KEGG   PATHWAY: seno00260
Entry
seno00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Enteritidis EC20090193
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
seno00260  Glycine, serine and threonine metabolism
seno00260

Module
seno_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:seno00260]
seno_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:seno00260]
seno_M00621  Glycine cleavage system [PATH:seno00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Enteritidis EC20090193 [GN:seno]
Gene
AU37_20645  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
AU37_22500  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
AU37_20125  metL; bifunctional aspartokinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
AU37_17350  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AU37_22505  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AU37_00010  threonine synthase [KO:K01733] [EC:4.2.3.1]
AU37_04355  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AU37_20155  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AU37_12855  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AU37_09895  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AU37_17905  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AU37_12545  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AU37_14250  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AU37_15920  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AU37_02575  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AU37_03720  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
AU37_22425  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AU37_18200  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AU37_14775  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AU37_04560  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
AU37_22390  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AU37_07955  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AU37_18225  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AU37_18220  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AU37_14730  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
AU37_14740  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AU37_00780  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AU37_14735  glycine cleavage system protein H [KO:K02437]
AU37_13070  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
AU37_14305  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AU37_15890  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AU37_11075  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AU37_06220  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AU37_15910  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AU37_19150  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AU37_18665  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
AU37_14530  racemase [KO:K25316] [EC:5.1.1.10]
AU37_06720  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AU37_06725  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
seno00010  Glycolysis / Gluconeogenesis
seno00020  Citrate cycle (TCA cycle)
seno00230  Purine metabolism
seno00250  Alanine, aspartate and glutamate metabolism
seno00270  Cysteine and methionine metabolism
seno00290  Valine, leucine and isoleucine biosynthesis
seno00300  Lysine biosynthesis
seno00330  Arginine and proline metabolism
seno00460  Cyanoamino acid metabolism
seno00470  D-Amino acid metabolism
seno00564  Glycerophospholipid metabolism
seno00600  Sphingolipid metabolism
seno00620  Pyruvate metabolism
seno00630  Glyoxylate and dicarboxylate metabolism
seno00640  Propanoate metabolism
seno00680  Methane metabolism
seno00860  Porphyrin metabolism
seno00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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