KEGG   PATHWAY: sce04148
Entry
sce04148                    Pathway                                
Name
Efferocytosis - Saccharomyces cerevisiae (budding yeast)
Class
Cellular Processes; Transport and catabolism
Pathway map
sce04148  Efferocytosis
sce04148

Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YAL002W  VPS8; CORVET complex membrane-binding subunit VPS8 [KO:K20178]
YAL026C  DRS2; aminophospholipid-translocating P4-type ATPase DRS2 [KO:K14802] [EC:7.6.2.1]
YBL016W  FUS3; mitogen-activated serine/threonine-protein kinase FUS3 [KO:K04371] [EC:2.7.11.24]
YBR147W  RTC2; cationic amino acid transporter [KO:K23678]
YBR276C  PPS1; tyrosine/serine/threonine protein phosphatase PPS1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
YCR094W  CDC50; aminophospholipid translocase regulatory protein CDC50 [KO:K26935]
YDL077C  VAM6; Vam6p [KO:K20183]
YDR080W  VPS41; Vps41p [KO:K20184]
YDR352W  YPQ2; Ypq2p [KO:K23678]
YDR495C  VPS3; CORVET complex subunit VPS3 [KO:K20177]
YEL024W  RIP1; ubiquinol--cytochrome-c reductase catalytic subunit RIP1 [KO:K00411] [EC:7.1.1.8]
YGR040W  KSS1; mitogen-activated serine/threonine-protein kinase KSS1 [KO:K04371] [EC:2.7.11.24]
YKL140W  TGL1; sterol esterase [KO:K01052] [EC:3.1.1.13]
YKL184W  SPE1; ornithine decarboxylase SPE1 [KO:K01581] [EC:4.1.1.17]
YKR014C  YPT52; Rab family GTPase YPT52 [KO:K07888]
YLR113W  HOG1; mitogen-activated protein kinase HOG1 [KO:K04441] [EC:2.7.11.24]
YLR148W  PEP3; tethering complex subunit PEP3 [KO:K20181]
YLR260W  LCB5; sphinganine kinase LCB5 [KO:K04718] [EC:2.7.1.91]
YLR396C  VPS33; tethering complex ATP-binding subunit VPS33 [KO:K20182]
YML001W  YPT7; Rab family GTPase YPT7 [KO:K07897]
YMR231W  PEP5; tethering complex subunit PEP5 [KO:K20179]
YNL323W  LEM3; Lem3p [KO:K26935]
YOL092W  YPQ1; cationic amino acid transporter [KO:K23678]
YOR171C  LCB4; sphinganine kinase LCB4 [KO:K04718] [EC:2.7.1.91]
YPL045W  VPS16; tethering complex subunit VPS16 [KO:K20180]
YPL111W  CAR1; arginase [KO:K01476] [EC:3.5.3.1]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
sce00010  Glycolysis / Gluconeogenesis
sce04145  Phagocytosis
KO pathway
ko04148   

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