KEGG   PATHWAY: sce00260
Entry
sce00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Saccharomyces cerevisiae (budding yeast)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sce00260  Glycine, serine and threonine metabolism
sce00260

Module
sce_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sce00260]
sce_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sce00260]
sce_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sce00260]
sce_M00621  Glycine cleavage system [PATH:sce00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YER052C  HOM3; aspartate kinase [KO:K00928] [EC:2.7.2.4]
YDR158W  HOM2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
YJR139C  HOM6; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
YHR025W  THR1; homoserine kinase [KO:K00872] [EC:2.7.1.39]
YCR053W  THR4; threonine synthase THR4 [KO:K01733] [EC:4.2.3.1]
YEL046C  GLY1; threonine aldolase GLY1 [KO:K01620] [EC:4.1.2.48]
YBR263W  SHM1; glycine hydroxymethyltransferase SHM1 [KO:K00600] [EC:2.1.2.1]
YLR058C  SHM2; glycine hydroxymethyltransferase SHM2 [KO:K00600] [EC:2.1.2.1]
YFL030W  AGX1; alanine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
YDL021W  GPM2; phosphoglycerate mutase family protein GPM2 [KO:K01834] [EC:5.4.2.11]
YKL152C  GPM1; phosphoglycerate mutase GPM1 [KO:K01834] [EC:5.4.2.11]
YOL056W  GPM3; phosphoglycerate mutase family protein GPM3 [KO:K01834] [EC:5.4.2.11]
YGR205W  TDA10; putative ATP-dependent kinase [KO:K15918] [EC:2.7.1.31]
YER081W  SER3; phosphoglycerate dehydrogenase SER3 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YIL074C  SER33; phosphoglycerate dehydrogenase SER33 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
YOR184W  SER1; O-phospho-L-serine:2-oxoglutarate transaminase [KO:K00831] [EC:2.6.1.52]
YGR208W  SER2; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
YMR226C  ORA1; oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
YDR232W  HEM1; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
YMR189W  GCV2; glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
YDR019C  GCV1; glycine decarboxylase subunit T [KO:K00605] [EC:2.1.2.10]
YFL018C  LPD1; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
YAL044C  GCV3; glycine decarboxylase subunit H [KO:K02437]
YER026C  CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
YGR155W  CYS4; cystathionine beta-synthase CYS4 [KO:K01697] [EC:4.2.1.22]
YAL012W  CYS3; cystathionine gamma-lyase CYS3 [KO:K01758] [EC:4.4.1.1]
YER086W  ILV1; threonine ammonia-lyase ILV1 [KO:K01754] [EC:4.3.1.19]
YCL064C  CHA1; L-serine/L-threonine ammonia-lyase CHA1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
YGL196W  DSD1; D-serine ammonia-lyase DSD1 [KO:K20498] [EC:4.3.1.18]
YGL026C  TRP5; tryptophan synthase TRP5 [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sce00010  Glycolysis / Gluconeogenesis
sce00020  Citrate cycle (TCA cycle)
sce00230  Purine metabolism
sce00250  Alanine, aspartate and glutamate metabolism
sce00270  Cysteine and methionine metabolism
sce00290  Valine, leucine and isoleucine biosynthesis
sce00300  Lysine biosynthesis
sce00330  Arginine and proline metabolism
sce00460  Cyanoamino acid metabolism
sce00470  D-Amino acid metabolism
sce00564  Glycerophospholipid metabolism
sce00600  Sphingolipid metabolism
sce00620  Pyruvate metabolism
sce00630  Glyoxylate and dicarboxylate metabolism
sce00640  Propanoate metabolism
sce00680  Methane metabolism
sce00860  Porphyrin metabolism
sce00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system