KEGG   PATHWAY: scy00260
Entry
scy00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
scy00260  Glycine, serine and threonine metabolism
scy00260

Module
scy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:scy00260]
scy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:scy00260]
scy_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:scy00260]
scy_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:scy00260]
scy_M00621  Glycine cleavage system [PATH:scy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488 [GN:scy]
Gene
SCATT_29350  aspartate kinase [KO:K00928] [EC:2.7.2.4]
SCATT_p03490  Aspartate kinase [KO:K00928] [EC:2.7.2.4]
SCATT_25010  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SCATT_29340  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SCATT_p03510  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SCATT_41630  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SCATT_41650  homoserine kinase [KO:K00872] [EC:2.7.1.39]
SCATT_p08600  threonine synthase-like protein [KO:K01733] [EC:4.2.3.1]
SCATT_41640  threonine synthase [KO:K01733] [EC:4.2.3.1]
SCATT_24340  threonine synthase [KO:K01733] [EC:4.2.3.1]
SCATT_08210  putative aldolase [KO:K01620] [EC:4.1.2.48]
SCATT_41740  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SCATT_37390  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SCATT_42870  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SCATT_48470  transferase [KO:K00865] [EC:2.7.1.165]
SCATT_24830  putative phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SCATT_43270  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SCATT_23870  putative phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SCATT_10010  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
SCATT_31630  hypothetical protein [KO:K01079] [EC:3.1.3.3]
SCATT_p06200  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SCATT_p06210  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SCATT_p06130  amine oxidase [KO:K00274] [EC:1.4.3.4]
SCATT_p08470  L-amino-acid oxidase [KO:K00274] [EC:1.4.3.4]
SCATT_50430  tyramine oxidase [KO:K00276] [EC:1.4.3.21]
SCATT_07130  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SCATT_42890  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
SCATT_13010  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SCATT_01230  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SCATT_42880  glycine cleavage system H protein [KO:K02437]
SCATT_28970  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
SCATT_41430  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
SCATT_p14710  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
SCATT_48480  putative phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SCATT_37070  putative betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCATT_44570  Aldehyde Dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCATT_44620  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCATT_20800  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SCATT_31680  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
SCATT_42860  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SCATT_38290  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SCATT_11540  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SCATT_11550  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
SCATT_10600  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
SCATT_45590  class III aminotransferase [KO:K00836] [EC:2.6.1.76]
SCATT_10590  putative L-2,4-diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
SCATT_10610  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
SCATT_10620  putative ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
SCATT_11410  amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
SCATT_p05030  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
scy00010  Glycolysis / Gluconeogenesis
scy00020  Citrate cycle (TCA cycle)
scy00230  Purine metabolism
scy00250  Alanine, aspartate and glutamate metabolism
scy00270  Cysteine and methionine metabolism
scy00290  Valine, leucine and isoleucine biosynthesis
scy00300  Lysine biosynthesis
scy00330  Arginine and proline metabolism
scy00460  Cyanoamino acid metabolism
scy00470  D-Amino acid metabolism
scy00564  Glycerophospholipid metabolism
scy00600  Sphingolipid metabolism
scy00620  Pyruvate metabolism
scy00630  Glyoxylate and dicarboxylate metabolism
scy00640  Propanoate metabolism
scy00680  Methane metabolism
scy00860  Porphyrin metabolism
scy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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