KEGG   PATHWAY: sce00230
Entry
sce00230                    Pathway                                
Name
Purine metabolism - Saccharomyces cerevisiae (budding yeast)
Class
Metabolism; Nucleotide metabolism
Pathway map
sce00230  Purine metabolism
sce00230

Module
sce_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:sce00230]
sce_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:sce00230]
sce_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:sce00230]
sce_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:sce00230]
sce_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sce00230]
Other DBs
GO: 0006163 0042278
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YBR111C  YSA1; ADP-ribose diphosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
YMR105C  PGM2; phosphoglucomutase PGM2 [KO:K01835] [EC:5.4.2.2]
YKL127W  PGM1; phosphoglucomutase PGM1 [KO:K01835] [EC:5.4.2.2]
YMR278W  PRM15; phosphoribomutase PRM15 [KO:K01835] [EC:5.4.2.2]
YOL061W  PRS5; ribose phosphate diphosphokinase subunit PRS5 [KO:K00948] [EC:2.7.6.1]
YHL011C  PRS3; ribose phosphate diphosphokinase subunit PRS3 [KO:K00948] [EC:2.7.6.1]
YER099C  PRS2; ribose phosphate diphosphokinase subunit PRS2 [KO:K00948] [EC:2.7.6.1]
YBL068W  PRS4; ribose phosphate diphosphokinase subunit PRS4 [KO:K00948] [EC:2.7.6.1]
YKL181W  PRS1; ribose phosphate diphosphokinase subunit PRS1 [KO:K00948] [EC:2.7.6.1]
YMR300C  ADE4; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
YGL234W  ADE57; bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase [KO:K11788] [EC:6.3.4.13 6.3.3.1]
YDR408C  ADE8; phosphoribosylglycinamide formyltransferase [KO:K00601] [EC:2.1.2.2]
YGR061C  ADE6; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
YOR128C  ADE2; phosphoribosylaminoimidazole carboxylase ADE2 [KO:K11808] [EC:4.1.1.21]
YAR015W  ADE1; phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
YLR359W  ADE13; adenylosuccinase ADE13 [KO:K01756] [EC:4.3.2.2]
YMR120C  ADE17; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
YLR028C  ADE16; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
YML022W  APT1; adenine phosphoribosyltransferase APT1 [KO:K00759] [EC:2.4.2.7]
YDR441C  APT2; adenine phosphoribosyltransferase APT2 [KO:K00759] [EC:2.4.2.7]
YOR155C  ISN1; IMP 5'-nucleotidase [KO:K18550] [EC:3.1.3.99 3.1.3.-]
YLR209C  PNP1; purine-nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
YDR399W  HPT1; hypoxanthine phosphoribosyltransferase [KO:K19836] [EC:2.4.2.8]
YLR432W  IMD3; IMP dehydrogenase IMD3 [KO:K00088] [EC:1.1.1.205]
YML056C  IMD4; IMP dehydrogenase IMD4 [KO:K00088] [EC:1.1.1.205]
YHR216W  IMD2; IMP dehydrogenase IMD2 [KO:K00088] [EC:1.1.1.205]
YKL067W  YNK1; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
YER005W  YND1; apyrase [KO:K14642] [EC:3.6.1.5]
YJR069C  HAM1; nucleoside triphosphate pyrophosphohydrolase HAM1 [KO:K01519] [EC:3.6.1.66]
YMR217W  GUA1; GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
YDL238C  GUD1; guanine deaminase [KO:K01487] [EC:3.5.4.3]
YDR454C  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
YIL066C  RNR3; ribonucleotide-diphosphate reductase subunit RNR3 [KO:K10807] [EC:1.17.4.1]
YER070W  RNR1; ribonucleotide-diphosphate reductase subunit RNR1 [KO:K10807] [EC:1.17.4.1]
YJL026W  RNR2; ribonucleotide-diphosphate reductase subunit RNR2 [KO:K10808] [EC:1.17.4.1]
YGR180C  RNR4; ribonucleotide-diphosphate reductase subunit RNR4 [KO:K10808] [EC:1.17.4.1]
YBR242W  5'-deoxynucleotidase [KO:K07023] [EC:3.1.3.89]
YGL101W  YGK1; 5'-deoxynucleotidase [KO:K07023] [EC:3.1.3.89]
YHR201C  PPX1; exopolyphosphatase [KO:K01514] [EC:3.6.1.11]
YJL005W  CYR1; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
YOR360C  PDE2; 3',5'-cyclic-nucleotide phosphodiesterase PDE2 [KO:K01120] [EC:3.1.4.17]
YGL248W  PDE1; 3',5'-cyclic-nucleotide phosphodiesterase PDE1 [KO:K01120] [EC:3.1.4.17]
YNL220W  ADE12; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
YML035C  AMD1; AMP deaminase [KO:K01490] [EC:3.5.4.6]
YJR105W  ADO1; adenosine kinase [KO:K00856] [EC:2.7.1.20]
YNL141W  AAH1; adenine deaminase [KO:K21053] [EC:3.5.4.2]
YDR226W  ADK1; adenylate kinase ADK1 [KO:K00939] [EC:2.7.4.3]
YDL166C  FAP7; nucleoside-triphosphatase [KO:K18532] [EC:2.7.4.3]
YER170W  ADK2; adenylate kinase ADK2 [KO:K00944] [EC:2.7.4.10]
YDR305C  HNT2; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
YDR530C  APA2; bifunctional AP-4-A phosphorylase/ADP sulfurylase [KO:K00988] [EC:2.7.7.5 2.7.7.53]
YCL050C  APA1; bifunctional AP-4-A phosphorylase/ADP sulfurylase [KO:K00988] [EC:2.7.7.5 2.7.7.53]
YKL001C  MET14; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
YJR010W  MET3; sulfate adenylyltransferase [KO:K00958] [EC:2.7.7.4]
YIR027C  DAL1; allantoinase [KO:K01466] [EC:3.5.2.5]
YIR029W  DAL2; allantoicase [KO:K01477] [EC:3.5.3.4]
YIR032C  DAL3; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
sce00030  Pentose phosphate pathway
sce00220  Arginine biosynthesis
sce00250  Alanine, aspartate and glutamate metabolism
sce00260  Glycine, serine and threonine metabolism
sce00340  Histidine metabolism
sce00630  Glyoxylate and dicarboxylate metabolism
sce00730  Thiamine metabolism
sce00740  Riboflavin metabolism
sce00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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