KEGG   PATHWAY: senn00260
Entry
senn00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Newport USMARC-S3124.1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
senn00260  Glycine, serine and threonine metabolism
senn00260

Module
senn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:senn00260]
senn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:senn00260]
senn_M00621  Glycine cleavage system [PATH:senn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Newport USMARC-S3124.1 [GN:senn]
Gene
SN31241_5370  Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
SN31241_9770  Bifunctional aspartokinase/homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
SN31241_45850  Bifunctional aspartokinase/homoserine dehydrogenase 2 [KO:K12525] [EC:2.7.2.4 1.1.1.3]
SN31241_3540  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SN31241_9780  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
SN31241_9790  Threonine synthase [KO:K01733] [EC:4.2.3.1]
SN31241_19520  L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SN31241_36640  Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
SN31241_22020  reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SN31241_2370  reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SN31241_15300  Glycerate kinase 1 [KO:K00865] [EC:2.7.1.165]
SN31241_35970  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
SN31241_43760  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
SN31241_40690  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
SN31241_17710  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SN31241_9620  phosphoglycerate mutase gpmB [KO:K15634] [EC:5.4.2.11]
SN31241_1760  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SN31241_41760  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SN31241_19900  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SN31241_9550  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SN31241_25830  NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SN31241_1710  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SN31241_1720  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SN31241_41670  Glycine dehydrogenase [decarboxylating] 1 [KO:K00281] [EC:1.4.4.2]
SN31241_41690  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SN31241_11400  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SN31241_41680  Glycine cleavage system H protein [KO:K02437]
SN31241_37680  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
SN31241_43700  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
SN31241_29120  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
SN31241_40810  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
SN31241_33080  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SN31241_43740  Threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
SN31241_48150  Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
SN31241_750  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
SN31241_41280  protein YgeA [KO:K25316] [EC:5.1.1.10]
SN31241_28100  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
SN31241_28090  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
senn00010  Glycolysis / Gluconeogenesis
senn00020  Citrate cycle (TCA cycle)
senn00230  Purine metabolism
senn00250  Alanine, aspartate and glutamate metabolism
senn00270  Cysteine and methionine metabolism
senn00290  Valine, leucine and isoleucine biosynthesis
senn00300  Lysine biosynthesis
senn00330  Arginine and proline metabolism
senn00460  Cyanoamino acid metabolism
senn00470  D-Amino acid metabolism
senn00564  Glycerophospholipid metabolism
senn00600  Sphingolipid metabolism
senn00620  Pyruvate metabolism
senn00630  Glyoxylate and dicarboxylate metabolism
senn00640  Propanoate metabolism
senn00680  Methane metabolism
senn00860  Porphyrin metabolism
senn00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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