KEGG   PATHWAY: sale00260
Entry
sale00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Salicibibacter halophilus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sale00260  Glycine, serine and threonine metabolism
sale00260

Module
sale_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sale00260]
sale_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sale00260]
sale_M00555  Betaine biosynthesis, choline => betaine [PATH:sale00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salicibibacter halophilus [GN:sale]
Gene
EPH95_02600  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
EPH95_05050  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EPH95_02605  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EPH95_01500  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EPH95_09095  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EPH95_09085  homoserine kinase [KO:K00872] [EC:2.7.1.39]
EPH95_09090  threonine synthase [KO:K01733] [EC:4.2.3.1]
EPH95_11715  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EPH95_07190  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EPH95_16925  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EPH95_16780  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
EPH95_12445  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
EPH95_17840  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
EPH95_01585  HAD family hydrolase [KO:K25528] [EC:3.1.3.3]
EPH95_00545  aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
EPH95_00540  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EPH95_05205  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EPH95_00750  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EPH95_09305  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EPH95_07840  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EPH95_15005  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EPH95_13605  iron-containing alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
EPH95_15000  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EPH95_07880  N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
EPH95_09820  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
EPH95_01420  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EPH95_02065  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
EPH95_07835  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
EPH95_01240  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EPH95_01235  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EPH95_17405  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
EPH95_17410  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
EPH95_17400  ectoine synthase [KO:K06720] [EC:4.2.1.108]
EPH95_17035  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
EPH95_10530  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
EPH95_13645  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
EPH95_01510  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sale00010  Glycolysis / Gluconeogenesis
sale00020  Citrate cycle (TCA cycle)
sale00230  Purine metabolism
sale00250  Alanine, aspartate and glutamate metabolism
sale00270  Cysteine and methionine metabolism
sale00290  Valine, leucine and isoleucine biosynthesis
sale00300  Lysine biosynthesis
sale00330  Arginine and proline metabolism
sale00460  Cyanoamino acid metabolism
sale00470  D-Amino acid metabolism
sale00564  Glycerophospholipid metabolism
sale00600  Sphingolipid metabolism
sale00620  Pyruvate metabolism
sale00630  Glyoxylate and dicarboxylate metabolism
sale00640  Propanoate metabolism
sale00680  Methane metabolism
sale00860  Porphyrin metabolism
sale00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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