KEGG   PATHWAY: pvp04390
Entry
pvp04390                    Pathway                                
Name
Hippo signaling pathway - Pteropus vampyrus (large flying fox)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
pvp04390  Hippo signaling pathway
pvp04390

Other DBs
GO: 0035329
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288320  [KO:K08960] [EC:2.7.11.1]
105288434  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105288886  DLG5; disks large homolog 5 isoform X1 [KO:K24050]
105288917  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
105289220  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105289435  LATS1; serine/threonine-protein kinase LATS1 [KO:K08791] [EC:2.7.11.1]
105289544  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
105289942  WWC1; protein KIBRA [KO:K16685]
105290156  WNT16; protein Wnt-16 [KO:K01558]
105290328  CTNNB1; catenin beta-1 [KO:K02105]
105290379  LIMD1; LIM domain-containing protein 1 [KO:K16682]
105290434  WNT4; protein Wnt-4 [KO:K00408]
105290711  CTNNA2; catenin alpha-2 isoform X1 [KO:K05691]
105290745  MOB1A; MOB kinase activator 1A isoform X1 [KO:K06685]
105291051  WNT10A; protein Wnt-10a [KO:K01357]
105291052  WNT6; protein Wnt-6 isoform X2 [KO:K00445]
105291129  CTGF; connective tissue growth factor [KO:K06827]
105291325  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
105291480  TCF7L2; transcription factor 7-like 2 isoform X8 [KO:K04491]
105291512  FZD3; frizzled-3 isoform X1 [KO:K02329]
105291557  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
105291733  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105291735  DLG4; disks large homolog 4 isoform X3 [KO:K11828]
105291867  YWHAE; 14-3-3 protein epsilon [KO:K06630]
105292086  NKD1; protein naked cuticle homolog 1 [KO:K03213]
105292147  LATS2; serine/threonine-protein kinase LATS2 [KO:K08791] [EC:2.7.11.1]
105292175  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105292297  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
105292337  AFP; alpha-fetoprotein [KO:K16144]
105292347  AREG; amphiregulin [KO:K09782]
105292405  MOB1B; MOB kinase activator 1B [KO:K06685]
105292412  [KO:K16144]
105292413  RASSF6; ras association domain-containing protein 6 [KO:K09854]
105292451  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105292561  MYC; myc proto-oncogene protein [KO:K04377]
105292575  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
105292617  TP53BP2; apoptosis-stimulating of p53 protein 2 [KO:K16823]
105292640  SMAD2; mothers against decapentaplegic homolog 2 isoform X3 [KO:K04500]
105293004  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105293400  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
105293422  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
105293567  TCF7; transcription factor 7 isoform X2 [KO:K02620]
105293570  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105293607  WNT8A; protein Wnt-8a [KO:K00714]
105294187  FZD4; frizzled-4 [KO:K02354]
105294207  DLG2; disks large homolog 2 [KO:K12075]
105294458  GLI2; zinc finger protein GLI2 [KO:K16798]
105294552  FZD1; frizzled-1 [KO:K02432]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105294900  CRB2; protein crumbs homolog 2 [KO:K16681]
105294978  WNT7A; protein Wnt-7a [KO:K00572]
105295145  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
105295433  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
105295478  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
105295648  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105296048  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
105296163  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105296245  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105296814  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105296929  CRB1; protein crumbs homolog 1 [KO:K16681]
105297044  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105297060  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
105297256  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105297278  TEAD4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448]
105297315  BBC3; bcl-2-binding component 3 [KO:K10132]
105297527  WNT10B; protein Wnt-10b [KO:K01357]
105297529  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105297627  WNT11; protein Wnt-11 [KO:K01384]
105297749  AXIN2; axin-2 [KO:K04385]
105298112  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
105298116  FZD7; frizzled-7 [KO:K02432]
105298225  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105298276  YAP1; transcriptional coactivator YAP1 isoform X1 [KO:K16687]
105298277  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105298278  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105298343  PATJ; inaD-like protein [KO:K06092]
105298400  FZD5; frizzled-5 [KO:K02375]
105298541  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
105298720  BMP2; bone morphogenetic protein 2 [KO:K21283]
105298780  BMP7; bone morphogenetic protein 7 [KO:K16621]
105299132  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105299201  TP73; tumor protein p73 [KO:K10148]
