KEGG   PATHWAY: rrho00260
Entry
rrho00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium rhododendri
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rrho00260  Glycine, serine and threonine metabolism
rrho00260

Module
rrho_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rrho00260]
rrho_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rrho00260]
rrho_M00555  Betaine biosynthesis, choline => betaine [PATH:rrho00260]
rrho_M00621  Glycine cleavage system [PATH:rrho00260]
rrho_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:rrho00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium rhododendri [GN:rrho]
Gene
PR018_13690  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PR018_15465  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PR018_07985  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PR018_02320  homoserine kinase [KO:K02204] [EC:2.7.1.39]
PR018_02375  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PR018_12005  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PR018_04415  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PR018_23770  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PR018_27365  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PR018_11355  glycerate kinase [KO:K11529] [EC:2.7.1.165]
PR018_03000  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
PR018_16480  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PR018_18390  NAD(P)-dependent oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PR018_23670  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PR018_23675  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
PR018_08775  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
PR018_14215  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
PR018_28350  NAD(P)/FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
PR018_07150  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PR018_07140  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
PR018_16705  aminomethyltransferase family protein [KO:K00605] [EC:2.1.2.10]
PR018_16840  DUF1989 domain-containing protein [KO:K00605] [EC:2.1.2.10]
PR018_06160  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PR018_14325  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PR018_07145  gcvH; glycine cleavage system protein GcvH [KO:K02437]
PR018_03925  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
PR018_02770  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PR018_02785  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PR018_02080  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
PR018_02085  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
PR018_10905  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
PR018_18620  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
PR018_28090  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
PR018_12180  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PR018_12190  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PR018_12175  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PR018_12185  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PR018_07005  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
PR018_05770  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
PR018_11810  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
PR018_15725  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
PR018_15720  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rrho00010  Glycolysis / Gluconeogenesis
rrho00020  Citrate cycle (TCA cycle)
rrho00230  Purine metabolism
rrho00250  Alanine, aspartate and glutamate metabolism
rrho00270  Cysteine and methionine metabolism
rrho00290  Valine, leucine and isoleucine biosynthesis
rrho00300  Lysine biosynthesis
rrho00330  Arginine and proline metabolism
rrho00460  Cyanoamino acid metabolism
rrho00470  D-Amino acid metabolism
rrho00564  Glycerophospholipid metabolism
rrho00600  Sphingolipid metabolism
rrho00620  Pyruvate metabolism
rrho00630  Glyoxylate and dicarboxylate metabolism
rrho00640  Propanoate metabolism
rrho00680  Methane metabolism
rrho00860  Porphyrin metabolism
rrho00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system