KEGG PATHWAY: sce00564

PATHWAY: sce00564

Entry

sce00564                    Pathway

Name

Glycerophospholipid metabolism - Saccharomyces cerevisiae (budding yeast)

Class

Metabolism; Lipid metabolism

Pathway map

sce00564

Glycerophospholipid metabolism

Module

sce_M00090

Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:sce00564]

sce_M00091

Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:sce00564]

sce_M00092

Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:sce00564]

sce_M00093

Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:sce00564]

Other DBs

GO:

0006650

Organism

Saccharomyces cerevisiae (budding yeast) [GN:sce]

Gene

YOL059W

GPD2; glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [KO:K00006] [EC:1.1.1.8]

YDL022W

GPD1; glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 [KO:K00006] [EC:1.1.1.8]

YIL155C

GUT2; glycerol-3-phosphate dehydrogenase [KO:K00111] [EC:1.1.5.3]

YKR067W

GPT2; bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 [KO:K13507] [EC:2.3.1.15 2.3.1.42]

YBL011W

SCT1; bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [KO:K13507] [EC:2.3.1.15 2.3.1.42]

YDL052C

SLC1; 1-acylglycerol-3-phosphate O-acyltransferase SLC1 [KO:K13509] [EC:2.3.1.51]

YOR175C

ALE1; lysophospholipid acyltransferase [KO:K13519] [EC:2.3.1.51 2.3.1.23 2.3.1.-]

YKR089C

TGL4; triacylglycerol lipase [KO:K14674] [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]

YOR081C

TGL5; triacylglycerol lipase [KO:K14674] [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]

YPR139C

LOA1; lysophosphatidic acid acyltransferase LOA1 [KO:K22831] [EC:2.3.1.51]

YIL124W

AYR1; acylglycerone-phosphate reductase [KO:K06123] [EC:1.1.1.101]

YMR165C

PAH1; phosphatidate phosphatase PAH1 [KO:K15728] [EC:3.1.3.4]

YDR284C

DPP1; bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase [KO:K18693] [EC:3.6.1.75 3.1.3.4]

YDR503C

LPP1; phosphatidate phosphatase LPP1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]

YOR311C

DGK1; diacylglycerol kinase [KO:K16368] [EC:2.7.1.174]

YNL130C

CPT1; diacylglycerol cholinephosphotransferase [KO:K00994] [EC:2.7.8.2]

YPL206C

PGC1; phosphatidylglycerol phospholipase [KO:K18694] [EC:3.1.4.-]

YKR031C

SPO14; phospholipase D [KO:K01115] [EC:3.1.4.4]

YMR006C

PLB2; lysophospholipase [KO:K13333] [EC:3.1.1.5]

YOL011W

PLB3; lysophospholipase [KO:K13333] [EC:3.1.1.5]

YMR008C

PLB1; lysophospholipase [KO:K13333] [EC:3.1.1.5]

YML059C

NTE1; lysophospholipase [KO:K14676] [EC:3.1.1.5]

YPL110C

GDE1; glycerophosphocholine phosphodiesterase [KO:K18696] [EC:3.1.4.46]

YLR133W

CKI1; bifunctional choline kinase/ethanolamine kinase CKI1 [KO:K00866] [EC:2.7.1.32]

YGR202C

PCT1; choline-phosphate cytidylyltransferase [KO:K00968] [EC:2.7.7.15]

YHR123W

EPT1; bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase [KO:K00993] [EC:2.7.8.1]

YDR147W

EKI1; bifunctional choline kinase/ethanolamine kinase EKI1 [KO:K00894] [EC:2.7.1.82]

YGR007W

ECT1; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]

YJR073C

OPI3; bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]

YGR157W

CHO2; phosphatidylethanolamine N-methyltransferase [KO:K16369] [EC:2.1.1.17]

YBR029C

CDS1; phosphatidate cytidylyltransferase [KO:K00981] [EC:2.7.7.41]

YER026C

CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

YNL169C

PSD1; phosphatidylserine decarboxylase 1 [KO:K01613] [EC:4.1.1.65]

YGR170W

PSD2; phosphatidylserine decarboxylase 2 [KO:K01613] [EC:4.1.1.65]

