-like [KO:K06949] [EC:3.6.1.- 3.1.3.100]
113298110  small ribosomal subunit biogenesis GTPase RsgA 1, mitochondrial-like isoform X1 [KO:K06949] [EC:3.6.1.- 3.1.3.100]
113273941  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113301943  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113275700  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113275701  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113279180  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113303420  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113318428  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113276036  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113299743  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113276229  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113276257  bifunctional TH2 protein, mitochondrial-like isoform X1 [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113276259  bifunctional TH2 protein, mitochondrial-like isoform X1 [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113333670  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113303085  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113299564  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113302615  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113277514  bifunctional TH2 protein, mitochondrial-like [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113348098  uncharacterized protein LOC113348098 [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113352074  uncharacterized protein LOC113352074 [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113355926  bifunctional TH2 protein, mitochondrial-like isoform X1 [KO:K22911] [EC:3.1.3.100 3.5.99.-]
113336726  thiamine pyrophosphokinase 1-like [KO:K00949] [EC:2.7.6.2]
113303507  thiamine pyrophosphokinase 1-like [KO:K00949] [EC:2.7.6.2]
113318388  thiamine pyrophosphokinase 1-like [KO:K00949] [EC:2.7.6.2]
113350257  thiamine pyrophosphokinase 1-like [KO:K00949] [EC:2.7.6.2]
113318054  adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
113281488  probable adenylate kinase 7, mitochondrial [KO:K00939] [EC:2.7.4.3]
113282690  adenylate kinase 5, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
113314318  adenylate kinase 1, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
113322447  adenylate kinase 4-like [KO:K00939] [EC:2.7.4.3]
113320422  adenylate kinase 1, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
113320506  probable adenylate kinase 1, chloroplastic isoform X1 [KO:K00939] [EC:2.7.4.3]
113331538  adenylate kinase 4-like [KO:K00939] [EC:2.7.4.3]
113276567  adenylate kinase 4-like [KO:K00939] [EC:2.7.4.3]
113276584  probable adenylate kinase 7, mitochondrial [KO:K00939] [EC:2.7.4.3]
113283366  adenylate kinase, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
113277389  adenylate kinase 4-like isoform X1 [KO:K00939] [EC:2.7.4.3]
113307960  probable adenylate kinase 1, chloroplastic [KO:K00939] [EC:2.7.4.3]
113356556  adenylate kinase, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
113355935  adenylate kinase 5, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
113334507  probable bifunctional TENA-E protein [KO:K20896] [EC:3.5.1.- 3.5.99.-]
113358141  probable bifunctional TENA-E protein [KO:K20896] [EC:3.5.1.- 3.5.99.-]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
psom00010  Glycolysis / Gluconeogenesis
psom00230  Purine metabolism
psom00260  Glycine, serine and threonine metabolism
psom00270  Cysteine and methionine metabolism
psom00400  Phenylalanine, tyrosine and tryptophan biosynthesis
psom00750  Vitamin B6 metabolism
KO pathway
ko00730   
LinkDB

DBGET integrated database retrieval system