KEGG   PATHWAY: psom00260
Entry
psom00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Papaver somniferum (opium poppy)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psom00260  Glycine, serine and threonine metabolism
psom00260

Module
psom_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psom00260]
psom_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psom00260]
psom_M00555  Betaine biosynthesis, choline => betaine [PATH:psom00260]
psom_M00621  Glycine cleavage system [PATH:psom00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Papaver somniferum (opium poppy) [GN:psom]
Gene
113281164  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
113271586  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
113283419  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
113356609  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
113336911  uncharacterized protein LOC113336911 [KO:K00133] [EC:1.2.1.11]
113335221  LOW QUALITY PROTEIN: uncharacterized protein LOC113335221 [KO:K00133] [EC:1.2.1.11]
113286742  uncharacterized protein LOC113286742 [KO:K00133] [EC:1.2.1.11]
113360191  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like [KO:K00003] [EC:1.1.1.3]
113289627  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
113298935  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
113303406  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
113299571  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
113303185  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
113274784  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
113350417  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
113347671  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
113318260  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
113349918  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
113321755  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113310470  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113327789  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113339002  serine hydroxymethyltransferase 3, chloroplastic-like isoform X1 [KO:K00600] [EC:2.1.2.1]
113282885  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
113274042  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113296660  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
113290478  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113312802  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113312581  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113333776  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113328516  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
113280554  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113271654  serine hydroxymethyltransferase 2, mitochondrial-like isoform X1 [KO:K00600] [EC:2.1.2.1]
113312834  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113283239  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
113286604  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113286616  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
113302650  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113279749  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113279750  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113349445  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113353136  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113362255  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113356303  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
113361376  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113351391  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113361126  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
113313525  serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
113321704  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
113288971  glycerate dehydrogenase-like [KO:K15893] [EC:1.1.1.29]
113291123  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
113305286  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
113301760  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
113325889  uncharacterized protein LOC113325889 [KO:K01834] [EC:5.4.2.11]
113286889  uncharacterized protein LOC113286889 [KO:K01834] [EC:5.4.2.11]
113308464  metal-independent phosphoserine phosphatase-like [KO:K15634] [EC:5.4.2.11]
113289458  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
113296597  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
113323596  metal-independent phosphoserine phosphatase-like [KO:K15634] [EC:5.4.2.11]
113314039  metal-independent phosphoserine phosphatase-like [KO:K15634] [EC:5.4.2.11]
113320339  metal-independent phosphoserine phosphatase-like [KO:K15634] [EC:5.4.2.11]
113323051  metal-independent phosphoserine phosphatase-like [KO:K15634] [EC:5.4.2.11]
113320138  metal-independent phosphoserine phosphatase-like [KO:K15634] [EC:5.4.2.11]
113313513  metal-independent phosphoserine phosphatase-like [KO:K15634] [EC:5.4.2.11]
113322372  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
113308696  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
113349030  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
113348325  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
113346715  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113297739  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113301320  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113356879  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
113298868  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
113313445  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
113280986  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
113271719  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
113344052  uncharacterized protein LOC113344052 [KO:K00276] [EC:1.4.3.21]
113347115  primary amine oxidase 1-like [KO:K00276] [EC:1.4.3.21]
113346310  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
113282356  uncharacterized protein LOC113282356 [KO:K00276] [EC:1.4.3.21]
113296430  primary amine oxidase 1-like [KO:K00276] [EC:1.4.3.21]
113304618  uncharacterized protein LOC113304618 [KO:K00276] [EC:1.4.3.21]
113340990  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
113275136  uncharacterized protein LOC113275136 [KO:K00276] [EC:1.4.3.21]
113305321  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
113317514  uncharacterized protein LOC113317514 isoform X1 [KO:K00276] [EC:1.4.3.21]
113335942  uncharacterized protein LOC113335942 [KO:K00276] [EC:1.4.3.21]
113276172  uncharacterized protein LOC113276172 isoform X1 [KO:K00276] [EC:1.4.3.21]
113275220  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
113275222  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
113305398  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
113350725  primary amine oxidase 2-like [KO:K00276] [EC:1.4.3.21]
113347879  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
113349499  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
113303865  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
113287980  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
113347002  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
113333129  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
113334818  dihydrolipoyl dehydrogenase 2, chloroplastic-like isoform X1 [KO:K00382] [EC:1.8.1.4]
113358155  dihydrolipoyl dehydrogenase 2, chloroplastic-like isoform X1 [KO:K00382] [EC:1.8.1.4]
113322311  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
113288335  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
113345808  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
113290122  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
113312771  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
113279389  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
113331955  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113283771  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113357789  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
113288598  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
113318436  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
113287399  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
113299379  choline monooxygenase, chloroplastic-like isoform X1 [KO:K00499] [EC:1.14.15.7]
113358627  choline monooxygenase, chloroplastic-like isoform X1 [KO:K00499] [EC:1.14.15.7]
113323772  betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
113313674  betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
113272418  betaine aldehyde dehydrogenase 2, mitochondrial-like [KO:K00130] [EC:1.2.1.8]
113276374  betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
113343708  betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
113328159  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
113337233  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
113298882  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
113358661  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
113309864  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
113298749  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
113338803  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
113310303  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
113299299  serine racemase-like isoform X1 [KO:K12235] [EC:5.1.1.18]
113362076  serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
113318688  tryptophan synthase alpha chain-like isoform X1 [KO:K01695] [EC:4.2.1.20]
113342470  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
113278123  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
113360269  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
113350029  tryptophan synthase alpha chain isoform X1 [KO:K01695] [EC:4.2.1.20]
113353083  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
113318420  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
113348705  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
113336746  uncharacterized protein LOC113336746 [KO:K06001] [EC:4.2.1.20]
113273926  uncharacterized protein LOC113273926 [KO:K06001] [EC:4.2.1.20]
113281933  uncharacterized protein LOC113281933 [KO:K06001] [EC:4.2.1.20]
113284019  uncharacterized protein LOC113284019 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psom00010  Glycolysis / Gluconeogenesis
psom00020  Citrate cycle (TCA cycle)
psom00230  Purine metabolism
psom00250  Alanine, aspartate and glutamate metabolism
psom00270  Cysteine and methionine metabolism
psom00290  Valine, leucine and isoleucine biosynthesis
psom00300  Lysine biosynthesis
psom00330  Arginine and proline metabolism
psom00460  Cyanoamino acid metabolism
psom00470  D-Amino acid metabolism
psom00564  Glycerophospholipid metabolism
psom00600  Sphingolipid metabolism
psom00620  Pyruvate metabolism
psom00630  Glyoxylate and dicarboxylate metabolism
psom00640  Propanoate metabolism
psom00860  Porphyrin metabolism
psom00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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