KEGG   PATHWAY: sce00030Help
sce00030                    Pathway                                

Pentose phosphate pathway - Saccharomyces cerevisiae (budding yeast)
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
sce00030  Pentose phosphate pathway

Ortholog table
sce_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:sce00030]
sce_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:sce00030]
sce_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:sce00030]
sce_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:sce00030]
Other DBs
BSID: 857
GO: 0006098
Saccharomyces cerevisiae (budding yeast) [GN:sce]
YBR196C  PGI1; glucose-6-phosphate isomerase [KO:K01810] [EC:]
YNL241C  ZWF1; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:]
YNR034W  SOL1; Sol1p [KO:K01057] [EC:]
YCR073W-A  SOL2; Sol2p [KO:K01057] [EC:]
YGR248W  SOL4; 6-phosphogluconolactonase SOL4 [KO:K01057] [EC:]
YHR163W  SOL3; 6-phosphogluconolactonase SOL3 [KO:K01057] [EC:]
YGR256W  GND2; phosphogluconate dehydrogenase (decarboxylating) GND2 [KO:K00033] [EC:]
YHR183W  GND1; phosphogluconate dehydrogenase (decarboxylating) GND1 [KO:K00033] [EC:]
YJL121C  RPE1; ribulose-phosphate 3-epimerase RPE1 [KO:K01783] [EC:]
YPR074C  TKL1; transketolase TKL1 [KO:K00615] [EC:]
YBR117C  TKL2; transketolase TKL2 [KO:K00615] [EC:]
YLR354C  TAL1; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [KO:K00616] [EC:]
YGR043C  NQM1; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 [KO:K00616] [EC:]
YOR095C  RKI1; ribose-5-phosphate isomerase RKI1 [KO:K01807] [EC:]
YCR036W  RBK1; putative ribokinase [KO:K00852] [EC:]
YMR105C  PGM2; phosphoglucomutase PGM2 [KO:K01835] [EC:]
YKL127W  PGM1; phosphoglucomutase PGM1 [KO:K01835] [EC:]
YMR278W  PRM15; phosphoribomutase PRM15 [KO:K01835] [EC:]
YOL061W  PRS5; ribose phosphate diphosphokinase subunit PRS5 [KO:K00948] [EC:]
YHL011C  PRS3; ribose phosphate diphosphokinase subunit PRS3 [KO:K00948] [EC:]
YER099C  PRS2; ribose phosphate diphosphokinase subunit PRS2 [KO:K00948] [EC:]
YBL068W  PRS4; ribose phosphate diphosphokinase subunit PRS4 [KO:K00948] [EC:]
YKL181W  PRS1; ribose phosphate diphosphokinase subunit PRS1 [KO:K00948] [EC:]
YDR248C  gluconokinase [KO:K00851] [EC:]
YKL060C  FBA1; fructose-bisphosphate aldolase FBA1 [KO:K01624] [EC:]
YLR377C  FBP1; fructose 1,6-bisphosphate 1-phosphatase [KO:K03841] [EC:]
YMR205C  PFK2; 6-phosphofructokinase subunit beta [KO:K00850] [EC:]
YGR240C  PFK1; 6-phosphofructokinase subunit alpha [KO:K00850] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
(map 3)
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
(map 4)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
J Bacteriol 185:2793-801 (2003)
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
J Bacteriol 188:4698-704 (2006)
Kato N, Yurimoto H, Thauer RK
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem 70:10-21 (2006)
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
FEBS J 280:1126-38 (2013)
Reher M, Schonheit P
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
FEBS Lett 580:1198-204 (2006)
Reher M, Fuhrer T, Bott M, Schonheit P
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
J Bacteriol 192:964-74 (2010)
KO pathway
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