105299206  TGFB3; transforming growth factor beta-3 [KO:K13377]
105299298  FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
105299568  FZD10; frizzled-10 [KO:K02842]
105299684  FZD9; frizzled-9 [KO:K02842]
105299698  YWHAG; 14-3-3 protein gamma [KO:K16198]
105299725  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
105299863  WNT5A; protein Wnt-5a isoform X5 [KO:K00444]
105299958  WNT3A; protein Wnt-3a [KO:K00312]
105299964  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105300002  WNT9A; protein Wnt-9a [KO:K01064]
105300077  SNAI2; zinc finger protein SNAI2 [KO:K05706]
105300459  AMH; muellerian-inhibiting factor [KO:K04665]
105300527  AJUBA; LIM domain-containing protein ajuba isoform X1 [KO:K16682]
105300596  GDF6; growth/differentiation factor 6 [KO:K20012]
105300612  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
105300873  FZD6; frizzled-6 isoform X1 [KO:K02376]
105300925  NF2; merlin isoform X2 [KO:K16684]
105301028  TEAD3; transcriptional enhancer factor TEF-5 [KO:K09448]
105301125  CSNK1D; casein kinase I isoform X2 [KO:K08959] [EC:2.7.11.1]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105301317  NKD2; LOW QUALITY PROTEIN: protein naked cuticle homolog 2 [KO:K03213]
105301474  TEAD1; transcriptional enhancer factor TEF-1 isoform X7 [KO:K09448]
105301606  AMOT; angiomotin isoform X1 [KO:K16819]
105301701  CTNNA3; catenin alpha-3 [KO:K05691]
105301748  TEAD2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
105302012  SCRIB; protein scribble homolog [KO:K16175]
105302044  WNT7B; protein Wnt-7b [KO:K00572]
105302075  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
105302259  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105302907  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105303015  PARD3; partitioning defective 3 homolog [KO:K04237]
105303028  ITGB2; integrin beta-2 [KO:K06464]
105303252  AXIN1; axin-1 isoform X1 [KO:K02157]
105303453  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105303454  WNT9B; protein Wnt-9b [KO:K01064]
105303480  FZD2; frizzled-2 [KO:K02235]
105303599  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
105303610  PRKCZ; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
105303713  FRMD1; FERM domain-containing protein 1 [KO:K16821]
105304340  GDF5; growth/differentiation factor 5 [KO:K04664]
105304489  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
105304642  BTRC; F-box/WD repeat-containing protein 1A isoform X3 [KO:K03362]
105304667  WNT8B; protein Wnt-8b [KO:K00714]
105305501  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
105305616  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105305725  PARD6A; partitioning defective 6 homolog alpha isoform X3 [KO:K06093]
105305756  CDH1; cadherin-1 isoform X1 [KO:K05689]
105306273  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
105306596  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
105306994  CTNNA1; catenin alpha-1 [KO:K05691]
105307126  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105307128  [KO:K04503]
105307149  FZD8; frizzled-8 [KO:K02375]
105307378  SOX2; transcription factor SOX-2 [KO:K16796]
105307945  TGFB1; transforming growth factor beta-1 [KO:K13375]
105308249  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
105308338  YWHAH; 14-3-3 protein eta [KO:K16198]
105308466  WNT2; protein Wnt-2 [KO:K00182]
105309232  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
105309396  FRMD6; FERM domain-containing protein 6 isoform X2 [KO:K16822]
105309642  WWTR1; WW domain-containing transcription regulator protein 1 [KO:K16820]
105309746  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
105309794  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105309924  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105310250  SAV1; protein salvador homolog 1 [KO:K16686]
105310465  [KO:K08959] [EC:2.7.11.1]
105311245  [KO:K16622]
Reference
PMID:22750148
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21874053
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
PMID:21084559
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:23034192
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:22658639
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:21324984
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
PMID:18955139
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
PMID:20945341
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
PMID:18328423
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
PMID:19846288
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
PMID:17975546
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
PMID:22683405
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:22895435
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
PMID:22153608
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
PMID:21376238
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
pvp04120  Ubiquitin mediated proteolysis
pvp04310  Wnt signaling pathway
pvp04350  TGF-beta signaling pathway
pvp04520  Adherens junction
pvp04530  Tight junction
KO pathway
ko04390   

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