KEGG   PATHWAY: sce00010Help
Entry
sce00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Saccharomyces cerevisiae (budding yeast)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
sce00010  Glycolysis / Gluconeogenesis
sce00010

Ortholog table
Module
sce_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sce00010]
sce_M00002  Glycolysis, core module involving three-carbon compounds [PATH:sce00010]
sce_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sce00010]
sce_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sce00010]
Other DBs
BSID: 855
GO: 0006096 0006094
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YGL253W  HXK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]
YFR053C  HXK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]
YCL040W  GLK1; glucokinase [KO:K00844] [EC:2.7.1.1]
YDR516C  EMI2; putative glucokinase [KO:K00844] [EC:2.7.1.1]
YLR446W  hexokinase [KO:K00844] [EC:2.7.1.1]
YBR196C  PGI1; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
YMR205C  PFK2; 6-phosphofructokinase subunit beta [KO:K00850] [EC:2.7.1.11]
YGR240C  PFK1; 6-phosphofructokinase subunit alpha [KO:K00850] [EC:2.7.1.11]
YLR377C  FBP1; fructose 1,6-bisphosphate 1-phosphatase [KO:K03841] [EC:3.1.3.11]
YKL060C  FBA1; fructose-bisphosphate aldolase FBA1 [KO:K01624] [EC:4.1.2.13]
YDR050C  TPI1; triose-phosphate isomerase TPI1 [KO:K01803] [EC:5.3.1.1]
YGR192C  TDH3; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 [KO:K00134] [EC:1.2.1.12]
YJL052W  TDH1; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 [KO:K00134] [EC:1.2.1.12]
YJR009C  TDH2; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 [KO:K00134] [EC:1.2.1.12]
YCR012W  PGK1; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
YDL021W  GPM2; phosphoglycerate mutase family protein GPM2 [KO:K01834] [EC:5.4.2.11]
YKL152C  GPM1; phosphoglycerate mutase GPM1 [KO:K01834] [EC:5.4.2.11]
YOL056W  GPM3; phosphoglycerate mutase family protein GPM3 [KO:K01834] [EC:5.4.2.11]
YMR323W  ERR3; phosphopyruvate hydratase ERR3 [KO:K01689] [EC:4.2.1.11]
YGR254W  ENO1; phosphopyruvate hydratase ENO1 [KO:K01689] [EC:4.2.1.11]
YHR174W  ENO2; phosphopyruvate hydratase ENO2 [KO:K01689] [EC:4.2.1.11]
YOR393W  ERR1; phosphopyruvate hydratase ERR1 [KO:K01689] [EC:4.2.1.11]
YPL281C  ERR2; phosphopyruvate hydratase ERR2 [KO:K01689] [EC:4.2.1.11]
YAL038W  CDC19; pyruvate kinase CDC19 [KO:K00873] [EC:2.7.1.40]
YOR347C  PYK2; pyruvate kinase PYK2 [KO:K00873] [EC:2.7.1.40]
YER178W  PDA1; pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha [KO:K00161] [EC:1.2.4.1]
YBR221C  PDB1; pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [KO:K00162] [EC:1.2.4.1]
YNL071W  LAT1; dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
YPL017C  IRC15; Irc15p [KO:K00382] [EC:1.8.1.4]
YFL018C  LPD1; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
YDL080C  THI3; branched-chain-2-oxoacid decarboxylase THI3 [KO:K01568] [EC:4.1.1.1]
YGR087C  PDC6; indolepyruvate decarboxylase 6 [KO:K01568] [EC:4.1.1.1]
YLR044C  PDC1; indolepyruvate decarboxylase 1 [KO:K01568] [EC:4.1.1.1]
YLR134W  PDC5; indolepyruvate decarboxylase 5 [KO:K01568] [EC:4.1.1.1]
YDL168W  SFA1; bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase [KO:K00121] [EC:1.1.1.1 1.1.1.284]
YOL086C  ADH1; alcohol dehydrogenase ADH1 [KO:K13953] [EC:1.1.1.1]
YMR303C  ADH2; alcohol dehydrogenase ADH2 [KO:K13953] [EC:1.1.1.1]
YBR145W  ADH5; alcohol dehydrogenase ADH5 [KO:K13953] [EC:1.1.1.1]
YMR083W  ADH3; alcohol dehydrogenase ADH3 [KO:K13953] [EC:1.1.1.1]
YGL256W  ADH4; alcohol dehydrogenase ADH4 [KO:K13954] [EC:1.1.1.1]
YCR105W  ADH7; NADP-dependent alcohol dehydrogenase [KO:K00002] [EC:1.1.1.2]
YMR318C  ADH6; NADP-dependent alcohol dehydrogenase [KO:K00002] [EC:1.1.1.2]
YOR374W  ALD4; aldehyde dehydrogenase (NADP(+)) ALD4 [KO:K00128] [EC:1.2.1.3]
YPL061W  ALD6; aldehyde dehydrogenase (NADP(+)) ALD6 [KO:K00128] [EC:1.2.1.3]
YER073W  ALD5; aldehyde dehydrogenase (NAD(P)(+)) ALD5 [KO:K00128] [EC:1.2.1.3]
YMR110C  HFD1; hexadecenal dehydrogenase [KO:K00128] [EC:1.2.1.3]
YMR169C  ALD3; aldehyde dehydrogenase (NAD(+)) ALD3 [KO:K00129] [EC:1.2.1.5]
YMR170C  ALD2; aldehyde dehydrogenase (NAD(+)) ALD2 [KO:K00129] [EC:1.2.1.5]
YAL054C  ACS1; acetate--CoA ligase 1 [KO:K01895] [EC:6.2.1.1]
YLR153C  ACS2; acetate--CoA ligase ACS2 [KO:K01895] [EC:6.2.1.1]
YBR019C  GAL10; bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [KO:K01784 K01785] [EC:5.1.3.2 5.1.3.3]
YMR105C  PGM2; phosphoglucomutase PGM2 [KO:K01835] [EC:5.4.2.2]
YKL127W  PGM1; phosphoglucomutase PGM1 [KO:K01835] [EC:5.4.2.2]
YMR278W  PRM15; phosphoribomutase PRM15 [KO:K01835] [EC:5.4.2.2]
YMR099C  glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
YKR097W  PCK1; phosphoenolpyruvate carboxykinase PCK1 [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00010   
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