KEGG   PATHWAY: pvp04530
Entry
pvp04530                    Pathway                                
Name
Tight junction - Pteropus vampyrus (large flying fox)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pvp04530  Tight junction
pvp04530

Other DBs
GO: 0005923
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288356  ACTR3; actin-related protein 3 [KO:K18584]
105288474  TJAP1; tight junction-associated protein 1 [KO:K06105]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289016  CLDN10; claudin-10 isoform X1 [KO:K06087]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105289211  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
105289221  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105289266  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
105289473  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105290792  CLDN8; claudin-8 [KO:K06087]
105290793  CLDN17; claudin-17 [KO:K06087]
105290833  JAM2; junctional adhesion molecule B [KO:K06735]
105290992  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8 [KO:K05631]
105291036  [KO:K07374]
105291037  [KO:K07374]
105291053  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X2 [KO:K07200]
105291072  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105291194  CLDN7; claudin-7 [KO:K06087]
105291259  MYH10; myosin-10 isoform X1 [KO:K10352]
105291325  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
105291571  GATA4; transcription factor GATA-4 [KO:K09183]
105292175  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105292284  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
105292487  BVES; blood vessel epicardial substance [KO:K21108]
105292733  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
105292973  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
105293331  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
105293422  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
105293536  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
105293561  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
105293570  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105293839  CLDN20; claudin-20 [KO:K06087]
105294207  DLG2; disks large homolog 2 [KO:K12075]
105294257  RAB8B; ras-related protein Rab-8B [KO:K07902]
105294283  CGNL1; cingulin-like protein 1 [KO:K21110]
105294291  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
105294479  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105294590  CLDN12; claudin-12 [KO:K06087]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105294731  [KO:K06087]
105294732  [KO:K06087]
105294862  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105295039  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105295355  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
105295461  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
105295572  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
105295622  CLDN25; putative claudin-25 [KO:K06087]
105295648  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105295655  RDX; radixin [KO:K05762]
105295821  CLDN14; claudin-14 [KO:K06087]
105295829  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
105296048  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
105296352  ARHGEF2; rho guanine nucleotide exchange factor 2 [KO:K12791]
105296459  RAB13; ras-related protein Rab-13 [KO:K06109]
105296470  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105296654  RAB8A; ras-related protein Rab-8A [KO:K07901]
105296850  CLDN5; claudin-5 [KO:K06087]
105296884  RAP1A; ras-related protein Rap-1A [KO:K04353]
105297060  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
105297234  TUBA8; tubulin alpha-8 chain [KO:K07374]
105297337  VASP; vasodilator-stimulated phosphoprotein isoform X6 [KO:K06274]
105297531  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
105297536  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
105297537  [KO:K07374]
105297584  [KO:K07374]
105297801  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
105298121  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
105298343  PATJ; inaD-like protein [KO:K06092]
105298997  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
105299048  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
105299096  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
105299360  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105299404  PCNA; proliferating cell nuclear antigen [KO:K04802]
105299449  SYNPO; synaptopodin [KO:K21112]
105299674  CLDN4; claudin-4 [KO:K06087]
105299675  CLDN3; claudin-3 [KO:K06087]
105299717  CLDN15; claudin-15 [KO:K06087]
105299756  CLDN23; claudin-23 [KO:K06087]
105299964  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105300126  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
105300184  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105300481  TJP3; tight junction protein ZO-3 [KO:K06097]
105300506  OCLN; occludin [KO:K06088]
105300559  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
105300830  CLDN18; claudin-18 isoform X1 [KO:K06087]
105300925  NF2; merlin isoform X2 [KO:K16684]
105301105  CRB3; protein crumbs homolog 3 [KO:K06090]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105301274  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105301606  AMOT; angiomotin isoform X1 [KO:K16819]
105301782  MYH14; myosin-14 [KO:K10352]
105301904  AMOTL1; angiomotin-like protein 1 [KO:K06104]
105302012  SCRIB; protein scribble homolog [KO:K16175]
105302230  STK11; LOW QUALITY PROTEIN: serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
105302327  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105302468  ARHGAP17; rho GTPase-activating protein 17 [KO:K20638]
105302587  MYL6B; myosin light chain 6B [KO:K12751]
105302588  MYL6; myosin light polypeptide 6 isoform X2 [KO:K12751]
105302890  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
105302930  JAM3; LOW QUALITY PROTEIN: junctional adhesion molecule C [KO:K06785]
105302989  EZR; ezrin [KO:K08007]
105303008  ITGB1; integrin beta-1 [KO:K05719]
105303015  PARD3; partitioning defective 3 homolog [KO:K04237]
105303127  CLDN6; claudin-6 [KO:K06087]
105303128  CLDN9; claudin-9 [KO:K06087]
105303417  F11R; junctional adhesion molecule A [KO:K06089]
105303436  JUN; transcription factor AP-1 [KO:K04448]
105303610  PRKCZ; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
105303711  AFDN; afadin [KO:K05702]
105303767  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105303778  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
105303844  CGN; cingulin [KO:K06102]
105304024  CLDN19; claudin-19 [KO:K06087]
105304363  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105304440  [KO:K07839]
105304472  MICALL2; MICAL-like protein 2 [KO:K21068]
105304489  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
105305242  [KO:K12757]
105305243  [KO:K12757]
105305616  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105305637  CLDN11; claudin-11 [KO:K06087]
105305725  PARD6A; partitioning defective 6 homolog alpha isoform X3 [KO:K06093]
105305843  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
105306059  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
105306069  CLDN2; claudin-2 [KO:K06087]
105306273  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
105306499  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
105306596  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
105306687  ACTR2; actin-related protein 2 [KO:K17260]
105306878  [KO:K06448]
105306881  [KO:K06448]
105307128  [KO:K04503]
105307130  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
105307393  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
105307437  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
105307472  CTTN; src substrate cortactin [KO:K06106]
105307498  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105307700  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105307771  MSN; moesin [KO:K05763]
105307790  CLDN1; claudin-1 [KO:K06087]
105307985  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
105308049  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105308107  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
105308249  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
105308468  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105308891  [KO:K06099]
105309151  TJP1; tight junction protein ZO-1 [KO:K05701]
105309299  [KO:K06448]
105309300  [KO:K06448]
105309437  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105309438  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105309794  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105309929  [KO:K06099]
105310012  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
105310225  [KO:K06099]
105310602  [KO:K06087]
105311088  [KO:K06090]
105311327  MYH9; myosin-9 isoform X1 [KO:K10352]
105311568  CLDN34; claudin-34 [KO:K06087]
111728742  SYMPK; symplekin [KO:K06100]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
pvp04520  Adherens junction
pvp04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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