YCL004W

PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [KO:K00995] [EC:2.7.8.5]

YHR100C

GEP4; phosphatidylglycerophosphatase [KO:K01094] [EC:3.1.3.27]

YDL142C

CRD1; cardiolipin synthase [KO:K08744] [EC:2.7.8.41]

YPR140W

TAZ1; lysophosphatidylcholine acyltransferase [KO:K13511] [EC:2.3.1.-]

YGR110W

CLD1; carboxylic ester hydrolase [KO:K13535] [EC:3.1.1.-]

YPR113W

PIS1; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]

Compound

C00040

Acyl-CoA

C00065

L-Serine

C00084

Acetaldehyde

C00093

sn-Glycerol 3-phosphate

C00111

Glycerone phosphate

C00114

Choline

C00157

Phosphatidylcholine

C00189

Ethanolamine

C00269

CDP-diacylglycerol

C00307

CDP-choline

C00344

Phosphatidylglycerol

C00346

Ethanolamine phosphate

C00350

Phosphatidylethanolamine

C00416

Phosphatidate

C00513

CDP-glycerol

C00570

CDP-ethanolamine

C00588

Choline phosphate

C00623

sn-Glycerol 1-phosphate

C00641

1,2-Diacyl-sn-glycerol

C00670

sn-Glycero-3-phosphocholine

C00681

1-Acyl-sn-glycerol 3-phosphate

C01194

1-Phosphatidyl-D-myo-inositol

C01210

N-Methylethanolamine phosphate

C01233

sn-Glycero-3-phosphoethanolamine

C01241

Phosphatidyl-N-methylethanolamine

C01996

Acetylcholine

C02737

Phosphatidylserine

C03372

Acylglycerone phosphate

C03819

1-Acylglycerophosphoinositol

C03872

L-Serine-phosphoethanolamine

C03892

Phosphatidylglycerophosphate

C03974

2-Acyl-sn-glycerol 3-phosphate

C04230

1-Acyl-sn-glycero-3-phosphocholine

C04233

2-Acyl-sn-glycero-3-phosphocholine

C04308

Phosphatidyl-N-dimethylethanolamine

C04438

1-Acyl-sn-glycero-3-phosphoethanolamine

C04590

3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate

C04638

2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate

C05973

2-Acyl-sn-glycero-3-phosphoethanolamine

C05974

2-Acyl-sn-glycero-3-phosphoserine

C05976

Aminoacyl-phosphatidylglycerol

C05980

Cardiolipin

C06771

Triethanolamine

C06772

Diethanolamine

C13482

Phosphodimethylethanolamine

C18059

CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol

C18125

1-Acyl-sn-glycero-3-phosphoserine

C18126

1-Acyl-sn-glycero-3-phosphoglycerol

C18129

Monolysocardiolipin

C18168

Diacylglycerylhomoserine

C18169

Diacylglyceryl-N,N,N-trimethylhomoserine

C20466

2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine

C20518

2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate

C22340

Heptaprenylglyceryl phosphate

C22341

Heptaprenylglycerol

C22342

Diacetylheptaprenylglycerol

Reference

PMID:1512203

Authors

Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.

Title

The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.

Journal

J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992

Reference

PMID:10092508

Authors

Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.

Title

Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.

Journal

Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411

Reference

PMID:10542045

Authors

Athenstaedt K, Daum G.

Title

Phosphatidic acid, a key intermediate in lipid metabolism.

Journal

Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x

Reference

PMID:12431977

Authors

Shields DJ, Lehner R, Agellon LB, Vance DE.

Title

Membrane topography of human phosphatidylethanolamine N-methyltransferase.

Journal

J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200

Reference

PMID:14663079

Authors

Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.

Title

Pathways for phosphatidylcholine biosynthesis in bacteria.

Journal

Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0

Reference

PMID:15522832

Authors

Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.

Title

Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.

Journal

Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007

Reference

PMID:1649829

Authors

Hsu L, Jackowski S, Rock CO

Title

Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.

Journal

J Biol Chem 266:13783-8 (1991)

Reference

PMID:10938271

Authors

Stone SJ, Vance JE.

Title

Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.

Journal

J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200

Related
pathway

sce00010