KEGG   PATHWAY: sgla00260
Entry
sgla00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Shewanella glacialimarina
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sgla00260  Glycine, serine and threonine metabolism
sgla00260

Module
sgla_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sgla00260]
sgla_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sgla00260]
sgla_M00555  Betaine biosynthesis, choline => betaine [PATH:sgla00260]
sgla_M00621  Glycine cleavage system [PATH:sgla00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Shewanella glacialimarina [GN:sgla]
Gene
FJ709_16640  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
FJ709_04935  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
FJ709_02415  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
FJ709_06180  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FJ709_04940  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
FJ709_04945  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
FJ709_12640  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
FJ709_14155  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FJ709_17545  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FJ709_04545  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
FJ709_19250  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
FJ709_16910  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FJ709_09845  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
FJ709_04820  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
FJ709_18935  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
FJ709_18940  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
FJ709_03225  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
FJ709_03215  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
FJ709_01510  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FJ709_03220  gcvH; glycine cleavage system protein GcvH [KO:K02437]
FJ709_09770  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
FJ709_08970  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
FJ709_08975  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
FJ709_08420  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
FJ709_17550  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
FJ709_15065  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
FJ709_12170  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
FJ709_12165  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sgla00010  Glycolysis / Gluconeogenesis
sgla00020  Citrate cycle (TCA cycle)
sgla00230  Purine metabolism
sgla00250  Alanine, aspartate and glutamate metabolism
sgla00270  Cysteine and methionine metabolism
sgla00290  Valine, leucine and isoleucine biosynthesis
sgla00300  Lysine biosynthesis
sgla00330  Arginine and proline metabolism
sgla00460  Cyanoamino acid metabolism
sgla00470  D-Amino acid metabolism
sgla00564  Glycerophospholipid metabolism
sgla00600  Sphingolipid metabolism
sgla00620  Pyruvate metabolism
sgla00630  Glyoxylate and dicarboxylate metabolism
sgla00640  Propanoate metabolism
sgla00680  Methane metabolism
sgla00860  Porphyrin metabolism
sgla00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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